Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.

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Fältnamn	Indikatorer	Metadata
000		08696naa a2202017 4500
001		oai:gup.ub.gu.se/297166
003		SwePub
008		240910s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2971662 URI
024	7	a https://doi.org/10.1371/journal.pgen.10087182 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Vogelezang, Suzanne4 aut
245	1 0	a Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
264		c 2020-10-12
264	1	b Public Library of Science (PLoS),c 2020
520		a The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
700	1	a Bradfield, Jonathan P4 aut
700	1	a Ahluwalia, Tarunveer S4 aut
700	1	a Curtin, John A4 aut
700	1	a Lakka, Timo A4 aut
700	1	a Grarup, Niels4 aut
700	1	a Scholz, Markus4 aut
700	1	a van der Most, Peter J4 aut
700	1	a Monnereau, Claire4 aut
700	1	a Stergiakouli, Evie4 aut
700	1	a Heiskala, Anni4 aut
700	1	a Horikoshi, Momoko4 aut
700	1	a Fedko, Iryna O4 aut
700	1	a Vilor-Tejedor, Natalia4 aut
700	1	a Cousminer, Diana L4 aut
700	1	a Standl, Marie4 aut
700	1	a Wang, Carol A4 aut
700	1	a Viikari, Jorma4 aut
700	1	a Geller, Frank4 aut
700	1	a Íñiguez, Carmen4 aut
700	1	a Pitkänen, Niina4 aut
700	1	a Chesi, Alessandra4 aut
700	1	a Bacelis, Jonas,d 1984u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xbacjo
700	1	a Yengo, Loic4 aut
700	1	a Torrent, Maties4 aut
700	1	a Ntalla, Ioanna4 aut
700	1	a Helgeland, Øyvind4 aut
700	1	a Selzam, Saskia4 aut
700	1	a Vonk, Judith M4 aut
700	1	a Zafarmand, Mohammed H4 aut
700	1	a Heude, Barbara4 aut
700	1	a Farooqi, Ismaa Sadaf4 aut
700	1	a Alyass, Akram4 aut
700	1	a Beaumont, Robin N4 aut
700	1	a Have, Christian T4 aut
700	1	a Rzehak, Peter4 aut
700	1	a Bilbao, Jose Ramon4 aut
700	1	a Schnurr, Theresia M4 aut
700	1	a Barroso, Inês4 aut
700	1	a Bønnelykke, Klaus4 aut
700	1	a Beilin, Lawrence J4 aut
700	1	a Carstensen, Lisbeth4 aut
700	1	a Charles, Marie-Aline4 aut
700	1	a Chawes, Bo4 aut
700	1	a Clément, Karine4 aut
700	1	a Closa-Monasterolo, Ricardo4 aut
700	1	a Custovic, Adnan4 aut
700	1	a Eriksson, Johan G4 aut
700	1	a Escribano, Joaquin4 aut
700	1	a Groen-Blokhuis, Maria4 aut
700	1	a Grote, Veit4 aut
700	1	a Gruszfeld, Dariusz4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Hansen, Torben4 aut
700	1	a Hattersley, Andrew T4 aut
700	1	a Hollensted, Mette4 aut
700	1	a Hottenga, Jouke-Jan4 aut
700	1	a Hyppönen, Elina4 aut
700	1	a Johansson, Stefan4 aut
700	1	a Joro, Raimo4 aut
700	1	a Kähönen, Mika4 aut
700	1	a Karhunen, Ville4 aut
700	1	a Kiess, Wieland4 aut
700	1	a Knight, Bridget A4 aut
700	1	a Koletzko, Berthold4 aut
700	1	a Kühnapfel, Andreas4 aut
700	1	a Landgraf, Kathrin4 aut
700	1	a Langhendries, Jean-Paul4 aut
700	1	a Lehtimäki, Terho4 aut
700	1	a Leinonen, Jaakko T4 aut
700	1	a Li, Aihuali4 aut
