Long-term follow-up in lupus nephritis patients treated with rituximab: clinical and histopathological response

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: L773:1462 0332 OR L773:1460 2172 > (2010-2014) > Long-term follow-up...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		03897naa a2200409 4500
001		oai:DiVA.org:oru-70541
003		SwePub
008		190324s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:126667135
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-705412 URI
024	7	a https://doi.org/10.1093/rheumatology/kes3482 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1266671352 URI
040		a (SwePub)orud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Jónsdóttir, Thórunnu Department of Medicine, Rheumatology Unit, arolinska University Hospital, Karolinska Institutet, Stockholm, Sweden4 aut
245	1 0	a Long-term follow-up in lupus nephritis patients treated with rituximab :b clinical and histopathological response
264		c 2013-01-03
264	1	b Oxford University Press,c 2013
338		a print2 rdacarrier
520		a OBJECTIVE: To investigate the long-term clinical, histological and serological affects of B-cell-depleting therapy (BCDT) in patients with LN refractory to conventional treatment.METHODS: Twenty-five patients, followed for a mean time of 36 months (9-95 months), were included. Renal disease activity was evaluated with the BILAG index and renal response was determined according to the LN European consensus statement. Renal biopsies were performed for histological evaluation at baseline and follow-up.RESULTS: Partial response (PR) or complete renal response (CR) was observed in 22 of 25 after a median of 12 months. Sixteen patients achieved CR after a median of 24 months. Six patients experienced a renal relapse. Proteinuria decreased significantly (P = 0.0002) from baseline to 36 months. A noteworthy histological improvement was seen in nearly all patients with a significant reduction in activity index (P = 0.01). Longer depletion time and low baseline values of IgM were indicative of achieving clinical remission during the first year after treatment (P = 0.03 and P = 0.04, respectively).CONCLUSION: In therapy-resistant LN, BCDT induced clinical and histological improvements in the majority of patients. Transition from PR to CR was mainly seen during the second year of follow-up. Patients with longer depletion time and low baseline levels of IgM were more likely to gain a faster remission, suggesting that the clinical benefit may be linked to suppression of autoreactive plasmablasts. Although formal evidence of BCDT in LN is lacking, our data may provide guidance to clinicians considering therapeutic options in patients with refractory LN.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
700	1	a Zickert, Agnetau Karolinska Institutet4 aut
700	1	a Sundelin, Birgittau Karolinska Institutet4 aut
700	1	a Henriksson, Elisabet Welin,d 1960-u Karolinska Institutet4 aut0 (Swepub:oru)ebwn
700	1	a van Vollenhoven, Ronald F.u Karolinska Institutet4 aut
700	1	a Gunnarsson, Ivau Karolinska Institutet4 aut
710	2	a Karolinska Institutetb Department of Medicine, Rheumatology Unit, arolinska University Hospital, Karolinska Institutet, Stockholm, Sweden4 org
773	0	t Rheumatologyd : Oxford University Pressg 52:5, s. 847-855q 52:5<847-855x 1462-0324x 1462-0332
856	4	u https://doi.org/10.1093/rheumatology/kes348y Fulltext
856	4	u https://academic.oup.com/rheumatology/article-pdf/52/5/847/5138922/kes348.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70541
856	4 8	u https://doi.org/10.1093/rheumatology/kes348
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:126667135

Hitta via bibliotek

Rheumatology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Jónsdóttir, Thór ...; Zickert, Agneta; Sundelin, Birgit ...; Henriksson, Elis ...; van Vollenhoven, ...; Gunnarsson, Iva

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reumatologi och ...

Artiklar i publikationen: Rheumatology

Av lärosätet: Örebro universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se