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  • Pedersen, Helle KroghNovo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland (författare)

Human gut microbes impact host serum metabolome and insulin sensitivity

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016-07-13
  • Nature Publishing Group,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-51849
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51849URI
  • https://doi.org/10.1038/nature18646DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:European Community HEALTH-F4-2007-201052Lundbeck Foundation Centre for Applied Medical Genomics in Personalized Disease Prediction, Prevention and Care (LuCamp), Metagenopolis grant ANR-11-DPBS-0001  HEALTH-F4-2012-305312Rega institute for Medical Research, KU LeuvenAgency for Innovation by Science and Technology (IWT) 267139Fund for Scientific Research Flanders (FWO)Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research) 250114EU FP7 Project TORNADO 222720European Union 600375Innovative Medicines Initiative Joint Undertaking from the European Union 115317
  • Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids. Prevotella copri and Bacteroides vulgatus are identified as the main species driving the association between biosynthesis of BCAAs and insulin resistance, and in mice we demonstrate that P. copri can induce insulin resistance, aggravate glucose intolerance and augment circulating levels of BCAAs. Our findings suggest that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gudmundsdottir, ValborgCenter for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark (författare)
  • Nielsen, Henrik BjornCenter for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark (författare)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Turku Centre for Biotechnology, Åbo Akademi University, Turku, Finland; Turku Centre for Biotechnology, University of Turku, Turku, Finland; VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)tihn (författare)
  • Nielsen, TrineNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
  • Jensen, Benjamin A. H.Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark (författare)
  • Forslund, KristofferEuropean Molecular Biology Laboratory, Heidelberg, Germany (författare)
  • Hildebrand, FalkEuropean Molecular Biology Laboratory, Heidelberg, Germany; Department of Bioscience Engineering, Vrije Universiteit Brussel, Brussels, Belgium; Center for the Biology of Disease, VIB, Leuven, Belgium (författare)
  • Prifti, EdiMGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France; Institute of Cardiometabolism and Nutrition (ICAN), Paris, France (författare)
  • Falony, GwenCenter for the Biology of Disease, VIB, Leuven, Belgium; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium (författare)
  • Le Chatelier, EmmanuelleMGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France (författare)
  • Levenez, FlorenceMGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France (författare)
  • Dore, JoelMGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France; Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France (författare)
  • Mattila, IsmoVTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark (författare)
  • Plichta, Damian R.Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark (författare)
  • Pöhö, PaiviVTT Technical Research Centre of Finland, Espoo, Finland; Faculty of Pharmacy, University of Helsinki, Helsinki, Finland (författare)
  • Hellgren, Lars I.Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark (författare)
  • Arumugam, ManimozhiyanNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
  • Sunagawa, ShinichiEuropean Molecular Biology Laboratory, Heidelberg, Germany; Institute of Microbiology, ETH Zurich, Zurich, Switzerland (författare)
  • Vieira-Silva, SaraCenter for the Biology of Disease, VIB, Leuven, Belgium; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium (författare)
  • Jørgensen, TorbenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Research Centre for Prevention and Health, Centre for Health, Capital Region, Glostrup Hospital, Glostrup, Denmark (författare)
  • Holm, Jacob BakLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark (författare)
  • Trost, KajetanSteno Diabetes Center, Gentofte, Denmark (författare)
  • Kristiansen, KarstenLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark; BGI-Shenzhen, Shenzhen, China (författare)
  • Brix, SusanneCenter for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark (författare)
  • Raes, JeroenDepartment of Bioscience Engineering, Vrije Universiteit Brussel, Brussels, Belgium; Center for the Biology of Disease, VIB, Leuven, Belgium; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium (författare)
  • Wang, JunLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark; BGI-Shenzhen, Shenzhen, China; Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia; Macau University of Science and Technology, Taipa, China; Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China (författare)
  • Hansen, TorbenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark (författare)
  • Bork, PeerEuropean Molecular Biology Laboratory, Heidelberg, Germany; Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany; Max Delbrück Centre for Molecular Medicine, Berlin, Germany; Department of Bioinformatics, University of Wuerzburg, Würzburg, Germany (författare)
  • Brunak, SørenCenter for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
  • Oresic, Matej,1967-Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland; VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark(Swepub:oru)moc (författare)
  • Ehrlich, S. DuskoCenter for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark; University of Örebro, Örebro, Sweden (författare)
  • Pedersen, OlufNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
  • Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, FinlandCenter for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature: Nature Publishing Group535:7612, s. 376-3810028-08361476-4687

Internetlänk

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  • Nature (Sök värdpublikationen i LIBRIS)

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