700	1	a Lindi, Virpi4 aut
700	1	a Lowry, Estelle4 aut
700	1	a Bustamante, Mariona4 aut
700	1	a Medina-Gomez, Carolina4 aut
700	1	a Melbye, Mads4 aut
700	1	a Michaelsen, Kim F4 aut
700	1	a Morgen, Camilla S4 aut
700	1	a Mori, Trevor A4 aut
700	1	a Nielsen, Tenna R H4 aut
700	1	a Niinikoski, Harri4 aut
700	1	a Oldehinkel, Albertine J4 aut
700	1	a Pahkala, Katja4 aut
700	1	a Panoutsopoulou, Kalliope4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Pennell, Craig E4 aut
700	1	a Power, Christine4 aut
700	1	a Reijneveld, Sijmen A4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Simpson, Angela4 aut
700	1	a Sly, Peter D4 aut
700	1	a Stokholm, Jakob4 aut
700	1	a Teo, Kook K4 aut
700	1	a Thiering, Elisabeth4 aut
700	1	a Timpson, Nicholas J4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a van Beijsterveldt, Catharina E M4 aut
700	1	a van Schaik, Barbera D C4 aut
700	1	a Vaudel, Marc4 aut
700	1	a Verduci, Elvira4 aut
700	1	a Vinding, Rebecca K4 aut
700	1	a Vogel, Mandy4 aut
700	1	a Zeggini, Eleftheria4 aut
700	1	a Sebert, Sylvain4 aut
700	1	a Lind, Mads V4 aut
700	1	a Brown, Christopher D4 aut
700	1	a Santa-Marina, Loreto4 aut
700	1	a Reischl, Eva4 aut
700	1	a Frithioff-Bøjsøe, Christine4 aut
700	1	a Meyre, David4 aut
700	1	a Wheeler, Eleanor4 aut
700	1	a Ong, Ken4 aut
700	1	a Nohr, Ellen A4 aut
700	1	a Vrijkotte, Tanja G M4 aut
700	1	a Koppelman, Gerard H4 aut
700	1	a Plomin, Robert4 aut
700	1	a Njølstad, Pål R4 aut
700	1	a Dedoussis, George D4 aut
700	1	a Froguel, Philippe4 aut
700	1	a Sørensen, Thorkild I A4 aut
700	1	a Jacobsson, Bo,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xjacbo
700	1	a Freathy, Rachel M4 aut
700	1	a Zemel, Babette S4 aut
700	1	a Raitakari, Olli4 aut
700	1	a Vrijheid, Martine4 aut
700	1	a Feenstra, Bjarke4 aut
700	1	a Lyytikäinen, Leo-Pekka4 aut
700	1	a Snieder, Harold4 aut
700	1	a Kirsten, Holger4 aut
700	1	a Holt, Patrick G4 aut
700	1	a Heinrich, Joachim4 aut
700	1	a Widén, Elisabeth4 aut
700	1	a Sunyer, Jordi4 aut
700	1	a Boomsma, Dorret I4 aut
700	1	a Järvelin, Marjo-Riitta4 aut
700	1	a Körner, Antje4 aut
700	1	a Davey Smith, George4 aut
700	1	a Holm, Jens-Christian4 aut
700	1	a Atalay, Mustafa4 aut
700	1	a Murray, Clare4 aut
700	1	a Bisgaard, Hans4 aut
700	1	a McCarthy, Mark I4 aut
700	1	a Jaddoe, Vincent W V4 aut
700	1	a Grant, Struan F A4 aut
700	1	a Felix, Janine F4 aut
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org
773	0	t PLoS geneticsd : Public Library of Science (PLoS)g 16:10q 16:10x 1553-7404
856	4	u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008718&type=printable
856	4 8	u https://gup.ub.gu.se/publication/297166
856	4 8	u https://doi.org/10.1371/journal.pgen.1008718

