Sökning: L773:1010 4283 > Nuclisome :
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 02415naa a2200385 4500 | |
001 | oai:DiVA.org:uu-168821 | |
003 | SwePub | |
008 | 120216s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1688212 URI |
024 | 7 | a https://doi.org/10.1007/s13277-012-0341-32 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gedda, Larsu Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap4 aut0 (Swepub:uu)larsgedd |
245 | 1 0 | a Nuclisome :b targeting the tumor cell nucleus |
264 | c 2012-02-03 | |
264 | 1 | b Springer Science and Business Media LLC,c 2012 |
338 | a electronic2 rdacarrier | |
520 | a The Nuclisome concept builds on a novel two-step targeting strategy with the aim to deliver short-range Auger-electron-emitting radionuclides to nuclear DNA of tumor cells. The concept is based on the use of Nuclisome-particles, i.e., tumor-targeted PEG-stabilized liposomes loaded with a unique DNA-intercalating compound that enables specific and effective delivery of radionuclides to DNA. The specific and potent two-step targeting leads to eradication of tumor cells while toxicity to normal organs is reduced to a minimum. Results of in vitro and in vivo studies point towards the Nuclisome concept as a promising strategy for the treatment of small tumor masses and, in particular, for the elimination of spread single cells and micrometastases. | |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
653 | a Auger | |
653 | a Intercalator | |
653 | a Liposome | |
653 | a Radionuclide | |
653 | a DNA | |
700 | 1 | a Edwards, Katarinau Uppsala universitet,Analytisk kemi4 aut0 (Swepub:uu)kataedwa |
710 | 2 | a Uppsala universitetb Enheten för biomedicinsk strålningsvetenskap4 org |
773 | 0 | t Tumor Biologyd : Springer Science and Business Media LLCg 33:3, s. 661-667q 33:3<661-667x 1010-4283x 1423-0380 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:503569/FULLTEXT02.pdfx primaryx Raw objecty fulltext:postprint |
856 | 4 | u http://uu.diva-portal.org/smash/get/diva2:503569/FULLTEXT02 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-168821 |
856 | 4 8 | u https://doi.org/10.1007/s13277-012-0341-3 |
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