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  • Bertels, XanderDepartment of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands (författare)

Phenotyping asthma with airflow obstruction in middle-aged and older adults : a CADSET clinical research collaboration

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • BMJ Publishing Group Ltd,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-214066
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214066URI
  • https://doi.org/10.1136/bmjresp-2023-001760DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: The prevalence and clinical profile of asthma with airflow obstruction (AO) remain uncertain. We aimed to phenotype AO in population- and clinic-based cohorts.METHODS: This cross-sectional multicohort study included adults ≥50 years from nine CADSET cohorts with spirometry data (N=69 789). AO was defined as ever diagnosed asthma with pre-BD or post-BD FEV1/FVC <0.7 in population-based and clinic-based cohorts, respectively. Clinical characteristics and comorbidities of AO were compared with asthma without airflow obstruction (asthma-only) and chronic obstructive pulmonary disease (COPD) without asthma history (COPD-only). ORs for comorbidities adjusted for age, sex, smoking status and body mass index (BMI) were meta-analysed using a random effects model.RESULTS: The prevalence of AO was 2.1% (95% CI 2.0% to 2.2%) in population-based, 21.1% (95% CI 18.6% to 23.8%) in asthma-based and 16.9% (95% CI 15.8% to 17.9%) in COPD-based cohorts. AO patients had more often clinically relevant dyspnoea (modified Medical Research Council score ≥2) than asthma-only (+14.4 and +14.7 percentage points) and COPD-only (+24.0 and +5.0 percentage points) in population-based and clinic-based cohorts, respectively. AO patients had more often elevated blood eosinophil counts (>300 cells/µL), although only significant in population-based cohorts. Compared with asthma-only, AO patients were more often men, current smokers, with a lower BMI, had less often obesity and had more often chronic bronchitis. Compared with COPD-only, AO patients were younger, less often current smokers and had less pack-years. In the general population, AO patients had a higher risk of coronary artery disease than asthma-only and COPD-only (OR=2.09 (95% CI 1.26 to 3.47) and OR=1.89 (95% CI 1.10 to 3.24), respectively) and of depression (OR=1.41 (95% CI 1.19 to 1.67)), osteoporosis (OR=2.30 (95% CI 1.43 to 3.72)) and gastro-oesophageal reflux disease (OR=1.68 (95% CI 1.06 to 2.68)) than COPD-only, independent of age, sex, smoking status and BMI.CONCLUSIONS: AO is a relatively prevalent respiratory phenotype associated with more dyspnoea and a higher risk of coronary artery disease and elevated blood eosinophil counts in the general population compared with both asthma-only and COPD-only.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Edris, AhmedDepartment of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands (författare)
  • Garcia-Aymerich, JudithNon-Communicable Diseases and Environment Programme, ISGlobal, Barcelona, Spain; Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain (författare)
  • Faner, RosaCentro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain; Department of Biomedical Sciences, University of Barcelona, Barcelona, Spain (författare)
  • Meteran, HowramanDepartment of Respiratory Medicine, Copenhagen University Hospital-Amager and Hvidovre, Denmark; Environment, Occupation and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Aarhus, Denmark (författare)
  • Sigsgaard, TorbenEnvironment, Occupation and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Aarhus, Denmark (författare)
  • Alter, PeterDepartment of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg, Marburg, Germany (författare)
  • Vogelmeier, ClausDepartment of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg, Marburg, Germany; Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Vienna, Austria (författare)
  • Olvera, NuriaCentro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain (författare)
  • Kermani, Nazanin ZounematNational Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom (författare)
  • Agusti, AlvarCentro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain; Department of Medicine, University of Barcelona, Barcelona, Spain; Respiratory Institute, Hospital Clinic de Barcelona, Barcelona, Spain (författare)
  • Donaldson, Gavin C.National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom (författare)
  • Wedzicha, Jadwiga A.National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom (författare)
  • Brusselle, Guy G.Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands; Department of Respiratory Medicine, Erasmus MC, Rotterdam, Netherlands; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium (författare)
  • Backman, HelenaUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)heaban01 (författare)
  • Rönmark, EvaUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)evra0004 (författare)
  • Lindberg, AnneUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)anelig02 (författare)
  • Vonk, Judith M.Department of Epidemiology, University Medical Centre Groningen, Groningen, Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Centre Groningen, Groningen, Netherlands (författare)
  • Chung, Kian FanNational Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom (författare)
  • Adcock, Ian M.National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom (författare)
  • van den Berge, MaartenGroningen Research Institute for Asthma and COPD (GRIAC), University Medical Centre Groningen, Groningen, Netherlands; Department of Pulmonology, University Medical Centre Groningen, Groningen, Netherlands (författare)
  • Lahousse, LiesDepartment of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands (författare)
  • Department of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, NetherlandsNon-Communicable Diseases and Environment Programme, ISGlobal, Barcelona, Spain; Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMJ Open Respiratory Research: BMJ Publishing Group Ltd10:12052-4439

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