WFRF:(Westman Julia)
Sökning: WFRF:(Westman Julia) > The role of tryptop...
The role of tryptophan and its derivatives in musculoskeletal pains : A systematic review and meta-analysis
-
- Canales, Giancarlo De La Torre (författare)
- Karolinska Institutet, Sweden; Egas Moniz School of Health & Science, Portugal
-
- Al-Moraissi, Essam Ahmed (författare)
- Thamar University, Yemen
-
- Fatih, Tina (författare)
- Karolinska Institutet, Sweden
- visa fler...
- visa färre...
- (creator_code:org_t)
- 2024
- 2024
- Engelska.
- Ingår i: Journal of Oral Rehabilitation. - : John Wiley & Sons. - 1365-2842.
- Forskningsöversikt (refereegranskat)
Abstract
Ämnesord
Stäng
- Background: Studies present ambiguous findings regarding the role of tryptophan and its metabolites, kynurenine and serotonin in chronic musculoskeletal pain. This systematic review aimed to investigate the expression of tryptophan and its metabolites, serotonin and kynurenine in patients with local and generalized chronic musculoskeletal pain in comparison with pain-free controls.Methods: An electronic search was conducted in the databases MEDLINE, CINAHL, EMBASE, the Cochrane Central Registry of Controlled Trials (CENTRAL) and Web of Science for clinical and observational trials from the beginning of each database to 21 April 2023. Out of 6734 articles, a total of 17 studies were included; 12 studies were used in the meta-analysis of serotonin, 3 regarding tryptophan and 2 studies for a narrative synthesis regarding kynurenine. Risk of bias was assessed using the quality assessment tool for observational cohort and cross-sectional studies of the National Heart, Lung, and Blood Institute, while the certainty of evidence was by GRADE.Results: All included studies showed a low risk of bias. The meta-analysis showed lower blood levels of tryptophan (p < .001; very low quality of evidence) and higher blood levels of serotonin (p < .001; very low-quality evidence) in patients with generalized musculoskeletal pain, when compared to pain-free individuals. In local chronic musculoskeletal pain, there were higher blood levels of serotonin (p=.251; very low quality of evidence) compared to pain-free individuals. Regarding kynurenine, the studies reported both higher and lower blood levels in generalized chronic musculoskeletal pain compared to pain-free individuals.Conclusions: The blood levels of tryptophan and its metabolites serotonin and kynurenine seem to influence chronic musculoskeletal pain.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- chronic musculoskeletal pain
- human
- kynurenine
- serotonin
- tryptophan
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
- Journal of Oral Rehabilitation (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
Hitta mer i SwePub
- Av författaren/redakt...
- Canales, Giancar ...
- Al-Moraissi, Ess ...
- Fatih, Tina
- Razavian, Artin
- Westman, Julia
- Yanes, Yanal
- visa fler...
- Grigoriadis, Ana ...
- Christidis, Mari ...
- Christidis, Niko ...
- Barjandi, Golnaz
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Neurovetenskaper
- Artiklar i publikationen
- Journal of Oral ...
- Av lärosätet
- Röda Korsets Högskola
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
