Fluorescent nucleobase analogues for base-base FRET in nucleic acids: Synthesis, photophysics and applications

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Fältnamn	Indikatorer	Metadata
000		04703naa a2200565 4500
001		oai:gup.ub.gu.se/264212
003		SwePub
008		240528s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:research.chalmers.se:f5d732df-47d7-49b4-b2b2-d36c1f48be1d
024	7	a https://gup.ub.gu.se/publication/2642122 URI
024	7	a https://doi.org/10.3762/bjoc.14.72 DOI
024	7	a https://research.chalmers.se/publication/5004582 URI
040		a (SwePub)gud (SwePub)cth
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Bood, Mattiasu Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg4 aut0 (Swepub:gu)xbooma
245	1 0	a Fluorescent nucleobase analogues for base-base FRET in nucleic acids: Synthesis, photophysics and applications
264		c 2018-01-10
264	1	b Beilstein Institut,c 2018
520		a Forster resonance energy transfer (FRET) between a donor nucleobase analogue and an acceptor nucleobase analogue, base-base FRET, works as a spectroscopic ruler and protractor. With their firm stacking and ability to replace the natural nucleic acid bases inside the base-stack, base analogue donor and acceptor molecules complement external fluorophores like the Cy-, Alexa- and ATTO-dyes and enable detailed investigations of structure and dynamics of nucleic acid containing systems. The first base-base FRET pair, tCO-tCnitro, has recently been complemented with among others the adenine analogue FRET pair, qAN1-qAnitro, increasing the flexibility of the methodology. Here we present the design, synthesis, photophysical characterization and use of such base analogues. They enable a higher control of the FRET orientation factor, κ2, have a different distance window of opportunity than external fluorophores, and, thus, have the potential to facilitate better structure resolution. Netropsin DNA binding and the B-to-Z-DNA transition are examples of structure investigations that recently have been performed using base.base FRET and that are described here. Base-base FRET has been around for less than a decade, only in 2017 expanded beyond one FRET pair, and represents a highly promising structure and dynamics methodology for the field of nucleic acids. Here we bring up its advantages as well as disadvantages and touch upon potential future applications. © 2018 Bood et al.
650	7	a NATURVETENSKAPx Kemix Organisk kemi0 (SwePub)104052 hsv//swe
650	7	a NATURAL SCIENCESx Chemical Sciencesx Organic Chemistry0 (SwePub)104052 hsv//eng
650	7	a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
650	7	a NATURVETENSKAPx Kemix Fysikalisk kemi0 (SwePub)104022 hsv//swe
650	7	a NATURAL SCIENCESx Chemical Sciencesx Physical Chemistry0 (SwePub)104022 hsv//eng
650	7	a NATURVETENSKAPx Biologix Biofysik0 (SwePub)106032 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Biophysics0 (SwePub)106032 hsv//eng
653		a B-to-Z-DNA transition
653		a Fluorescent base analogues
653		a FRET
653		a Netropsin
653		a Nucleic acid structure and dynamics
653		a Quadracyclic adenines
653		a Tricyclic cytosines
653		a Z-DNA
653		a FRET
700	1	a Sarangamath, Sangamesh,d 1992u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)sansar
700	1	a Sandberg Wranne, Moa,d 1986u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)moasan
700	1	a Grøtli, Morten,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg4 aut0 (Swepub:cth)grotli
700	1	a Wilhelmsson, Marcus,d 1974u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)mawi
710	2	a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org
773	0	t Beilstein Journal of Organic Chemistryd : Beilstein Institutg 14, s. 114-129q 14<114-129x 1860-5397
856	4	u https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-14-7.pdf
856	4	u https://research.chalmers.se/publication/500458/file/500458_Fulltext.pdfx primaryx freey FULLTEXT
856	4 8	u https://gup.ub.gu.se/publication/264212
856	4 8	u https://doi.org/10.3762/bjoc.14.7
856	4 8	u https://research.chalmers.se/publication/500458

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Av författaren/redakt...: Bood, Mattias; Sarangamath, San ...; Sandberg Wranne, ...; Grøtli, Morten, ...; Wilhelmsson, Mar ...

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