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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005409naa a2200649 4500
001oai:DiVA.org:umu-172551
003SwePub
008200629s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-83239
009oai:DiVA.org:uu-421139
009oai:prod.swepub.kib.ki.se:143808235
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1725512 URI
0247 a https://doi.org/10.1111/bjh.167902 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-832392 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4211392 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1438082352 URI
040 a (SwePub)umud (SwePub)orud (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Moreno Berggren, Danielu Uppsala universitet,Hematologi4 aut0 (Swepub:uu)danmo233
2451 0a Prognostic scoring systems and comorbidities in chronic myelomonocytic leukaemia :b a nationwide population-based study
264 c 2020-06-05
264 1b John Wiley & Sons,c 2021
338 a electronic2 rdacarrier
520 a Outcomes in chronic myelomonocytic leukaemia (CMML) are highly variable and may be affected by comorbidity. Therefore, prognostic models and comorbidity indices are important tools to estimate survival and to guide clinicians in individualising treatment. In this nationwide population-based study, we assess comorbidities and for the first time validate comorbidity indices in CMML. We also compare the prognostic power of: the revised International Prognostic Scoring System (IPSS-R), CMML-specific prognostic scoring system (CPSS), MD Anderson Prognostic Scoring System (MDAPS) and Mayo score. In this cohort of 337 patients with CMML, diagnosed between 2009 and 2015, the median overall survival was 21 center dot 3 months. Autoimmune conditions were present in 25% of the patients, with polymyalgia rheumatica and Hashimoto's thyroiditis being most common. Of the tested comorbidity indices: the Charlson Comorbidity Index (CCI), Haematopoietic cell transplantation-specific Comorbidity Index (HCT-CI) and Myelodysplastic Syndrome-Specific Comorbidity Index (MDS-CI), CCI had the highest C-index (0 center dot 62) and was the only comorbidity index independently associated with survival in multivariable analyses. When comparing the prognostic power of the scoring systems, the CPSS had the highest C-index (0 center dot 69). In conclusion, using 'real-world' data we found that the CCI and CPSS have the best prognostic power and that autoimmune conditions are overrepresented in CMML.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
653 a chronic myelomonocytic leukaemia (CMML)
653 a prognostic scores
653 a comorbidity index
653 a population-based study
653 a CMML-specific prognostic scoring system (CPSS)
7001 a Kjellander, Matildau Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital and PO Hematology, Karolinska University Hospital, Stockholm, Sweden4 aut
7001 a Backlund, Ellenu Uppsala universitet,Hematologi4 aut
7001 a Engvall, Marieu Uppsala universitet,Medicinsk genetik och genomik4 aut0 (Swepub:uu)masev498
7001 a Garelius, Hegeu Section for Haematology and Coagulation, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden4 aut
7001 a Lorenz, Fryderyku Umeå universitet,Onkologi,Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden4 aut0 (Swepub:umu)frlo0008
7001 a Nilsson, Larsu Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden4 aut
7001 a Rasmussen, Bengt,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)bgrn
7001 a Lehmann, Sörenu Karolinska Institutet,Uppsala universitet,Hematologi4 aut0 (Swepub:uu)sorle534
7001 a Hellström-Lindberg, Evau Karolinska Institutet4 aut
7001 a Jädersten, Martinu Karolinska Institutet4 aut
7001 a Ungerstedt, Johannau Karolinska Institutet4 aut
7001 a Ejerblad, Elisabethu Uppsala universitet,Hematologi4 aut0 (Swepub:uu)eleje020
7102 a Uppsala universitetb Hematologi4 org
7730 t British Journal of Haematologyd : John Wiley & Sonsg 192:3, s. 474-483q 192:3<474-483x 0007-1048x 1365-2141
8564 u https://doi.org/10.1111/bjh.16790y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1448692/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.16790
8564 u https://uu.diva-portal.org/smash/get/diva2:1473530/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-172551
8564 8u https://doi.org/10.1111/bjh.16790
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-83239
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421139
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:143808235

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