Sökning: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Medicinska och farmaceutiska grundvetenskaper) hsv:(Neurovetenskaper) > SLC38A10 knockout m...
Fältnamn | Indikatorer | Metadata |
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000 | 04473naa a2200529 4500 | |
001 | oai:DiVA.org:uu-473275 | |
003 | SwePub | |
008 | 220424s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4732752 URI |
024 | 7 | a https://doi.org/10.3389/fnbeh.2022.8409872 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lindberg, Frida A.u Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular Neuropharmacology4 aut0 (Swepub:uu)frili173 |
245 | 1 0 | a SLC38A10 knockout mice display a decreased body weight and an increased risk-taking behavior in the open field test |
264 | c 2022-05-23 | |
264 | 1 | b Frontiers Media S.A.c 2022 |
338 | a electronic2 rdacarrier | |
520 | a The solute carrier 38 family (SLC38) is a family of 11 members. The most commonsubstrate among these are alanine and glutamine, and members are present in a widerange of tissues with important functions for several biological processes, such as liverand brain function. Some of these transporters are better characterized than others and,in this paper, a behavioral characterization of SLC38A10−/− mice was carried out. Abattery of tests for general activity, emotionality, motor function, and spatial memorywere used. Among these tests, the elevated plus maze, Y-maze, marble burying, andchallenging beamwalk have not been tested on the SLC38A10−/− mice previously, whilethe open field and the rotarod tests have been performed by the International MousePhenotyping Consortium (IMPC). Unlike the results from IMPC, the results from this studyshowed that SLC38A10−/− mice spend less time in the wall zone in the open field testthan WT mice, implying that SLC38A10-deficient mice have an increased explorativebehavior, which suggests an important function of SLC38A10 in brain. The present studyalso confirmed IMPC’s data regarding rotarod performance and weight, showing thatSLC38A10−/− mice do not have an affected motor coordination impairment and havea lower body weight than both SLC38A10+/− and SLC38A10+/+ mice. These resultsimply that a complete deficiency of the SLC38A10 protein might affect body weighthomeostasis, but the underlying mechanisms needs to be studied further. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Andra medicinska och farmaceutiska grundvetenskaper0 (SwePub)301992 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Other Basic Medicine0 (SwePub)301992 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a SLC38A10 | |
653 | a SNAT10 | |
653 | a risk-taking behavior | |
653 | a solute carrier | |
653 | a open field | |
653 | a behavior | |
653 | a elevated plus maze | |
653 | a phenotyping | |
653 | a Pharmaceutical Science | |
653 | a Farmaceutisk vetenskap | |
700 | 1 | a Nordin, Karinu Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Centrum för forsknings- och bioetik,Molecular Neuropharmacology4 aut0 (Swepub:uu)karinord |
700 | 1 | a Fredriksson, Robertu Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molecular Neuropharmacology4 aut0 (Swepub:uu)rfr20930 |
710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
773 | 0 | t Frontiers in Behavioral Neuroscienced : Frontiers Media S.A.g 16q 16x 1662-5153 |
856 | 4 | u https://doi.org/10.3389/fnbeh.2022.840987y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1653758/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-473275 |
856 | 4 8 | u https://doi.org/10.3389/fnbeh.2022.840987 |
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