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Induction of System...
Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN
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- Pollard, K. Michael (author)
- Scripps Research Institute, CA 92037 USA
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- Escalante, Gabriela M. (author)
- Scripps Research Institute, CA 92037 USA
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- Huang, Hua (author)
- Scripps Research Institute, CA 92037 USA
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- Haraldsson, Katarina M. (author)
- Scripps Research Institute, CA 92037 USA
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- Hultman, Per (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk patologi
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- Christy, Joseph M. (author)
- Scripps Research Institute, CA 92037 USA
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- Pawar, Rahul D. (author)
- Scripps Research Institute, CA 92037 USA
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- Mayeux, Jessica M. (author)
- Scripps Research Institute, CA 92037 USA
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- Gonzalez-Quintial, Rosana (author)
- Scripps Research Institute, CA 92037 USA
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- Baccala, Roberto (author)
- Scripps Research Institute, CA 92037 USA
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- Beutler, Bruce (author)
- University of Texas Southwestern Medical Centre Dallas, USA
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- Theofilopoulos, Argyrios N. (author)
- Scripps Research Institute, CA 92037 USA
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- Kono, Dwight H. (author)
- Scripps Research Institute, CA 92037 USA
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(creator_code:org_t)
- 2017-12-01
- 2017
- English.
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In: Journal of Immunology. - : AMER ASSOC IMMUNOLOGISTS. - 0022-1767 .- 1550-6606. ; 199:11, s. 3739-3747
- Related links:
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https://www.jimmunol...
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
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- Type I IFN and nucleic acid-sensing TLRs are both strongly implicated in the pathogenesis of lupus, with most patients expressing IFN-induced genes in peripheral blood cells and with TLRs promoting type I IFNs and autoreactive B cells. About a third of systemic lupus erythematosus patients, however, lack the IFN signature, suggesting the possibility of type I IFN-independent mechanisms. In this study, we examined the role of type I IFN and TLR trafficking and signaling in xenobiotic systemic mercury-induced autoimmunity (HgIA). Strikingly, autoantibody production in HgIA was not dependent on the type I IFN receptor even in NZB mice that require type I IFN signaling for spontaneous disease, but was dependent on the endosomal TLR transporter UNC93B1 and the endosomal proton transporter, solute carrier family 15, member 4. HgIA also required the adaptor protein-3 complex, which transports TLRs from the early endosome to the late endolysosomal compartments. Examination of TLR signaling pathways implicated the canonical NF-kappa B pathway and the proinflammatory cytokine IL-6 in autoantibody production, but not IFN regulatory factor 7. These findings identify HgIA as a novel type I IFN-independent model of systemic autoimmunity and implicate TLR-mediated NF-kappa B proinflammatory signaling from the late endocytic pathway compartments in autoantibody generation.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pollard, K. Mich ...
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Escalante, Gabri ...
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Huang, Hua
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Haraldsson, Kata ...
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Hultman, Per
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Christy, Joseph ...
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show more...
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Pawar, Rahul D.
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Mayeux, Jessica ...
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Gonzalez-Quintia ...
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Baccala, Roberto
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Beutler, Bruce
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Theofilopoulos, ...
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Kono, Dwight H.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
- Articles in the publication
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Journal of Immun ...
- By the university
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Linköping University