Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies

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Fältnamn	Indikatorer	Metadata
000		06162naa a2201213 4500
001		oai:DiVA.org:umu-144092
003		SwePub
008		180126s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1440922 URI
024	7	a https://doi.org/10.1373/clinchem.2017.2807012 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Huang, Tao4 aut
245	1 0	a Dairy Consumption and Body Mass Index Among Adults :b Mendelian Randomization Analysis of 184802 Individuals from 25 Studies
264		c 2018-01-01
264	1	b Oxford University Press (OUP),c 2018
338		a print2 rdacarrier
520		a BACKGROUND: Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined.METHODS: We performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene (LCT-13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between (a) dairy intake and BMI, (b) rs4988235 and dairy intake, and (c) rs4988235 and BMI in each study. The causal effect of dairy intake on BMI was quantified by IV estimators among 184802 participants from 25 studies.RESULTS: Higher dairy intake was associated with higher BMI (β = 0.03 kg/m2 per serving/day; 95% CI, 0.00–0.06; P = 0.04), whereas the LCT genotype with 1 or 2 T allele was significantly associated with 0.20 (95% CI, 0.14–0.25) serving/day higher dairy intake (P = 3.15 × 10−12) and 0.12 (95% CI, 0.06–0.17) kg/m2 higher BMI (P = 2.11 × 10−5). MR analysis showed that the genetically determined higher dairy intake was significantly associated with higher BMI (β = 0.60 kg/m2 per serving/day; 95% CI, 0.27–0.92; P = 3.0 × 10−4).CONCLUSIONS: The present study provides strong evidence to support a causal effect of higher dairy intake on increased BMI among adults.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
700	1	a Ding, Ming4 aut
700	1	a Bergholdt, Helle K. M.4 aut
700	1	a Wang, Tiange4 aut
700	1	a Heianza, Yoriko4 aut
700	1	a Sun, Dian-jianyi4 aut
700	1	a Frazier-Wood, Alexis C.4 aut
700	1	a Aslibekyan, Stella4 aut
700	1	a North, Kari E.4 aut
700	1	a Voortman, Trudy4 aut
700	1	a Graff, Mariaelisa4 aut
700	1	a Smith, Caren E.4 aut
700	1	a Lai, Chao-Qiang4 aut
700	1	a Varbo, Anette4 aut
700	1	a Lemaitre, Rozenn N.4 aut
700	1	a de Jonge, M. Ester A. L.4 aut
700	1	a Fumeron, Fredric4 aut
700	1	a Corella, Dolores4 aut
700	1	a Wang, Carol A.4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Overvad, Kim4 aut
700	1	a Sorensen, Thorkild I. A.4 aut
700	1	a Feitosa, Mary F.4 aut
700	1	a Wojczynski, Mary K.4 aut
700	1	a Kahonen, Mika4 aut
700	1	a Renström, Fridau Umeå universitet,Enheten för biobanksforskning,Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden4 aut0 (Swepub:umu)frre0001
700	1	a Psaty, Bruce M.4 aut
700	1	a Siscovick, David S.4 aut
700	1	a Barroso, Ines4 aut
700	1	a Johansson, Ingegerdu Umeå universitet,Institutionen för odontologi4 aut0 (Swepub:umu)injo0003
700	1	a Hernandez, Dena4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Bandinelli, Stefania4 aut
700	1	a Linneberg, Allan4 aut
700	1	a Zillikens, M. Carola4 aut
700	1	a Sandholt, Camilla Helene4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Hansen, Torben4 aut
700	1	a Schulz, Christina-Alexandra4 aut
700	1	a Sonestedt, Emily4 aut
700	1	a Orho-Melander, Marju4 aut
700	1	a Chen, Tzu-An4 aut
700	1	a Rotter, Jerome I.4 aut
700	1	a Allison, Mathew A.4 aut
700	1	a Rich, Stephen S.4 aut
700	1	a Sorli, Jose V.4 aut
700	1	a Coltell, Oscar4 aut
700	1	a Pennell, Craig E.4 aut
700	1	a Eastwood, Peter4 aut
700	1	a Hofman, Albert4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a van Rooij, Frank J. A.4 aut
700	1	a Chu, Audrey Y.4 aut
700	1	a Rose, Lynda M.4 aut
700	1	a Ridker, Paul M.4 aut
700	1	a Viikari, Jorma4 aut
700	1	a Raitakari, Olli4 aut
700	1	a Lehtimaki, Terho4 aut
700	1	a Mikkila, Vera4 aut
700	1	a Willett, Walter C.4 aut
700	1	a Wang, Yujie4 aut
700	1	a Tucker, Katherine L.4 aut
700	1	a Ordovas, Jose M.4 aut
700	1	a Kilpelainen, Tuomas O.4 aut
700	1	a Province, Michael A.4 aut
700	1	a Franks, Paul W.u Umeå universitet,Medicin,Department of Nutrition, Harvard School of Public Health, Boston, MA; Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden4 aut0 (Swepub:umu)pafr0003
700	1	a Arnett, Donna K.4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Toft, Ulla4 aut
700	1	a Ericson, Ulrika4 aut
700	1	a Franco, Oscar H.4 aut
700	1	a Mozaffarian, Dariush4 aut
700	1	a Hu, Frank B.4 aut
700	1	a Chasman, Daniel I.4 aut
700	1	a Nordestgaard, Borge G.4 aut
700	1	a Ellervik, Christina4 aut
700	1	a Qi, Lu4 aut
710	2	a Umeå universitetb Enheten för biobanksforskning4 org
773	0	t Clinical Chemistryd : Oxford University Press (OUP)g 64:1, s. 183-191q 64:1<183-191x 0009-9147x 1530-8561
856	4	u https://academic.oup.com/clinchem/article-pdf/64/1/183/32642112/clinchem0183.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144092
856	4 8	u https://doi.org/10.1373/clinchem.2017.280701

