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  • Mints, MichaelKarolinska Institutet,Umeå universitet,Urologi och andrologi,Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel (author)

Tumour inflammation signature and expression of S100A12 and HLA class I improve survival in HPV-negative hypopharyngeal cancer

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-01-19
  • Nature Publishing Group,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-180715
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180715URI
  • https://doi.org/10.1038/s41598-020-80226-zDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147217909URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Hypopharyngeal squamous cell carcinoma (HPSCC) has a very poor prognosis. Local surgery may increase survival, but is often avoided due to significant post-op co-morbidities. Since prognostic markers are lacking, the aim was to find predictive biomarkers that identify patients whose response to oncological treatment is poor and who may benefit from primary surgery to increase survival. Pretreatment biopsies from 23 HPSCC patients, 3 human papillomavirus (HPV) positive and 20 HPV-negative, were analyzed for expression of 750 mRNAs using the Nanostring nCounter IO360 panel in relation to 3-year survival. Validation was performed through immunohistochemistry (IHC) for HLA class I and S100A12 in 74 HPV-negative HPSCC samples. Clustering identified a subset of HPV-negative HPSCC with favorable prognosis and a gene expression signature overexpressing calgranulins and immune genes, distinct from that of HPV-positive HPSCC. Enrichment analysis showed immune signaling, including the tumor inflammation signature, to be enriched in surviving patients. IHC validation confirmed high S100A12 and HLA class I expression to correlate with survival in HPV-negative HPSCC. This shows that immune activity is strongly related to survival in HPV-negative HPSCC. Enrichment of the tumor inflammation signature indicates a potential benefit of immunotherapy. Low expression of both HLA class I and S100A12 could be used to select patients for local surgery.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Landin, DavidKarolinska Institutet (author)
  • Näsman, AndersKarolinska Institutet (author)
  • Mirzaie, Leila (author)
  • Ursu, Ramona Gabriela (author)
  • Zupancic, Mark (author)
  • Marklund, LindaKarolinska Institutet (author)
  • Dalianis, TinaKarolinska Institutet (author)
  • Munck-Wikland, EvaKarolinska Institutet (author)
  • Ramqvist, TorbjörnKarolinska Institutet (author)
  • Umeå universitetUrologi och andrologi (creator_code:org_t)

Related titles

  • In:Scientific Reports: Nature Publishing Group11:12045-2322

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