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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008856naa a2200877 4500
001oai:DiVA.org:uu-435488
003SwePub
008210226s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4354882 URI
0247 a https://doi.org/10.1530/EJE-20-08002 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Crona, Joakimu Uppsala universitet,Endokrin tumörbiologi4 aut0 (Swepub:uu)joacr310
2451 0a ENSAT registry-based randomized clinical trials for adrenocortical carcinoma
264 1b Bioscientifica,c 2021
338 a print2 rdacarrier
520 a Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been introduced in clinical research, so allowing for significant cost reduction, but without compromising scientific benefit. Herein, we describe how the European Network for the Study of Adrenal Tumours (ENSAT) could transform its current registry into one fit for a clinical trial infrastructure. The rationale to perform randomized registry-based trials in ACC is outlined including an analysis of relevant limitations and challenges. We summarize a survey on this concept among ENSAT members who expressed a strong interest in the concept and rated its scientific potential as high. Legal aspects, including ethical approval of registry-based randomization were identified as potential obstacles. Finally, we describe three potential randomized registry-based clinical trials in an adjuvant setting and for advanced disease with a high potential to be executed within the framework of an advanced ENSAT registry. Thus we, therefore, provide the basis for future registry-based trials for ACC patients. This could ultimately provide proof-of-principle of how to perform more effective randomized trials for an orphan disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Baudin, Ericu Univ Paris Saclay, Dept Imagerie, Serv Oncol Endocrinienne, Gustave Roussy, Villejuif, France.4 aut
7001 a Terzolo, Massimou Univ Turin, Dept Clin & Biol Sci, San Luigi Hosp, Orbassano, Italy.4 aut
7001 a Chrisoulidou, Alexandrau Theagenio Canc Hosp, Dept Endocrinol, Thessaloniki, Greece.4 aut
7001 a Angelousi, Annau Natl & Kapodistrian Univ Athens, Laiko Hosp, Dept Internal Med 1, Unit Endocrinol, Athens, Greece.4 aut
7001 a Ronchi, Cristina L.u Univ Birmingham, Inst Metab & Syst Res, Birmingham, W Midlands, England.;Univ Hosp Wurzburg, Div Endocrinol & Diabet, Wurzburg, Germany.4 aut
7001 a Oliveira, Cristina Lamasu Complejo Hosp Univ Albacete, Endocrinol Dept, Albacete, Spain.4 aut
7001 a van Dijkum, Els J. M. Nieveenu Univ Amsterdam, Canc Ctr Amsterdam, Dept Surg, Amsterdam UMC, Amsterdam, Netherlands.4 aut
7001 a Ceccato, Filippou Univ Hosp Padova, Dept Med DIMED, Endocrinol Unit, Padua, Italy.4 aut
7001 a Borson-Chazot, Francoiseu Univ Claude Bernard Lyon 1, Hosp Civils Lyon, Federat Endocrinol, Lyon, France.4 aut
7001 a Reimondo, Giuseppeu Univ Turin, San Luigi Gonzaga Hosp, Dept Clin & Biol Sci, Internal Med, Turin, Italy.4 aut
7001 a Tiberi, Guido A. M.u Univ Brescia, Dept Clin & Expt Sci, Surg Clin, ASST Spedali Civili, Brescia, Italy.4 aut
7001 a Ettaieb, Hesteru Maxima Med Ctr, Div Endocrinol, Dept Internal Med, Eindhoven, Netherlands.4 aut
7001 a Kiriakopoulos, Andreasu Natl & Kapodistrian Univ Athens, Surg Clin 5, Evgenid Hosp, Sch Med, Athens, Greece.4 aut
7001 a Letizia, Canuu Univ Florence, Dept Expt & Clin Biomed Sci, Florence, Italy.4 aut
7001 a Kastelan, Darkou Univ Hosp Ctr Zagreb, Dept Endocrinol, Zagreb, Croatia.4 aut
7001 a Osher, Esthru Tel Aviv Univ, Tel Aviv Sourasky Med Ctr Israel, Inst Endocrinol Metab & Hypertens, Sackler Fac Med, Tel Aviv, Israel.4 aut
7001 a Yiannakopoulou, Eugeniau Univ West Attica, Dept Biomed Sci, Fac Hlth Sci, Athens, Greece.4 aut
7001 a Arnaldi, Giorgiou Polytech Univ Marche, Dept Clin & Mol Sci, Div Endocrinol, Ancona, Italy.4 aut
7001 a Assie, Guillaumeu Univ Paris, CNRS, Inst Cochin, INSERM, Paris, France.;Hop Cochin, AP HP, Endocrinol, Paris, France.4 aut
