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Sökning: WFRF:(Sala Joan) > (2020-2024) > Mitochondrial Dysfu...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004850naa a2200505 4500
001oai:lup.lub.lu.se:88553901-9e48-4ead-a8f2-dfabae31b542
003SwePub
008230901s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/88553901-9e48-4ead-a8f2-dfabae31b5422 URI
0247 a https://doi.org/10.3390/cells121620842 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Mercader-Barceló, Josepu Instituto de Investigación sanitaria Illes Balears (idISBA)4 aut
2451 0a Mitochondrial Dysfunction in Lung Resident Mesenchymal Stem Cells from Idiopathic Pulmonary Fibrosis Patients
264 1c 2023
520 a Idiopathic pulmonary fibrosis (IPF) is characterized by an aberrant repair response with uncontrolled turnover of extracellular matrix involving mesenchymal cell phenotypes, where lung resident mesenchymal stem cells (LRMSC) have been supposed to have an important role. However, the contribution of LRMSC in lung fibrosis is not fully understood, and the role of LRMSC in IPF remains to be elucidated. Here, we performed transcriptomic and functional analyses on LRMSC isolated from IPF and control patients (CON). Both over-representation and gene set enrichment analyses indicated that oxidative phosphorylation is the major dysregulated pathway in IPF LRMSC. The most relevant differences in biological processes included complement activation, mesenchyme development, and aerobic electron transport chain. Compared to CON LRMSC, IPF cells displayed impaired mitochondrial respiration, lower expression of genes involved in mitochondrial dynamics, and dysmorphic mitochondria. These changes were linked to an impaired autophagic response and a lower mRNA expression of pro-apoptotic genes. In addition, IPF TGFβ-exposed LRMSC presented different expression profiles of mitochondrial-related genes compared to CON TGFβ-treated cells, suggesting that TGFβ reinforces mitochondrial dysfunction. In conclusion, these results suggest that mitochondrial dysfunction is a major event in LRMSC and that their occurrence might limit LRMSC function, thereby contributing to IPF development.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
653 a Humans
653 a Idiopathic Pulmonary Fibrosis/genetics
653 a Autophagy
653 a Mesenchymal Stem Cells
653 a Mitochondria
653 a Lung
7001 a Martín-Medina, Ainau Instituto de Investigación sanitaria Illes Balears (idISBA)4 aut
7001 a Truyols-Vives, Joanu University of the Balearic Islands4 aut
7001 a Escarrer-Garau, Gabrielu University of the Balearic Islands4 aut
7001 a Elowsson, Lindau Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups4 aut0 (Swepub:lu)biot-lel
7001 a Montes-Worboys, Anau Bellvitge University Hospital-IDIBELL4 aut
7001 a Río-Bocos, Carlosu Instituto de Investigación sanitaria Illes Balears (idISBA)4 aut
7001 a Muncunill-Farreny, Josepu Instituto de Investigación sanitaria Illes Balears (idISBA)4 aut
7001 a Velasco-Roca, Juliou Instituto de Investigación sanitaria Illes Balears (idISBA)4 aut
7001 a Cederberg, Annau Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups4 aut0 (Swepub:lu)an1510ce
7001 a Kadefors, Månsu Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups4 aut0 (Swepub:lu)immu-mkr
7001 a Molina-Molina, Mariau Bellvitge University Hospital-IDIBELL4 aut
7001 a Westergren-Thorsson, Gunillau Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,WCMM- Wallenberg center för molekylär medicinsk forskning,Lung Biology,Lund University Research Groups,Faculty of Medicine,WCMM-Wallenberg Centre for Molecular Medicine4 aut0 (Swepub:lu)medk-gwt
7001 a Sala-Llinàs, Ernestu Instituto de Investigación sanitaria Illes Balears (idISBA)4 aut
7102 a Instituto de Investigación sanitaria Illes Balears (idISBA)b University of the Balearic Islands4 org
7730 t Cellsg 12:16, s. 1-18q 12:16<1-18x 2073-4409
8564 u http://dx.doi.org/10.3390/cells12162084x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/88553901-9e48-4ead-a8f2-dfabae31b542
8564 8u https://doi.org/10.3390/cells12162084

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