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Sökning: WFRF:(Yang Chengkun) > (2019) > Integrated analysis...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008507naa a2200649 4500
001oai:DiVA.org:kth-254121
003SwePub
008190624s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2541212 URI
0247 a https://doi.org/10.7150/jca.299862 DOI
040 a (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Liao, Xiwenu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
2451 0a Integrated analysis of competing endogenous RNA network revealing potential prognostic biomarkers of hepatocellular carcinoma
264 1b Ivyspring International Publisher,c 2019
338 a print2 rdacarrier
500 a QC 20190624
520 a Objective: The goal of our study is to identify a competing endogenous RNA (ceRNA) network using dysregulated RNAs between HCC tumors and the adjacent normal liver tissues from The Cancer Genome Atlas (TCGA) datasets, and to investigate underlying prognostic indicators in hepatocellular carcinoma (HCC) patients. Methods: All of the RNA- and miRNA-sequencing datasets of HCC were obtained from TCGA, and dysregulated RNAs between HCC tumors and the adjacent normal liver tissues were investigated by DESeq and edgeR algorithm. Survival analysis was used to confirm underlying prognostic indicators. Results: In the present study, we constructed a ceRNA network based on 16 differentially expressed genes (DEGs), 7 differentially expressed microRNAs and 34 differentially expressed long non-coding RNAs (DELs). Among these dysregulated RNAs, three DELs (AP002478.1, HTR2A-AS1, and ERVMER61-1) and six DEGs (enhancer of zeste homolog 2 [EZH2], kinesin family member 23 [KIF23], chromobox 2 [CBX2], centrosomal protein 55 [CEP55], cell division cycle 25A [CDC25A], and claspin [CLSPN]) were used for construct a prognostic signature for HCC overall survival (OS), and performed well in HCC OS (adjusted P<0.0001, adjusted hazard ratio = 2.761, 95% confidence interval = 1.838-4.147). Comprehensive survival analysis demonstrated that this prognostic signature may be act as an independent prognostic indicator of HCC OS. Functional assessment of these dysregulated DEGs in the ceRNA network and gene set enrichment of this prognostic signature suggest that both were enriched in the biological processes and pathways of the cell cycle, cell division and cell proliferation. Conclusions: Our current study constructed a ceRNA network for HCC, and developed a prognostic signature that may act as an independent indicator for HCC OS.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a competing endogenous RNA
653 a hepatocellular carcinoma
653 a bioinformatics
653 a prognosis
653 a TCGA
7001 a Wang, Xiangkunu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Huang, Ketuanu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Han, Chuangyeu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Deng, Jianlongu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 6, Dept Hepatobiliary Surg, Yulin 537000, Guangxi Zhuang, Peoples R China.4 aut
7001 a Yu, Tingdongu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Yang, Chengkunu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Huang, Ruiu Guangxi Med Univ, Affiliated Hosp 1, Dept Hematol, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Liu, Xiaoguangu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Guangdong Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp, Zhanjiang 524001, Guangdong, Peoples R China.4 aut
7001 a Yu, Longu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Zhengzhou 450000, Henan, Peoples R China.4 aut
7001 a Zhu, Guangzhiu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Su, Haou Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Qin, Weiu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Zeng, Xianminu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Han, Bowenu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Han, Quanfau Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Liu, Zhengqianu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Zhou, Xinu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Gong, Yizhenu Guangxi Med Univ, Affiliated Hosp 1, Dept Colorectal & Anal Surg, Nanning 530021, Guangxi Zhuang, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 1, Dept Evidence Based Med, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Liu, Zhengtaou KTH,Science for Life Laboratory, SciLifeLab,Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Minist Publ Hlth, Key Lab Combined Multiorgan Transplantat, Hangzhou 310003, Zhejiang, Peoples R China.;Key Lab Organ Transplantat Zhejiang Prov, Hangzhou 310003, Zhejiang, Peoples R China4 aut0 (Swepub:kth)u1ju7n8n
7001 a Huang, Jianlyu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 3, Dept Hepatobiliary Surg, Nanning 530031, Guangxi Zhuang, Peoples R China.4 aut
7001 a Winkler, Cheryl A.u NCI, Basic Res Lab, CCR, Frederick Natl Lab, Frederick, MD 21702 USA.;Frederick Natl Lab, Leidos Biomed Res, Frederick, MD 21702 USA.4 aut
7001 a O'Brien, Stephen J.u St Petersburg State Univ, Theodosius Dobzhansky Ctr Genome Bioinformat, St Petersburg 199004, Russia.;Nova Southeastern Univ, Oceanog Ctr, Ft Lauderdale, FL 33004 USA.4 aut
7001 a Ye, Xinpingu Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7001 a Peng, Taou Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.4 aut
7102 a Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.b Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 6, Dept Hepatobiliary Surg, Yulin 537000, Guangxi Zhuang, Peoples R China.4 org
7730 t Journal of Cancerd : Ivyspring International Publisherg 10:14, s. 3267-3283q 10:14<3267-3283x 1837-9664
8564 u https://www.jcancer.org/v10p3267.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-254121
8564 8u https://doi.org/10.7150/jca.29986

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