A Developmental Perspective on Paragangliar Tumorigenesis

Lotti, LV (author)

Vespa, S (author)

Perconti, S (author)

Esposito, DL (author)

Visone, R (author)

Veronese, A (author)

Paties, CT (author)

Sanna, M (author)

Verginelli, F (author)

Mariani-Costantini, R (author)

(creator_code:org_t)

Related links:: https://www.mdpi.com...; show more...; http://kipublication...; https://doi.org/10.3...; show less...

Abstract Subject headings

In this review, we propose that paraganglioma is a fundamentally organized, albeit aberrant, tissue composed of neoplastic vascular and neural cell types that share a common origin from a multipotent mesenchymal-like stem/progenitor cell. This view is consistent with the pseudohypoxic footprint implicated in the molecular pathogenesis of the disease, is in harmony with the neural crest origin of the paraganglia, and is strongly supported by the physiological model of carotid body hyperplasia. Our immunomorphological and molecular studies of head and neck paragangliomas demonstrate in all cases relationships between the vascular and the neural tumor compartments, that share mesenchymal and immature vasculo-neural markers, conserved in derived cell cultures. This immature, multipotent phenotype is supported by constitutive amplification of NOTCH signaling genes and by loss of the microRNA-200s and -34s, which control NOTCH1, ZEB1, and PDGFRA in head and neck paraganglioma cells. Importantly, the neuroepithelial component is distinguished by extreme mitochondrial alterations, associated with collapse of the ΔΨm. Finally, our xenograft models of head and neck paraganglioma demonstrate that mesenchymal-like cells first give rise to a vasculo-angiogenic network, and then self-organize into neuroepithelial-like clusters, a process inhibited by treatment with imatinib.

By the author/editor: Lotti, LV; Vespa, S; Pantalone, MR; Perconti, S; Esposito, DL; Visone, R; show more...; Veronese, A; Paties, CT; Sanna, M; Verginelli, F; Naucler, CS; Mariani-Costanti ...; show less...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.