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WFRF:(Söderberg Nauclér Cecilia)
 

Search: WFRF:(Söderberg Nauclér Cecilia) > Intragraft Cytomega...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003695naa a2200445 4500
001oai:DiVA.org:uu-159724
003SwePub
008111007s2011 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:123439016
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1597242 URI
0247 a https://doi.org/10.1093/cid/cir6192 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1234390162 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Dzabic, Mensuru Karolinska Institutet4 aut
2451 0a Intragraft Cytomegalovirus Protein Expression Is Associated With Reduced Renal Allograft Survival
264 c 2011-09-29
264 1b Oxford University Press (OUP),c 2011
338 a print2 rdacarrier
520 a Background: Cytomegalovirus (CMV) infection is a risk factor for acute and chronic rejection of transplanted organs and is thought to mediate rejection indirectly. Methods: In this retrospective observational cohort study, early- and end-stage biopsies from renal allografts lost because of chronic allograft dysfunction (n = 29) were examined for CMV antigens and DNA using immunohistochemistry, in situ hybridization, and real-time polymerase chain reaction. Results: CMV immediate-early and late proteins were present in 27 (93%) of 29 of the end-stage chronic allograft dysfunction biopsies and in 64% of the corresponding early biopsies but not in pretransplant biopsies from CMV-seronegative donors (n = 3). Graft survival time was reduced in patients with moderate or high CMV levels in the graft soon after transplantation compared with that in patients with no or low CMV levels in the graft. No significant difference was observed in serum creatinine obtained at the time of early biopsies. Conclusions: We provide evidence that intragraft CMV protein expression is associated with end-stage chronic renal allograft dysfunction, that intragraft CMV levels increase as graft function deteriorates, and that CMV protein expression in the grafts soon after transplant is associated with reduced graft survival. Thus, CMV may have a pathological role in chronic renal allograft dysfunction.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a Pathology
653 a Patologi
7001 a Rahbar, Afsaru Karolinska Institutet4 aut
7001 a Yaiw, Koon-Chuu Karolinska Institutet4 aut
7001 a Naghibi, Mansouru Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut
7001 a Religa, Piotru Karolinska Institutet4 aut
7001 a Fellström, Bengtu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)bengfell
7001 a Larsson, Eriku Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)eriklars
7001 a Söderberg-Nauclér, Ceciliau Karolinska Institutet4 aut
7102 a Karolinska Institutetb Institutionen för immunologi, genetik och patologi4 org
7730 t Clinical Infectious Diseasesd : Oxford University Press (OUP)g 53:10, s. 969-976q 53:10<969-976x 1058-4838x 1537-6591
8564 u https://academic.oup.com/cid/article-pdf/53/10/969/952168/cir619.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159724
8564 8u https://doi.org/10.1093/cid/cir619
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:123439016

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