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Av författaren/redakt...: Vogelezang, Suza ...; Bradfield, Jonat ...; Ahluwalia, Tarun ...; Curtin, John A; Lakka, Timo A; Grarup, Niels; visa fler...; Scholz, Markus; van der Most, Pe ...; Monnereau, Clair ...; Stergiakouli, Ev ...; Heiskala, Anni; Horikoshi, Momok ...; Fedko, Iryna O; Vilor-Tejedor, N ...; Cousminer, Diana ...; Standl, Marie; Wang, Carol A; Viikari, Jorma; Geller, Frank; Íñiguez, Carmen; Pitkänen, Niina; Chesi, Alessandr ...; Bacelis, Jonas, ...; Yengo, Loic; Torrent, Maties; Ntalla, Ioanna; Helgeland, Øyvin ...; Selzam, Saskia; Vonk, Judith M; Zafarmand, Moham ...; Heude, Barbara; Farooqi, Ismaa S ...; Alyass, Akram; Beaumont, Robin ...; Have, Christian ...; Rzehak, Peter; Bilbao, Jose Ram ...; Schnurr, Theresi ...; Barroso, Inês; Bønnelykke, Klau ...; Beilin, Lawrence ...; Carstensen, Lisb ...; Charles, Marie-A ...; Chawes, Bo; Clément, Karine; Closa-Monasterol ...; Custovic, Adnan; Eriksson, Johan ...; Escribano, Joaqu ...; Groen-Blokhuis, ...; Grote, Veit; Gruszfeld, Dariu ...; Hakonarson, Hako ...; Hansen, Torben; Hattersley, Andr ...; Hollensted, Mett ...; Hottenga, Jouke- ...; Hyppönen, Elina; Johansson, Stefa ...; Joro, Raimo; Kähönen, Mika; Karhunen, Ville; Kiess, Wieland; Knight, Bridget ...; Koletzko, Bertho ...; Kühnapfel, Andre ...; Landgraf, Kathri ...; Langhendries, Je ...; Lehtimäki, Terho; Leinonen, Jaakko ...; Li, Aihuali; Lindi, Virpi; Lowry, Estelle; Bustamante, Mari ...; Medina-Gomez, Ca ...; Melbye, Mads; Michaelsen, Kim ...; Morgen, Camilla ...; Mori, Trevor A; Nielsen, Tenna R ...; Niinikoski, Harr ...; Oldehinkel, Albe ...; Pahkala, Katja; Panoutsopoulou, ...; Pedersen, Oluf; Pennell, Craig E; Power, Christine; Reijneveld, Sijm ...; Rivadeneira, Fer ...; Simpson, Angela; Sly, Peter D; Stokholm, Jakob; Teo, Kook K; Thiering, Elisab ...; Timpson, Nichola ...; Uitterlinden, An ...; van Beijsterveld ...; van Schaik, Barb ...; Vaudel, Marc; Verduci, Elvira; Vinding, Rebecca ...; Vogel, Mandy; Zeggini, Elefthe ...; Sebert, Sylvain; Lind, Mads V; Brown, Christoph ...; Santa-Marina, Lo ...; Reischl, Eva; Frithioff-Bøjsøe ...; Meyre, David; Wheeler, Eleanor; Ong, Ken; Nohr, Ellen A; Vrijkotte, Tanja ...; Koppelman, Gerar ...; Plomin, Robert; Njølstad, Pål R; Dedoussis, Georg ...; Froguel, Philipp ...; Sørensen, Thorki ...; Jacobsson, Bo, 1 ...; Freathy, Rachel ...; Zemel, Babette S; Raitakari, Olli; Vrijheid, Martin ...; Feenstra, Bjarke; Lyytikäinen, Leo ...; Snieder, Harold; Kirsten, Holger; Holt, Patrick G; Heinrich, Joachi ...; Widén, Elisabeth; Sunyer, Jordi; Boomsma, Dorret ...; Järvelin, Marjo- ...; Körner, Antje; Davey Smith, Geo ...; Holm, Jens-Chris ...; Atalay, Mustafa; Murray, Clare; Bisgaard, Hans; McCarthy, Mark I; Jaddoe, Vincent ...; Grant, Struan F ...; Felix, Janine F; visa färre...

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