SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(You Dongfang)
 

Search: WFRF:(You Dongfang) > Trans-omics biomark...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005311naa a2200673 4500
001oai:lup.lub.lu.se:3d812759-1784-441f-9e44-605fa0ee35bf
003SwePub
008190918s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/3d812759-1784-441f-9e44-605fa0ee35bf2 URI
0247 a https://doi.org/10.18632/aging.1021892 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Dong, Xuesiu Nanjing Medical University,Southeast University4 aut
2451 0a Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma
264 c 2019-08-21
264 1b Impact Journals, LLC,c 2019
300 a 24 s.
520 a Limited studies have focused on developing prognostic models with trans-omics biomarkers for early-stage lung adenocarcinoma (LUAD). We performed integrative analysis of clinical information, DNA methylation, and gene expression data using 825 early-stage LUAD patients from 5 cohorts. Ranger algorithm was used to screen prognosis-associated biomarkers, which were confirmed with a validation phase. Clinical and biomarker information was fused using an iCluster plus algorithm, which significantly distinguished patients into high- and low-mortality risk groups (Pdiscovery = 0.01 and Pvalidation = 2.71×10-3). Further, potential functional DNA methylation-gene expression-overall survival pathways were evaluated by causal mediation analysis. The effect of DNA methylation level on LUAD survival was significantly mediated through gene expression level. By adding DNA methylation and gene expression biomarkers to a model of only clinical data, the AUCs of the trans-omics model improved by 18.3% (to 87.2%) and 16.4% (to 85.3%) in discovery and validation phases, respectively. Further, concordance index of the nomogram was 0.81 and 0.77 in discovery and validation phases, respectively. Based on systematic review of published literatures, our model was superior to all existing models for early-stage LUAD. In summary, our trans-omics model may help physicians accurately identify patients with high mortality risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a DNA methylation
653 a early-stage
653 a gene expression
653 a lung adenocarcinoma
653 a prognostic prediction
7001 a Zhang, Ruyangu Harvard University,Nanjing Medical University,Nanjing University4 aut
7001 a He, Jieyuu Nanjing Medical University4 aut
7001 a Lai, Linjingu Nanjing Medical University4 aut
7001 a Alolga, Raphael N.u China Pharmaceutical University4 aut
7001 a Shen, Sipengu Nanjing Medical University,Harvard University4 aut
7001 a Zhu, Yingu Nanjing Medical University4 aut
7001 a You, Dongfangu Nanjing Medical University4 aut
7001 a Lin, Lijuanu Nanjing Medical University4 aut
7001 a Chen, Chaou Nanjing Medical University4 aut
7001 a Zhao, Yangu Nanjing Medical University4 aut
7001 a Duan, Weiweiu Nanjing Medical University4 aut
7001 a Su, Liu Nanjing Medical University,Harvard University4 aut
7001 a Shafer, Andreau Massachusetts General Hospital,Harvard University4 aut
7001 a Salama, Moranu Bellvitge Biomedical Research Institute,University of Barcelona4 aut
7001 a Fleischer, Thomasu Oslo university hospital4 aut
7001 a Bjaanæs, Maria Moksnesu Oslo university hospital4 aut
7001 a Karlsson, Annau Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups4 aut0 (Swepub:lu)med-akn
7001 a Planck, Mariau Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups4 aut0 (Swepub:lu)onk-mpl
7001 a Wang, Ruiu Nanjing University4 aut
7001 a Staaf, Johanu Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups4 aut0 (Swepub:lu)onk-jst
7001 a Helland, Åslaugu Oslo university hospital,University of Oslo4 aut
7001 a Esteller, Manelu Bellvitge Biomedical Research Institute,University of Barcelona4 aut
7001 a Wei, Yongyueu Nanjing Medical University,Harvard University4 aut
7001 a Chen, Fengu Nanjing Medical University,Southeast University4 aut
7001 a Christiani, David C.u Harvard University,Massachusetts General Hospital,Nanjing Medical University4 aut
7102 a Nanjing Medical Universityb Southeast University4 org
7730 t Agingd : Impact Journals, LLCg 11:16, s. 6312-6335q 11:16<6312-6335x 1945-4589
8564 u http://dx.doi.org/10.18632/aging.102189x freey FULLTEXT
8564 u https://doi.org/10.18632/aging.102189
8564 8u https://lup.lub.lu.se/record/3d812759-1784-441f-9e44-605fa0ee35bf
8564 8u https://doi.org/10.18632/aging.102189

Find in a library

  • Aging (Search for host publication in LIBRIS)

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view