7001 a Paiva, Isabelu Ctr Hosp & Univ Coimbra, Dept Endocrinol Diabet & Metab, Coimbra, Portugal.4 aut
7001 a Bourdeau, Isabelleu Ctr Hosp Univ Montreal CHUM, Dept Med, Res Ctr, Div Endocrinol, Montreal, PQ, Canada.4 aut
7001 a Newell-Price, Johnu Univ Sheffield, Dept Oncol & Metab, Med Sch, Sheffield, S Yorkshire, England.4 aut
7001 a Nowak, Karolina M.u Bielanski Hosp, Ctr Postgrad Med Educ, Dept Endocrinol, Warsaw, Poland.4 aut
7001 a Romero, M. Tousu Hosp Univ Virgen Macarena, UGC Endocrinol & Nutr, Seville, Spain.4 aut
7001 a De Martino, Maria Cristinau Univ Federico II Napoli, Dipartimento Med Clin & Chirurg, Sez Endocrinol, Naples, Italy.4 aut
7001 a Bugalho, Maria Joaou CHULN, Serv Endocrinol Diabet & Metabol, Lisbon, Portugal.;Univ Lisbon, Fac Med, Lisbon, Portugal.4 aut
7001 a Sherlock, Marku Beaumont Hosp, Dept Endocrinol, Dublin, Ireland.;Royal Coll Surgeons Ireland, Dublin, Ireland.4 aut
7001 a Vantyghem, Marie-Christineu Lille Univ Hosp, Endocrinol Diabetol Metab & Nutr Dept, Lille, France.4 aut
7001 a Dennedy, Michael Conallu Natl Univ Ireland, Dept Endocrinol & Diabet Mellitus, Dept Med, Clin Sci Inst, Galway, Ireland.4 aut
7001 a Loli, Paulau Osped Niguarda Ca Granda, Endocrinol, Naples, Italy.4 aut
7001 a Rodien, Patriceu CHU Angers, Serv Endocrinol Diabetol & Nutr, Angers 9, France.4 aut
7001 a Feelders, Richardu Erasmus MC, Div Endocrinol, Dept Internal Med, Rotterdam, Netherlands.4 aut
7001 a de Krijger, Ronaldu Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands.;Univ Med Ctr, Dept Pathol, Utrecht, Netherlands.4 aut
7001 a Van Slycke, Samu OLV Hosp Aalst, Gen & Endocrine Surg, Aalst, Belgium.4 aut
7001 a Aylwin, Simonu Kings Coll Hosp London, London, England.4 aut
7001 a Morelli, Valentinau Osped Maggiore Policlin, Endocrinol Unit, Fdn IRCCS Ca Granda, Milan, Italy.4 aut
7001 a Vroonen, Laurentu Ctr Hosp Univ Liege, Dept Endocrinol, Liege, Belgium.4 aut
7001 a Shafigullina, Zulfiyau North Western Med Univ, Endocrinol Dept, St Petersburg, Russia.4 aut
7001 a Bancos, Irinau Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN USA.4 aut
7001 a Trofimiuk-Mueldner, Malgorzatau Jagiellonian Univ Med Coll, Dept Endocrinol, Krakow, Poland.4 aut
7001 a Quinkler, Marcusu Endocrinol Charlottenburg, Berlin, Germany.4 aut
7001 a Luconi, Michaelau Univ Florence, Dept Expt & Clin Biomed Sci, Florence, Italy.4 aut
7001 a Kroiss, Matthiasu Univ Hosp Wurzburg, Div Endocrinol & Diabet, Wurzburg, Germany.;Univ Wurzburg, Comprehens Canc Ctr Mainfranken, Wurzburg, Germany.4 aut
7001 a Naruse, Mitsuhideu Ijinkai Takeda Gen Hosp, Endocrine Ctr, Kyoto, Japan.;NHO Kyoto Med Ctr, Clin Res Inst Endocrinol & Metab, Kyoto, Japan.4 aut
7001 a Igaz, Peteru Semmelweis Univ, Dept Internal Med 2, Budapest, Hungary.;Hungarian Acad Sci, MTA SE Mol Med Res Grp, Budapest, Hungary.;Semmelweis Univ, Budapest, Hungary.4 aut
7001 a Mihai, Raduu Univ Oxford, Dept Endocrine Surg, Churchill Canc Ctr, Oxford, England.4 aut
7001 a Della Casa, Silviau Catholic Univ, Endocrinol Dept, Gemelli Polyclin Fdn, Rome, Italy.4 aut
7001 a Berruti, Alfredou Univ Brescia, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, Med Oncol,ASST Spedali Civili, Brescia, Italy.4 aut
7001 a Fassnacht, Martinu Univ Hosp Wurzburg, Div Endocrinol & Diabet, Wurzburg, Germany.;Univ Wurzburg, Comprehens Canc Ctr Mainfranken, Wurzburg, Germany.4 aut
7001 a Beuschlein, Felixu Univ Spital Zurich, Klin Endokrinol Diabetol & Klin Ernahrung, Zurich, Switzerland.;Klinikum Univ Munchen, Deptr Endocrinol, Med Klin & Poliklin 4, Munich, Germany.4 aut
7102 a Uppsala universitetb Endokrin tumörbiologi4 org
7730 t European Journal of Endocrinologyd : Bioscientificag 184:2, s. R51-R59q 184:2<R51-R59x 0804-4643x 1479-683X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-435488
8564 8u https://doi.org/10.1530/EJE-20-0800

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