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Sökning: WFRF:(Önnerfjord Patrik) > The skeletal phenot...

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FältnamnIndikatorerMetadata
00004967naa a2200445 4500
001oai:lup.lub.lu.se:ba8f4a73-44ad-45e9-a13b-5bec1f7972a9
003SwePub
008160401s2013 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/39134952 URI
0247 a https://doi.org/10.1371/journal.pone.00630802 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Hessle, Lovisau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-lhe
2451 0a The skeletal phenotype of chondroadherin deficient mice.
264 c 2013-06-03
264 1b Public Library of Science (PLoS),c 2013
338 a electronic2 rdacarrier
520 a Chondroadherin, a leucine rich repeat extracellular matrix protein with functions in cell to matrix interactions, binds cells via their α2β1 integrin as well as via cell surface proteoglycans, providing for different sets of signals to the cell. Additionally, the protein acts as an anchor to the matrix by binding tightly to collagens type I and II as well as type VI. We generated mice with inactivated chondroadherin gene to provide integrated studies of the role of the protein. The null mice presented distinct phenotypes with affected cartilage as well as bone. At 3-6 weeks of age the epiphyseal growth plate was widened most pronounced in the proliferative zone. The proteome of the femoral head articular cartilage at 4 months of age showed some distinct differences, with increased deposition of cartilage intermediate layer protein 1 and fibronectin in the chondroadherin deficient mice, more pronounced in the female. Other proteins show decreased levels in the deficient mice, particularly pronounced for matrilin-1, thrombospondin-1 and notably the members of the α1-antitrypsin family of proteinase inhibitors as well as for a member of the bone morphogenetic protein growth factor family. Thus, cartilage homeostasis is distinctly altered. The bone phenotype was expressed in several ways. The number of bone sialoprotein mRNA expressing cells in the proximal tibial metaphysic was decreased and the osteoid surface was increased possibly indicating a change in mineral metabolism. Micro-CT revealed lower cortical thickness and increased structure model index, i.e. the amount of plates and rods composing the bone trabeculas. The structural changes were paralleled by loss of function, where the null mice showed lower femoral neck failure load and tibial strength during mechanical testing at 4 months of age. The skeletal phenotype points at a role for chondroadherin in both bone and cartilage homeostasis, however, without leading to altered longitudinal growth.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Stordalen, Gunhild A4 aut
7001 a Wenglén, Christinau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-cla
7001 a Petzold, Christiane4 aut
7001 a Tanner, Elizabeth K4 aut
7001 a Brorson, Sverre-Henning4 aut
7001 a Baekkevold, Espen S4 aut
7001 a Önnerfjord, Patriku Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)akem-pon
7001 a Reinholt, Finn P4 aut
7001 a Heinegård, Dicku Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-dhe
7102 a Reumatologi och molekylär skelettbiologib Sektion III4 org
7730 t PLoS ONEd : Public Library of Science (PLoS)g 8:6q 8:6x 1932-6203
8564 u https://portal.research.lu.se/files/3827672/4091986.pdfx primaryx freey FULLTEXT
8564 u http://www.ncbi.nlm.nih.gov/pubmed/23755099?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1371/journal.pone.0063080y FULLTEXT
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0063080&type=printable
8564 8u https://lup.lub.lu.se/record/3913495
8564 8u https://doi.org/10.1371/journal.pone.0063080

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