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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04674naa a2200697 4500 | |
| 001 | oai:gup.ub.gu.se/238539 | |
| 003 | SwePub | |
| 008 | 240528s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2385392 URI |
| 024 | 7 | a https://doi.org/10.3233/jad-1509142 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jefferson, A. L.4 aut |
| 245 | 1 0 | a The Vanderbilt Memory & Aging Project: Study Design and Baseline Cohort Overview |
| 264 | 1 | b IOS Press,c 2016 |
| 520 | a Background: Vascular health factors frequently co-occur with Alzheimer's disease (AD). A better understanding of how systemic vascular and cerebrovascular health intersects with clinical and pathological AD may inform prevention and treatment opportunities. Objective: To establish the Vanderbilt Memory & Aging Project, a case-control longitudinal study investigating vascular health and brain aging, and describe baseline methodology and participant characteristics. Methods: From September 2012 to November 2014, 335 participants age 60-92 were enrolled, including 168 individuals with mild cognitive impairment (MCI, 73 +/- 8 years, 41% female) and 167 age-, sex-, and race-matched cognitively normal controls (NC, 72 +/- 7 years, 41% female). At baseline, participants completed a physical and frailty examination, fasting blood draw, neuropsychological assessment, echocardiogram, cardiac MRI, and brain MRI. A subset underwent 24-hour ambulatory blood pressure monitoring and lumbar puncture for cerebrospinal fluid (CSF) collection. Results: As designed, participant groups were comparable for age (p = 0.31), sex (p = 0.95), and race (p = 0.65). MCI participants had greater Framingham Stroke Risk Profile scores (p = 0.008), systolic blood pressure values (p = 0.008), and history of left ventricular hypertrophy (p = 0.04) than NC participants. As expected, MCI participants performed worse on all neuropsychological measures (p-values <0.001), were more likely to be APOE epsilon 4 carriers (p = 0.02), and had enhanced CSF biomarkers, including lower A beta(42) (p = 0.02), higher total tau (p = 0.004), and higher p-tau (p = 0.02) compared to NC participants. Conclusion: Diverse sources of baseline and longitudinal data will provide rich opportunities to investigate pathways linking vascular and cerebrovascular health, clinical and pathological AD, and neurodegeneration contributing to novel strategies to delay or prevent cognitive decline. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a Alzheimer's disease | |
| 653 | a biomarkers | |
| 653 | a brain MRI | |
| 653 | a cardiac MRI | |
| 653 | a mild cognitive impairment | |
| 653 | a vascular risk | |
| 653 | a mild cognitive impairment | |
| 653 | a magnetic-resonance images | |
| 653 | a older-adults | |
| 653 | a alzheimers-disease | |
| 653 | a american-society | |
| 653 | a echocardiographic-assessment | |
| 653 | a doppler-echocardiography | |
| 653 | a cerebrospinal-fluid | |
| 653 | a clinical-practice | |
| 653 | a cerebral-cortex | |
| 653 | a Neurosciences & Neurology | |
| 700 | 1 | a Gifford, K. A.4 aut |
| 700 | 1 | a Acosta, L. M. Y.4 aut |
| 700 | 1 | a Bell, S. P.4 aut |
| 700 | 1 | a Donahue, M. J.4 aut |
| 700 | 1 | a Davis, L. T.4 aut |
| 700 | 1 | a Gottlieb, J.4 aut |
| 700 | 1 | a Gupta, D. K.4 aut |
| 700 | 1 | a Hohman, T. J.4 aut |
| 700 | 1 | a Lane, E. M.4 aut |
| 700 | 1 | a Libon, D. J.4 aut |
| 700 | 1 | a Mendes, L. A.4 aut |
| 700 | 1 | a Niswender, K.4 aut |
| 700 | 1 | a Pechman, K. R.4 aut |
| 700 | 1 | a Rane, S.4 aut |
| 700 | 1 | a Ruberg, F. L.4 aut |
| 700 | 1 | a Su, Y. R.4 aut |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Liu, D. D.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Journal of Alzheimers Diseased : IOS Pressg 52:2, s. 539-559q 52:2<539-559x 1387-2877x 1875-8908 |
| 856 | 4 | u https://europepmc.org/articles/pmc4866875?pdf=render |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/238539 |
| 856 | 4 8 | u https://doi.org/10.3233/jad-150914 |
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