WFRF:(Lund Paulsen M.)
Sökning: WFRF:(Lund Paulsen M.) > Effects of germ lin...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03485naa a2200649 4500 | |
| 001 | oai:gup.ub.gu.se/298094 | |
| 003 | SwePub | |
| 008 | 240528s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2980942 URI |
| 024 | 7 | a https://doi.org/10.1182/blood.20200050642 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Tulstrup, M.4 aut |
| 245 | 1 0 | a Effects of germ line DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia |
| 264 | 1 | b American Society of Hematology,c 2020 |
| 520 | a Methotrexate (MTX) during maintenance therapy is essential for curing acute lymphoblastic leukemia (ALL), but dosing strategies aiming at adequate treatment intensity are challenged by interindividual differences in drug disposition. To evaluate genetic factors associated with MTX metabolism, we performed a genome-wide association study in 447 ALL cases from the Nordic Society for Pediatric Haematology and Oncology ALL2008 study, validating results in an independent set of 196 patients. The intergenic single-nucleotide polymorphism rs1382539, located in a regulatory element of DHFR, was associated with increased levels of short-chain MTX polyglutamates (P = 1.1 x 10(-8)) related to suppression of enhancer activity, whereas rs35789560 in FPGS (p.R466C, P = 5.6 x 10(-9)) was associated with decreased levels of long-chain MTX polyglutamates through reduced catalytic activity. Furthermore, the FPGS variant was linked with increased relapse risk (P = .044). These findings show a genetic basis for interpatient variability in MTX response and could be used to improve future dosing algorithms. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a acute lymphoblastic-leukemia | |
| 653 | a high-dose methotrexate | |
| 653 | a maintenance | |
| 653 | a therapy | |
| 653 | a nudt15 polymorphisms | |
| 653 | a nopho all2008 | |
| 653 | a free survival | |
| 653 | a chemotherapy | |
| 653 | a children | |
| 653 | a cell | |
| 653 | a polyglutamates | |
| 653 | a Hematology | |
| 700 | 1 | a Moriyama, T.4 aut |
| 700 | 1 | a Jiang, C.4 aut |
| 700 | 1 | a Grosjean, M.4 aut |
| 700 | 1 | a Nersting, J.4 aut |
| 700 | 1 | a Abrahamsson, Jonas,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences4 aut0 (Swepub:gu)xabrjo |
| 700 | 1 | a Grell, K.4 aut |
| 700 | 1 | a Hjalgrim, L. L.4 aut |
| 700 | 1 | a Jonsson, O. G.4 aut |
| 700 | 1 | a Kanerva, J.4 aut |
| 700 | 1 | a Lund, B.4 aut |
| 700 | 1 | a Nielsen, S. N.4 aut |
| 700 | 1 | a Nielsen, R. L.4 aut |
| 700 | 1 | a Quist-Paulsen, P.4 aut |
| 700 | 1 | a Pruunsild, K.4 aut |
| 700 | 1 | a Wolthers, B. O.4 aut |
| 700 | 1 | a Zhang, H.4 aut |
| 700 | 1 | a Gupta, R.4 aut |
| 700 | 1 | a Yang, J. J.4 aut |
| 700 | 1 | a Schmiegelow, K.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper4 org |
| 773 | 0 | t Bloodd : American Society of Hematologyg 136:10, s. 1161-1168q 136:10<1161-1168x 0006-4971x 1528-0020 |
| 856 | 4 | u https://ashpublications.org/blood/article-pdf/136/10/1161/1756605/bloodbld2020005064.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/298094 |
| 856 | 4 8 | u https://doi.org/10.1182/blood.2020005064 |
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- Moriyama, T.
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- Grosjean, M.
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- Grell, K.
- Hjalgrim, L. L.
- Jonsson, O. G.
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- Nielsen, S. N.
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- Quist-Paulsen, P ...
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