WFRF:(Yovos J)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03797naa a2200445 4500 | |
| 001 | oai:lup.lub.lu.se:44c89fb6-2bb8-43e3-b81f-93433d37bbd4 | |
| 003 | SwePub | |
| 008 | 160401s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/6889342 URI |
| 024 | 7 | a https://doi.org/10.1038/sj.jhh.10022012 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Sarafidis, P. A.4 aut |
| 245 | 1 0 | a Validity and reproducibility of HOMA-IR, 1/HOMA-IR, QUICKI and McAuley's indices in patients with hypertension and type II diabetes |
| 264 | c 2007-04-19 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2007 |
| 520 | a The aim of this study was to evaluate the validity and reliability of homeostasis model assessment-insulin resistance (HOMA-IR) index, its reciprocal (1/HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and McAuley's index in hypertensive diabetic patients. In 78 patients with hypertension and type II diabetes glucose, insulin and triglyceride levels were determined after a 12-h fast to calculate these indices, and insulin sensitivity (IS) was measured with the hyperinsulinemic euglycemic clamp technique. Two weeks later, subjects had again their glucose, insulin and triglycerides measured. Simple and multiple linear regression analysis were applied to assess the validity of these indices compared to clamp IS and coefficients of variation between the two visits were estimated to assess their reproducibility. HOMA-IR index was strongly and inversely correlated with the basic IS clamp index, the M-value (r = 0.572, P < 0.001), M- value normalized with subjects' body weight or fat-free mass and every other clamp-derived index. 1/HOMA-IR and QUICKI indices were positively correlated with the M- value (r = 0.342, P < 0.05 and r = 0.456, P < 0.01, respectively) and the rest clamp indices. McAuley's index generally presented less strong correlations ( r = 0.317, P < 0.05 with M- value). In multivariate analysis, HOMA-IR was the best fit of clampderived IS. Coefficients of variation between the two visits were 23.5% for HOMA-IR, 19.2% for 1/HOMA-IR, 7.8% for QUICKI and 15.1% for McAuley's index. In conclusion, HOMA- IR, 1/HOMA-IR and QUICKI are valid estimates of clamp-derived IS in patients with hypertension and type II diabetes, whereas the validity of McAuley's index needs further evaluation. QUICKI displayed better reproducibility than the other indices. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a QUICKI | |
| 653 | a insulin resistance | |
| 653 | a HOMA-IR | |
| 653 | a McAuley's index | |
| 700 | 1 | a Lasaridis, A. N.4 aut |
| 700 | 1 | a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni |
| 700 | 1 | a Pikilidou, M. I.4 aut |
| 700 | 1 | a Stafilas, P. C.4 aut |
| 700 | 1 | a Kanaki, A.4 aut |
| 700 | 1 | a Kazakos, K.4 aut |
| 700 | 1 | a Yovos, J.4 aut |
| 700 | 1 | a Bakris, G. L.4 aut |
| 710 | 2 | a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Journal of Human Hypertensiond : Springer Science and Business Media LLCg 21:9, s. 709-716q 21:9<709-716x 1476-5527x 0950-9240 |
| 856 | 4 | u http://dx.doi.org/10.1038/sj.jhh.1002201y FULLTEXT |
| 856 | 4 | u https://www.nature.com/articles/1002201.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/688934 |
| 856 | 4 8 | u https://doi.org/10.1038/sj.jhh.1002201 |
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- Sarafidis, P. A.
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- Nilsson, Peter
- Pikilidou, M. I.
- Stafilas, P. C.
- Kanaki, A.
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