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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005750naa a2200565 4500
001oai:DiVA.org:uu-495407
003SwePub
008230127s2023 | |||||||||||000 ||eng|
009oai:DiVA.org:su-214507
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4954072 URI
0247 a https://doi.org/10.3390/molecules280102122 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2145072 URI
040 a (SwePub)uud (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Khan, Farooq-Ahmadu Univ Karachi, Third World Ctr Sci & Technol, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.;Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.4 aut
2451 0a Designing Functionally Substituted Pyridine-Carbohydrazides for Potent Antibacterial and Devouring Antifungal Effect on Multidrug Resistant (MDR) Strains
264 c 2022-12-26
264 1b MDPI,c 2023
338 a electronic2 rdacarrier
520 a The emergence of multidrug-resistant (MDR) pathogens and the gradual depletion of available antibiotics have exacerbated the need for novel antimicrobial agents with minimal toxicity. Herein, we report functionally substituted pyridine carbohydrazide with remarkable antimicrobial effect on multi-drug resistant strains. In the series, compound 6 had potent activity against four MDR strains of Candida spp., with minimum inhibitory concentration (MIC) values being in the range of 16-24 mu g/mL and percentage inhibition up to 92.57%, which was exceptional when compared to broad-spectrum antifungal drug fluconazole (MIC = 20 mu g/mL, 81.88% inhibition). Substitution of the octyl chain in 6 with a shorter butyl chain resulted in a significant anti-bacterial effect of 4 against Pseudomonas aeruginosa (ATCC 27853), the MIC value being 2-fold superior to the standard combination of ampicillin/cloxacillin. Time-kill kinetics assays were used to discern the efficacy and pharmacodynamics of the potent compounds. Further, hemolysis tests confirmed that both compounds had better safety profiles than the standard drugs. Besides, molecular docking simulations were used to further explore their mode of interaction with target proteins. Overall results suggest that these compounds have the potential to become promising antimicrobial drugs against MDR strains.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653 a multidrug resistance
653 a MDR strains
653 a antibiotics resistance
653 a antimicrobial
653 a pyridine
7001 a Yaqoob, Sanau Univ Karachi, Third World Ctr Sci & Technol, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.;Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.4 aut
7001 a Ali, Shujaatu Univ Karachi, Third World Ctr Sci & Technol, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.;Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.4 aut
7001 a Tanveer, Nimrau Univ Karachi, Third World Ctr Sci & Technol, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.;Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.4 aut
7001 a Wang, Yanu Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.4 aut
7001 a Ashraf, Sajdau Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.4 aut
7001 a Hasan, Khwaja Aliu Univ Karachi, Dept Biochem, Mol & Struct Biol Res Lab, Karachi 75270, Pakistan.4 aut
7001 a Khalifa, Shaden A. M.u Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.4 aut0 (Swepub:su)shkha
7001 a Shou, Qiyangu Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou 310053, Peoples R China.4 aut
7001 a Ul-Haq, Zaheeru Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.4 aut
7001 a Jiang, Zi-Huau Lakehead Univ, Dept Chem, 955 Oliver Rd, Thunder Bay, ON P7B 5E1, Canada.4 aut
7001 a El-Seedi, Heshamu Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Peoples R China.;Jiangsu Univ, Jiangsu Educ Dept, Int Joint Res Lab Intelligent Agr & Agriprod Proc, Nanjing 210024, Peoples R China.,Farmakognosi4 aut0 (Swepub:uu)heels173
7102 a Univ Karachi, Third World Ctr Sci & Technol, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.;Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.b Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.4 org
7730 t Moleculesd : MDPIg 28:1q 28:1x 1431-5157x 1420-3049
8564 u https://doi.org/10.3390/molecules28010212y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1731666/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-495407
8564 8u https://doi.org/10.3390/molecules28010212
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-214507

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