L773:1873 5169 OR L773:0196 9781
Sökning: L773:1873 5169 OR L773:0196 9781 > Functional characte...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03892naa a2200349 4500 | |
| 001 | oai:slubar.slu.se:93490 | |
| 003 | SwePub | |
| 008 | 240410s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://res.slu.se/id/publ/934902 URI |
| 024 | 7 | a https://doi.org/10.1016/j.peptides.2017.10.0162 DOI |
| 040 | a (SwePub)slu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Christ, Peteru Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Växtskyddsbiologi,Department of Plant Protection Biology4 aut0 (Swepub:slu)96358 |
| 245 | 1 0 | a Functional characterization of the dual allatostatin-A receptors in mosquitoes |
| 264 | 1 | b Elsevier BV,c 2018 |
| 264 | 1 | b Elsevier,c 2024 |
| 520 | a The neuropeptide allatostatin-A (AstA) and its cognate receptors (AstARs) are involved in the modulation of feeding behavior, which in hematophagous insects includes the regulation of the disease vector-related behaviors, host seeking and blood feeding. In mosquitoes and other dipterans, there are two copies of AstAR, contrasting with the single copy found in other insects. In this study, we identified and cloned the dual AstAR system of two important disease vectors Aedes aegypti and Culex quinquefasciatus, and compared them with those previously described, including those in Anopheles coluzzii and Drosophila melanogaster. Phylogenetic analysis of the AstARs revealed that the mosquito AstAR1s has retained a similar amino acid sequence as the AstARs from non-dipteran insect species. Intron analysis revealed that the number of introns accumulated in the AstAR2s is similar to that in other insects, and that introns are conserved within the receptor types, but that only the final two introns are conserved across AstAR1s and 2s. We functionally characterized the dual AstARs in An. coluzzii, Ae. aegypti and Cx. quinquefasciatus by stably expressing the receptors in a Chinese hamster oocyte cell line (CHO) also stably expressing a promiscuous G-protein (G16), and challenged them with the endogenous isoforms of AstA from the three mosquito species. In the culicine mosquitoes, Ae. aegypti and Cx. quinquefasciatus, the AstARs demonstrated differential sensitivity to AstA, with the AstAR2s displaying a higher sensitivity than the AstAR1s, suggesting a divergence of functional roles for these AstARs. In contrast, both An. coluzzii AstARs demonstrated a similar sensitivity to the AstA ligands. We discuss our findings in the light of AstA acting as a regulator of blood feeding in mosquitoes. A better understanding of the regulation of host seeking and blood feeding in vector mosquitoes will lead to the rational development of novel approaches for vector control. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Zoologi0 (SwePub)106082 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Zoology0 (SwePub)106082 hsv//eng |
| 700 | 1 | a Hill, Sharonu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Växtskyddsbiologi,Department of Plant Protection Biology4 aut0 (Swepub:slu)51024 |
| 700 | 1 | a Ignell, Rickardu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Växtskyddsbiologi,Department of Plant Protection Biology4 aut0 (Swepub:slu)47630 |
| 710 | 2 | a Sveriges lantbruksuniversitetb Växtskyddsbiologi4 org |
| 710 | 2 | a Sveriges lantbruksuniversitet |
| 773 | 0 | t Peptidesd : Elsevier BVg 99, s. 44-55q 99<44-55x 0196-9781x 1873-5169 |
| 856 | 4 | u https://doi.org/10.1016/j.peptides.2017.10.016 |
| 856 | 4 8 | u https://res.slu.se/id/publ/93490 |
| 856 | 4 8 | u https://doi.org/10.1016/j.peptides.2017.10.016 |
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