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Av författaren/redakt...: Huang, Tao; Ding, Ming; Bergholdt, Helle ...; Wang, Tiange; Heianza, Yoriko; Sun, Dian-jianyi; visa fler...; Frazier-Wood, Al ...; Aslibekyan, Stel ...; North, Kari E.; Voortman, Trudy; Graff, Mariaelis ...; Smith, Caren E.; Lai, Chao-Qiang; Varbo, Anette; Lemaitre, Rozenn ...; de Jonge, M. Est ...; Fumeron, Fredric; Corella, Dolores; Wang, Carol A.; Tjonneland, Anne; Overvad, Kim; Sorensen, Thorki ...; Feitosa, Mary F.; Wojczynski, Mary ...; Kahonen, Mika; Renström, Frida; Psaty, Bruce M.; Siscovick, David ...; Barroso, Ines; Johansson, Ingeg ...; Hernandez, Dena; Ferrucci, Luigi; Bandinelli, Stef ...; Linneberg, Allan; Zillikens, M. Ca ...; Sandholt, Camill ...; Pedersen, Oluf; Hansen, Torben; Schulz, Christin ...; Sonestedt, Emily; Orho-Melander, M ...; Chen, Tzu-An; Rotter, Jerome I ...; Allison, Mathew ...; Rich, Stephen S.; Sorli, Jose V.; Coltell, Oscar; Pennell, Craig E ...; Eastwood, Peter; Hofman, Albert; Uitterlinden, An ...; van Rooij, Frank ...; Chu, Audrey Y.; Rose, Lynda M.; Ridker, Paul M.; Viikari, Jorma; Raitakari, Olli; Lehtimaki, Terho; Mikkila, Vera; Willett, Walter ...; Wang, Yujie; Tucker, Katherin ...; Ordovas, Jose M.; Kilpelainen, Tuo ...; Province, Michae ...; Franks, Paul W.; Arnett, Donna K.; Tanaka, Toshiko; Toft, Ulla; Ericson, Ulrika; Franco, Oscar H.; Mozaffarian, Dar ...; Hu, Frank B.; Chasman, Daniel ...; Nordestgaard, Bo ...; Ellervik, Christ ...; Qi, Lu; visa färre...

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