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FältnamnIndikatorerMetadata
00009424naa a2201021 4500
001oai:gup.ub.gu.se/271748
003SwePub
008240528s2018 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-145740
009oai:DiVA.org:uu-365986
024a https://gup.ub.gu.se/publication/2717482 URI
024a https://doi.org/10.1093/ije/dyy0312 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1457402 URI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3659862 URI
040 a (SwePub)gud (SwePub)umud (SwePub)uu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Accordini, S.u Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy4 aut
2451 0a A three-generation study on the association of tobacco smoking with asthma
264 c 2018-03-09
264 1b Oxford University Press (OUP),c 2018
520 a Background: Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged <= 51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. Results: Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55). Conclusions: Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a Asthma
653 a mothers' smoking during pregnancy
653 a grandmothers' smoking during pregnancy
653 a fathers'
653 a respiratory-health-survey
653 a maternal nicotine exposure
653 a obstructive
653 a lung-disease
653 a childhood asthma
653 a transgenerational responses
653 a follow-up
653 a pregnancy
653 a cohort
653 a inheritance
653 a expression
653 a asthma
700a Calciano, L.u Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy4 aut
700a Johannessen, A.u Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway4 aut
700a Portas, L.u Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy4 aut
700a Benediktsdottir, B.u Univ Iceland, Fac Med, Reykjavik, Iceland4 aut
700a Jogi, Rainu Uppsala universitet,Lung- allergi- och sömnforskning,Tartu Univ Hosp, Lung Clin, Tartu, Estonia4 aut0 (Swepub:uu)raijo735
700a Bråbäck, Lennartu Umeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, Umea, Sweden4 aut0 (Swepub:umu)lebr0005
700a Carsin, A. E.u Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBER Epidemiol & Salud PUbl CIBERESP, Barcelona, Spain4 aut
700a Dharmage, S. C.u Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy;Univ Melbourne, Sch Populat & Global Hlth, Melbourne, Vic, Australia,Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway4 aut
700a Dratva, J.u ZHAW Sch Hlth Profess, Inst Hlth Sci, Winterthur, Switzerland;Basel Univ, Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland4 aut
700a Forsberg, Bertilu Umeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, Umea, Sweden4 aut0 (Swepub:umu)befo0001
700a Real, F. G.u Univ Bergen, Dept Clin Sci, Bergen, Norway4 aut
700a Heinrich, J.u Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Inner City Clin, Inst & Outpatient Clin Occupat,Social & Environm, Munich, Germany4 aut
700a Holloway, J. W.u Univ Southampton, Fac Med, Human Dev & Hlth, Southampton, Hants, England,Univ Antwerp, Dept Epidemiol & Social Med, Antwerp, Belgium;Univ Antwerp, StatUA Stat Ctr, Antwerp, Belgium4 aut
700a Holm, Mathias,d 1969u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Occupat & Environm Med, Gothenburg, Sweden4 aut0 (Swepub:gu)xhomat
700a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)chrisjn
700a Jogi, R.4 aut
700a Leynaert, B.u INSERM, Pathophysiol & Epidemiol Resp Dis, UMR 1152, Paris, France4 aut
700a Malinovschi, Andrei,d 1978-u Uppsala universitet,Klinisk fysiologi4 aut0 (Swepub:uu)anmal535
700a Marcon, A.u Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy4 aut
700a Rovira, J. M.u CHUA, Hlth Serv Castilla La Mancha SESCAM, Pneumol Serv, Albacete, Spain;Univ Castilla La Mancha, Sch Med, Albacete, Spain4 aut
700a Raherison, C.u Bordeaux Univ, INSERM, U1219, Bordeaux, France4 aut
700a Sanchez-Ramos, J.u Univ Huelva, Dept Nursing, Huelva, Spain4 aut
700a Schlunssen, V.u Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark;Natl Res Ctr Working Environm, Copenhagen, Denmark4 aut
700a Bono, R.u Univ Turin, Dept Publ Hlth & Pediat, Turin, Italy4 aut
700a Corsico, A. G.u Univ Pavia, IRCCS San Matteo Hosp Fdn, Div Resp Dis, Pavia, Italy4 aut
700a Demoly, P.u Univ Montpellier, Hop Arnaud Villeneuve, Dept Pneumol & Addictol, Montpellier, France;Sorbonne Univ, INSERM, IPLESP, Paris, France4 aut
700a Arenas, S.u Galdakao Usansolo Hosp, Pulmonol Dept, Biscay, Spain4 aut
700a Nowak, D.u Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Inner City Clin, Inst & Outpatient Clin Occupat,Social & Environm, Munich, Germany;Comprehens Pneumol Ctr Munich, German Ctr Lung Res, Munich, Germany4 aut
700a Pin, I.u CHU Grenoble Alpes, Pediat, Grenoble, France;Inst Adv Biosci, INSERM 1209, Grenoble, France;Univ Grenoble Alpes, Grenoble, France4 aut
700a Weyler, J.4 aut
700a Jarvis, D.u Imperial Coll, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England;Imperial Coll, MRC PHE Ctr Environm & Hlth, London, England4 aut
700a Svanes, C.4 aut
710a Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italyb Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway4 org
773t International Journal of Epidemiologyd : Oxford University Press (OUP)g 47:4, s. 1106-1117q 47:4<1106-1117x 0300-5771x 1464-3685
856u https://academic.oup.com/ije/article-pdf/47/4/1106/25687458/dyy031.pdf
856u https://doi.org/10.1093/ije/dyy031y Fulltext
856u https://umu.diva-portal.org/smash/get/diva2:1191092/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
856u https://uu.diva-portal.org/smash/get/diva2:1265178/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/271748
8564 8u https://doi.org/10.1093/ije/dyy031
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-145740
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-365986

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