SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Neerincx M)
 

Search: WFRF:(Neerincx M) > A System Pharmacolo...

  • Abdel-Aziz, MI (author)

A System Pharmacology Multi-Omics Approach toward Uncontrolled Pediatric Asthma

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-05-28
  • MDPI AG,2021

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:146979728
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146979728URI
  • https://doi.org/10.3390/jpm11060484DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • There is a clinical need to identify children with poor asthma control as early as possible, to optimize treatment and/or to find therapeutic alternatives. Here, we present the “Systems Pharmacology Approach to Uncontrolled Pediatric Asthma” (SysPharmPediA) study, which aims to establish a pediatric cohort of moderate-to-severe uncontrolled and controlled patients with asthma, to investigate pathophysiological mechanisms underlying uncontrolled moderate-to-severe asthma in children on maintenance treatment, using a multi-omics systems medicine approach. In this multicenter observational case–control study, moderate-to-severe asthmatic children (age; 6–17 years) were included from four European countries (Netherlands, Germany, Spain, and Slovenia). Subjects were classified based on asthma control and number of exacerbations. Demographics, current and past patient/family history, and clinical characteristics were collected. In addition, systems-wide omics layers, including epi(genomics), transcriptomics, microbiome, proteomics, and metabolomics were evaluated from multiple samples. In all, 145 children were included in this cohort, 91 with uncontrolled (median age = 12 years, 43% females) and 54 with controlled asthma (median age = 11.7 years, 37% females). The two groups did not show statistically significant differences in age, sex, and body mass index z-score distribution. Comprehensive information and diverse noninvasive biosampling procedures for various omics analyses will provide the opportunity to delineate underlying pathophysiological mechanisms of moderate-to-severe uncontrolled pediatric asthma. This eventually might reveal novel biomarkers, which could potentially be used for noninvasive personalized diagnostics and/or treatment.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Neerincx, AH (author)
  • Vijverberg, SJH (author)
  • Hashimoto, S (author)
  • Brinkman, P (author)
  • Gorenjak, M (author)
  • Toncheva, AA (author)
  • Harner, S (author)
  • Brandstetter, S (author)
  • Wolff, C (author)
  • Perez-Garcia, J (author)
  • Hedman, AMKarolinska Institutet (author)
  • Almqvist, CKarolinska Institutet (author)
  • Corcuera-Elosegui, P (author)
  • Korta-Murua, J (author)
  • Sardon-Prado, O (author)
  • Pino-Yanes, M (author)
  • Potocnik, U (author)
  • Kabesch, M (author)
  • Kraneveld, AD (author)
  • van der Zee, AMH (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Journal of personalized medicine: MDPI AG11:62075-4426

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view