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SLC38A10 knockout m...
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Lindberg, Frida A.Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular Neuropharmacology
(author)
SLC38A10 knockout mice display a decreased body weight and an increased risk-taking behavior in the open field test
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-05-23
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Frontiers Media S.A.2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-473275
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-473275URI
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https://doi.org/10.3389/fnbeh.2022.840987DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The solute carrier 38 family (SLC38) is a family of 11 members. The most commonsubstrate among these are alanine and glutamine, and members are present in a widerange of tissues with important functions for several biological processes, such as liverand brain function. Some of these transporters are better characterized than others and,in this paper, a behavioral characterization of SLC38A10−/− mice was carried out. Abattery of tests for general activity, emotionality, motor function, and spatial memorywere used. Among these tests, the elevated plus maze, Y-maze, marble burying, andchallenging beamwalk have not been tested on the SLC38A10−/− mice previously, whilethe open field and the rotarod tests have been performed by the International MousePhenotyping Consortium (IMPC). Unlike the results from IMPC, the results from this studyshowed that SLC38A10−/− mice spend less time in the wall zone in the open field testthan WT mice, implying that SLC38A10-deficient mice have an increased explorativebehavior, which suggests an important function of SLC38A10 in brain. The present studyalso confirmed IMPC’s data regarding rotarod performance and weight, showing thatSLC38A10−/− mice do not have an affected motor coordination impairment and havea lower body weight than both SLC38A10+/− and SLC38A10+/+ mice. These resultsimply that a complete deficiency of the SLC38A10 protein might affect body weighthomeostasis, but the underlying mechanisms needs to be studied further.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Nordin, KarinUppsala universitet,Institutionen för farmaceutisk biovetenskap,Centrum för forsknings- och bioetik,Molecular Neuropharmacology(Swepub:uu)karinord
(author)
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Fredriksson, RobertUppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular Neuropharmacology(Swepub:uu)rfr20930
(author)
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Uppsala universitetInstitutionen för farmaceutisk biovetenskap
(creator_code:org_t)
Related titles
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In:Frontiers in Behavioral Neuroscience: Frontiers Media S.A.161662-5153
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