WFRF:(Thomas Sushma)
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Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria
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- Nicholls, Thomas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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- Spahr, H. (author)
- Karolinska Institutet
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- Jiang, S. (author)
- Karolinska Institutet
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- Sharma, S. (author)
- Kauppila, J. H. K. (author)
- Jiang, M. (author)
- Kaever, V. (author)
- Rackham, O. (author)
- Filipovska, A. (author)
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- (creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
- In: Molecular Cell. - : Elsevier BV. - 1097-2765 .- 1097-4164. ; 76:5
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Oligoribonucleases are conserved enzymes that degrade short RNA molecules of up to 5 nt in length and are assumed to constitute the final stage of RNA turnover. Here we demonstrate that REXO2 is a specialized dinucleotide-degrading enzyme that shows no preference between RNA and DNA dinucleotide substrates. A heart- and skeletal-muscle-specific knockout mouse displays elevated dinucleotide levels and alterations in gene expression patterns indicative of aberrant dinucleotide-primed transcription initiation. We find that dinucleotides act as potent stimulators of mitochondrial transcription initiation in vitro. Our data demonstrate that increased levels of dinucleotides can be used to initiate transcription, leading to an increase in transcription levels from both mitochondrial promoters and other, nonspecific sequence elements in mitochondrial DNA. Efficient RNA turnover by REXO2 is thus required to maintain promoter specificity and proper regulation of transcription in mammalian mitochondria.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- escherichia-coli
- transcription initiation
- stranded-rna
- in-vitro
- oligoribonuclease
- polymerase
- DNA
- maintenance
- component
- model
- Biochemistry & Molecular Biology
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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