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Low response rate t...
Low response rate to ATG-based immunosuppressive therapy in very severe aplastic anaemia : A Swedish nationwide cohort study
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- Vaht, Krista, 1973 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Sweden; Gothenburg Univ, Sweden,Institutionen för medicin,Institute of Medicine
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- Göransson, Magnus (författare)
- Department of Pediatrics, The Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Pediat, Queen Silvia Childrens Hosp, Gothenburg, Sweden
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- Carlson, Kristina (författare)
- Uppsala universitet,Hematologi,Uppsala University Hospital,Uppsala Univ Hosp, Sweden
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- Isaksson, Cecilia (författare)
- Department of Haematology, Cancer Centre, University Hospital, Umeå, Sweden,Univ Hosp, Dept Haematol, Ctr Canc, Umea, Sweden,Norrland University Hospital
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- Lenhoff, Stig (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden
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- Sandstedt, Anna (författare)
- Linköpings universitet,Institutionen för samhälls- och välfärdsstudier,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US
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- Uggla, Bertil, 1962- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Section of Haematology Department of Medicine,Orebro Univ, Sect Haematol, Dept Med, Fac Med & Hlth, Orebro, Sweden
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- Winiarski, Jacek (författare)
- Karolinska Institutet,Karolinska University Hospital,Karolinska Inst, Sweden; CLINTEC, Sweden
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- Ljungman, Per (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital,Karolinska Inst, Sweden
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- Brune, Mats, 1950 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Sweden; Gothenburg Univ, Sweden,Institutionen för medicin,Institute of Medicine
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- Andersson, Per-Ola, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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(creator_code:org_t)
- 2018-04-10
- 2018
- Engelska.
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Ingår i: European Journal of Haematology. - : Munksgaard Forlag. - 0902-4441 .- 1600-0609. ; 100:6, s. 613-620
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Objectives: Antithymocyte globulin (ATG)-based immunosuppression remains a cornerstone in aplastic anaemia (AA) treatment. However, most ATG studies are not population-based and knowledge about real-world results concerning response and outcome could offer important information for treating physicians.Methods: We have recently performed a nationwide retrospective cohort study on all AA patients diagnosed in Sweden in 2000–2011 and now present treatment and outcome data on patients receiving first-line ATG. In total, 158 patients showed a 47.0% response rate which was similar in all age groups (range 41.5%-51.7%) with no difference regarding ATG formulation. The response was significantly associated with severity grade—especially at time of treatment initiation: very severe (VSAA) 22.7%; severe (SAA) 54.5% (P <.001); and non-severe 88.5% (P <.001). A logistic regression-based predictive model indicated that VSAA patients with an absolute reticulocyte count <25 × 109/L had only a 19% probability of response. In a multivariable analysis, age and VSAA at the time of treatment were the independent factors for inferior survival.Conclusions: Real-world VSAA patients respond poorly to ATG which indicates the need for a different treatment approach. Our findings suggest that age alone should not be a discriminating factor for administering ATG treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Age
- antithymocyte globulin
- aplastic anaemia
- real-world data
- response rate
- Age
- Antithymocyte globulin
- Aplastic anaemia
- Real-world data
- Response rate
- age
- antithymocyte globulin
- aplastic anaemia
- real‐world data
- response rate
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Vaht, Krista, 19 ...
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Göransson, Magnu ...
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Carlson, Kristin ...
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Isaksson, Cecili ...
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Lenhoff, Stig
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Sandstedt, Anna
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Uggla, Bertil, 1 ...
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Winiarski, Jacek
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Ljungman, Per
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Brune, Mats, 195 ...
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Andersson, Per-O ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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European Journal ...
- Av lärosätet
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Örebro universitet
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet
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Linköpings universitet
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Göteborgs universitet