Sökning: WFRF:(Westman Julia) > The role of tryptop...
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000 | 04146naa a2200481 4500 | |
001 | oai:DiVA.org:rkh-4878 | |
003 | SwePub | |
008 | 240613s2024 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:158327322 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-48782 URI |
024 | 7 | a https://doi.org/10.1111/joor.137582 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1583273222 URI |
040 | a (SwePub)rkhd (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a for2 swepub-publicationtype |
100 | 1 | a Canales, Giancarlo De La Torreu Karolinska Institutet4 aut |
245 | 1 0 | a The role of tryptophan and its derivatives in musculoskeletal pains :b A systematic review and meta-analysis |
264 | 1 | b John Wiley & Sons,c 2024 |
338 | a print2 rdacarrier | |
520 | a Background: Studies present ambiguous findings regarding the role of tryptophan and its metabolites, kynurenine and serotonin in chronic musculoskeletal pain. This systematic review aimed to investigate the expression of tryptophan and its metabolites, serotonin and kynurenine in patients with local and generalized chronic musculoskeletal pain in comparison with pain-free controls.Methods: An electronic search was conducted in the databases MEDLINE, CINAHL, EMBASE, the Cochrane Central Registry of Controlled Trials (CENTRAL) and Web of Science for clinical and observational trials from the beginning of each database to 21 April 2023. Out of 6734 articles, a total of 17 studies were included; 12 studies were used in the meta-analysis of serotonin, 3 regarding tryptophan and 2 studies for a narrative synthesis regarding kynurenine. Risk of bias was assessed using the quality assessment tool for observational cohort and cross-sectional studies of the National Heart, Lung, and Blood Institute, while the certainty of evidence was by GRADE.Results: All included studies showed a low risk of bias. The meta-analysis showed lower blood levels of tryptophan (p < .001; very low quality of evidence) and higher blood levels of serotonin (p < .001; very low-quality evidence) in patients with generalized musculoskeletal pain, when compared to pain-free individuals. In local chronic musculoskeletal pain, there were higher blood levels of serotonin (p=.251; very low quality of evidence) compared to pain-free individuals. Regarding kynurenine, the studies reported both higher and lower blood levels in generalized chronic musculoskeletal pain compared to pain-free individuals.Conclusions: The blood levels of tryptophan and its metabolites serotonin and kynurenine seem to influence chronic musculoskeletal pain. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a chronic musculoskeletal pain | |
653 | a human | |
653 | a kynurenine | |
653 | a serotonin | |
653 | a tryptophan | |
700 | 1 | a Al-Moraissi, Essam Ahmedu Thamar University, Yemen4 aut |
700 | 1 | a Fatih, Tinau Karolinska Institutet, Sweden4 aut |
700 | 1 | a Razavian, Artinu Karolinska Institutet, Sweden4 aut |
700 | 1 | a Westman, Juliau Karolinska Institutet, Sweden4 aut |
700 | 1 | a Yanes, Yanalu Karolinska Institutet, Sweden4 aut |
700 | 1 | a Grigoriadis, Anastasiosu Karolinska Institutet4 aut |
700 | 1 | a Christidis, Maria,d 1982-u Röda Korsets Högskola,Hälsovetenskapliga institutionen,Karolinska Institutet, Sweden4 aut0 (Swepub:rkh)chrm |
700 | 1 | a Christidis, Nikolaosu Karolinska Institutet4 aut |
700 | 1 | a Barjandi, Golnazu Karolinska Institutet, Sweden4 aut |
710 | 2 | a Karolinska Institutetb Thamar University, Yemen4 org |
773 | 0 | t Journal of Oral Rehabilitationd : John Wiley & Sonsg 51:9, s. 1898-1910q 51:9<1898-1910x 1365-2842 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-4878 |
856 | 4 8 | u https://doi.org/10.1111/joor.13758 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:158327322 |
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