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  • Borg Hammer, Anne SofieDepartment of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (författare)

Hypodiploidy has unfavorable impact on survival in pediatric acute myeloid leukemia : An I-BFM Study Group collaboration

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023-03-20
  • American Society of Hematology,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-207697
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-207697URI
  • https://doi.org/10.1182/bloodadvances.2022008251DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Hypodiploidy, defined as modal numbers (MNs) 45 or lower, has not been independently investigated in pediatric acute myeloid leukemia (AML) but is a well-described high-risk factor in pediatric acute lymphoblastic leukemia. We aimed to characterize and study the prognostic impact of hypodiploidy in pediatric AML. In this retrospective cohort study, we included children below 18 years of age with de novo AML and a hypodiploid karyotype diagnosed from 2000 to 2015 in 14 childhood AML groups from the International Berlin-Frankfurt-Münster (I-BFM) framework. Exclusion criteria comprised constitutional hypodiploidy, monosomy 7, composite karyotype, and t(8;21) with concurring sex chromosome loss. Hypodiploidy occurred in 81 patients (1.3%) with MNs, 45 (n = 66); 44 (n = 10) and 43 (n = 5). The most frequently lost chromosomes were chromosome 9 and sex chromosomes. Five-year event-free survival (EFS) and overall survival (OS) were 34% and 52%, respectively, for the hypodiploid cohort. Children with MN≤44 (n = 15) had inferior EFS (21%) and OS (33%) compared with children with MN = 45 (n = 66; EFS, 37%; OS, 56%). Adjusted hazard ratios (HRs) were 4.9 (P = .001) and 6.1 (P = .003). Monosomal karyotype or monosomy 9 had particular poor OS (43% and 15%, respectively). Allogeneic stem cell transplantation (SCT) in first complete remission (CR1) (n = 18) did not mitigate the unfavorable outcome of hypodiploidy (adjusted HR for OS was 1.5; P = .42). We identified pediatric hypodiploid AML as a rare subgroup with an inferior prognosis even in the patients treated with SCT in CR1.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Løvvik Juul-Dam, KristianDepartment of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (författare)
  • Damgaard Sandahl, JulieDepartment of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (författare)
  • Abrahamsson, JonasChildren's Cancer Center, Queen Silvia's Children's Hospital, Göteborg, Sweden (författare)
  • Czogala, MalgorzataDepartment of Pediatric Oncology and Hematology, Jagiellonian University Medical College, Institute of Pediatrics, Krakow, Poland (författare)
  • Delabesse, EmmanuelleToulouse-Oncopole, Laboratoire d'Hématologie Secteur Génétique des Hémopathies, Toulouse, France (författare)
  • Haltrich, Iren2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary (författare)
  • Jahnukainen, KirsiNew Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland (författare)
  • Kolb, E. AndersNemours/Alfred I. DuPont Hospital for Children, DE, Wilmington, United States (författare)
  • Kovács, Gábor2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary (författare)
  • Leverger, GuyHopital Armand Trousseau, Assistance Publique-Hopitaux de Paris, Service d'Hematologie et d'Oncologie Pediatrique, Paris, France (författare)
  • Locatelli, FrancoDepartment of Pediatric Haematology/Oncology and Cell and Gene Therapy, IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Italy (författare)
  • Masetti, RiccardoDipartimento di Scienze Mediche e Chirurgiche, Pediatric Oncology and Hematology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (författare)
  • Norén-Nyström, UlrikaUmeå universitet,Pediatrik(Swepub:umu)kagr0007 (författare)
  • Raimondi, Susana C.St Jude Children's Research Hospital, TN, Memphis, United States (författare)
  • Rasche, MareikeDepartment of Pediatric Hematology-Oncology, Pediatrics III, University Hospital of Essen, Essen, Germany (författare)
  • Reinhardt, DirkDepartment of Pediatric Hematology-Oncology, Pediatrics III, University Hospital of Essen, Essen, Germany (författare)
  • Taki, TomohikoFaculty of Health Sciences, Laboratory of Clinical Hematology, Department of Medical Technology, Kyorin University, Mitaka, Japan (författare)
  • Tomizawa, DaisukeDivision of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan (författare)
  • Zeller, BernwardDepartment of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway (författare)
  • Hasle, HenrikDepartment of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark (författare)
  • Kjeldsen, EigilDepartment of Hematology, Hemodiagnostic Laboratory, Aarhus University Hospital, Aarhus, Denmark (författare)
  • Department of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus, DenmarkChildren's Cancer Center, Queen Silvia's Children's Hospital, Göteborg, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Blood Advances: American Society of Hematology7:6, s. 1045-10552473-95292473-9537

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