Co-morbidity in patients with early rheumatoid arthritis - inflammation matters

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Rantapää Dahlqvist Solveig) > (2015-2019) > Co-morbidity in pat...

Co-morbidity in patients with early rheumatoid arthritis - inflammation matters

Innala, Lena, 1060- (author): Umeå universitet,Reumatologi

Sjöberg, Clara, 1986- (author): Umeå universitet,Reumatologi

Möller, Bozena (author)

Ljung, Lotta, 1964- (author): Umeå universitet,Reumatologi

Smedby, Torgny (author)

Södergren, Anna, 1977- (author): Umeå universitet,Reumatologi

Magnusson, Staffan (author)

Rantapää-Dahlqvist, Solbritt, 1947- (author): Umeå universitet,Reumatologi

Wållberg-Jonsson, Solveig, 1953- (author): Umeå universitet,Reumatologi

show less...

(creator_code:org_t)

2016-01-28
2016
English.
In: Arthritis Research & Therapy. - : BioMed Central. - 1478-6362. ; 18

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://arthritis-re...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Patients with rheumatoid arthritis (RA) suffer from co-morbidities that contribute to a shortened lifespan. Inflammation is important for the development of cardiovascular disease, but little is known on its relationship with other co-morbidities. We investigated the role of inflammation for the development of new comorbidities in early RA. Methods: Since 1995, all patients with early RA in Northern Sweden are included in a prospective study on comorbidities, with a total of 950 patients being included. At the time for this study, 726 had been ill for >= 5 years. Data on co-morbidities, clinical and laboratory disease activity and pharmacological therapy were collected from patient records and further validated using a questionnaire at RA onset (T0) and after 5 years (T5). Results: Of the patients, 53.2 % of the patients had one or more co-morbidity at onset, the commonest being: hypertension (27.3 %), obstructive pulmonary disease (13.9 %), diabetes (8.0 %), hypothyroidism (6.3 %) and malignancy (5.0 %). After 5 years, 41.0 % had developed at least one new co-morbidity, the most common being: hypertension (15.1 %), malignancy (7.6 %), stroke/transient ischemic accident (5.1 %), myocardial infarction (4.3 %) and osteoporosis (3.7 %). Age at disease onset, a raised erythrocyte sedimentation rate (ESR) at inclusion, previous treatment with glucocorticoids (GC; p < 0.001 for all), extra-articular RA (Ex-RA; p < 0.01), DAS28 (area under the curve) at 24 months (p < 0.05), previous smoking at inclusion (p = 0.058) and male gender (p < 0.01) were associated with a new co-morbidity overall at T5. Treatment with biologics (p < 0.05) reduced the risk. In multiple logistic regression modelling, ESR (p = 0.036) at inclusion was associated with a new co-morbidity after 5 years, adjusted for age, sex, smoking and GC treatment. In a similar model, Ex-RA (p < 0.05) was associated with a new co-morbidity at T5. In a third model, adjusted for age and sex, a new pulmonary co-morbidity was associated with a smoking history at inclusion (p < 0.01), but not with ESR. Conclusion: There was substantial co-morbidity among early RA patients already at disease onset, with considerable new co-morbidity being added during the first five years. Measures of disease activity were associated with the occurrence of a new co-morbidity indicating that the inflammation is of importance in this context.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

Keyword

Early rheumatoid arthritis
Co-morbidity
Inflammation

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Arthritis Research & Therapy (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Innala, Lena, 10 ...; Sjöberg, Clara, ...; Möller, Bozena; Ljung, Lotta, 19 ...; Smedby, Torgny; Södergren, Anna, ...; show more...; Magnusson, Staff ...; Rantapää-Dahlqvi ...; Wållberg-Jonsson ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Rheumatology and ...

Articles in the publication: Arthritis Resear ...

By the university: Umeå University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se