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FältnamnIndikatorerMetadata
00010236naa a2200709 4500
001oai:DiVA.org:oru-51849
003SwePub
008160829s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-518492 URI
0247 a https://doi.org/10.1038/nature186462 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Pedersen, Helle Kroghu Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland4 aut
2451 0a Human gut microbes impact host serum metabolome and insulin sensitivity
264 c 2016-07-13
264 1b Nature Publishing Group,c 2016
338 a print2 rdacarrier
500 a Funding Agencies:European Community HEALTH-F4-2007-201052Lundbeck Foundation Centre for Applied Medical Genomics in Personalized Disease Prediction, Prevention and Care (LuCamp), Metagenopolis grant ANR-11-DPBS-0001  HEALTH-F4-2012-305312Rega institute for Medical Research, KU LeuvenAgency for Innovation by Science and Technology (IWT) 267139Fund for Scientific Research Flanders (FWO)Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research) 250114EU FP7 Project TORNADO 222720European Union 600375Innovative Medicines Initiative Joint Undertaking from the European Union 115317
520 a Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids. Prevotella copri and Bacteroides vulgatus are identified as the main species driving the association between biosynthesis of BCAAs and insulin resistance, and in mice we demonstrate that P. copri can induce insulin resistance, aggravate glucose intolerance and augment circulating levels of BCAAs. Our findings suggest that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
7001 a Gudmundsdottir, Valborgu Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark4 aut
7001 a Nielsen, Henrik Bjornu Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark4 aut
7001 a Hyötyläinen, Tuulia,d 1971-u Örebro universitet,Institutionen för naturvetenskap och teknik,Turku Centre for Biotechnology, Åbo Akademi University, Turku, Finland; Turku Centre for Biotechnology, University of Turku, Turku, Finland; VTT Technical Research Centre of Finland, Espoo, Finland4 aut0 (Swepub:oru)tihn
7001 a Nielsen, Trineu Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Jensen, Benjamin A. H.u Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Forslund, Kristofferu European Molecular Biology Laboratory, Heidelberg, Germany4 aut
7001 a Hildebrand, Falku European Molecular Biology Laboratory, Heidelberg, Germany; Department of Bioscience Engineering, Vrije Universiteit Brussel, Brussels, Belgium; Center for the Biology of Disease, VIB, Leuven, Belgium4 aut
7001 a Prifti, Ediu MGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France; Institute of Cardiometabolism and Nutrition (ICAN), Paris, France4 aut
7001 a Falony, Gwenu Center for the Biology of Disease, VIB, Leuven, Belgium; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium4 aut
7001 a Le Chatelier, Emmanuelleu MGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France4 aut
7001 a Levenez, Florenceu MGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France4 aut
7001 a Dore, Joelu MGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France; Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France4 aut
7001 a Mattila, Ismou VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark4 aut
7001 a Plichta, Damian R.u Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark4 aut
7001 a Pöhö, Paiviu VTT Technical Research Centre of Finland, Espoo, Finland; Faculty of Pharmacy, University of Helsinki, Helsinki, Finland4 aut
7001 a Hellgren, Lars I.u Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark4 aut
7001 a Arumugam, Manimozhiyanu Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Sunagawa, Shinichiu European Molecular Biology Laboratory, Heidelberg, Germany; Institute of Microbiology, ETH Zurich, Zurich, Switzerland4 aut
7001 a Vieira-Silva, Sarau Center for the Biology of Disease, VIB, Leuven, Belgium; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium4 aut
7001 a Jørgensen, Torbenu Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Research Centre for Prevention and Health, Centre for Health, Capital Region, Glostrup Hospital, Glostrup, Denmark4 aut
7001 a Holm, Jacob Baku Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Trost, Kajetanu Steno Diabetes Center, Gentofte, Denmark4 aut
7001 a Kristiansen, Karstenu Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark; BGI-Shenzhen, Shenzhen, China4 aut
7001 a Brix, Susanneu Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark4 aut
7001 a Raes, Jeroenu Department of Bioscience Engineering, Vrije Universiteit Brussel, Brussels, Belgium; Center for the Biology of Disease, VIB, Leuven, Belgium; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium4 aut
7001 a Wang, Junu Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark; BGI-Shenzhen, Shenzhen, China; Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia; Macau University of Science and Technology, Taipa, China; Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China4 aut
7001 a Hansen, Torbenu Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark4 aut
7001 a Bork, Peeru European Molecular Biology Laboratory, Heidelberg, Germany; Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany; Max Delbrück Centre for Molecular Medicine, Berlin, Germany; Department of Bioinformatics, University of Wuerzburg, Würzburg, Germany4 aut
7001 a Brunak, Sørenu Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Oresic, Matej,d 1967-u Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland; VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark4 aut0 (Swepub:oru)moc
7001 a Ehrlich, S. Duskou Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark; University of Örebro, Örebro, Sweden4 aut
7001 a Pedersen, Olufu Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut
7102 a Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finlandb Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark4 org
7730 t Natured : Nature Publishing Groupg 535:7612, s. 376-381q 535:7612<376-381x 0028-0836x 1476-4687
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51849
8564 8u https://doi.org/10.1038/nature18646

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