WFRF:(Gabriel R. S.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 12416naa a2202917 4500 | |
| 001 | oai:DiVA.org:uu-147275 | |
| 003 | SwePub | |
| 008 | 110224s2010 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:bcb56acf-af8b-4795-9113-593c8f47c227 | |
| 009 | oai:prod.swepub.kib.ki.se:121097165 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1472752 URI |
| 024 | 7 | a https://doi.org/10.1038/nature092702 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/16779882 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1210971652 URI |
| 040 | a (SwePub)uud (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Teslovich, Tanya M.4 aut |
| 245 | 1 0 | a Biological, clinical and population relevance of 95 loci for blood lipids |
| 264 | 1 | b Springer Science and Business Media LLC,c 2010 |
| 338 | a print2 rdacarrier | |
| 520 | a Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P<5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Musunuru, Kiran4 aut |
| 700 | 1 | a Smith, Albert V.4 aut |
| 700 | 1 | a Edmondson, Andrew C.4 aut |
| 700 | 1 | a Stylianou, Ioannis M.4 aut |
| 700 | 1 | a Koseki, Masahiro4 aut |
| 700 | 1 | a Pirruccello, James P.4 aut |
| 700 | 1 | a Ripatti, Samuli4 aut |
| 700 | 1 | a Chasman, Daniel I.4 aut |
| 700 | 1 | a Willer, Cristen J.4 aut |
| 700 | 1 | a Johansen, Christopher T.4 aut |
| 700 | 1 | a Fouchier, Sigrid W.4 aut |
| 700 | 1 | a Isaacs, Aaron4 aut |
| 700 | 1 | a Peloso, Gina M.4 aut |
| 700 | 1 | a Barbalic, Maja4 aut |
| 700 | 1 | a Ricketts, Sally L.4 aut |
| 700 | 1 | a Bis, Joshua C.4 aut |
| 700 | 1 | a Aulchenko, Yurii S.4 aut |
| 700 | 1 | a Thorleifsson, Gudmar4 aut |
| 700 | 1 | a Feitosa, Mary F.4 aut |
| 700 | 1 | a Chambers, John4 aut |
| 700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
| 700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
| 700 | 1 | a Johnson, Toby4 aut |
| 700 | 1 | a Li, Xiaohui4 aut |
| 700 | 1 | a Guo, Xiuqing4 aut |
| 700 | 1 | a Li, Mingyao4 aut |
| 700 | 1 | a Cho, Yoon Shin4 aut |
| 700 | 1 | a Go, Min Jin4 aut |
| 700 | 1 | a Kim, Young Jin4 aut |
| 700 | 1 | a Lee, Jong-Young4 aut |
| 700 | 1 | a Park, Taesung4 aut |
| 700 | 1 | a Kim, Kyungau Karolinska Institutet4 aut |
| 700 | 1 | a Sim, Xueling4 aut |
| 700 | 1 | a Ong, Rick Twee-Hee4 aut |
| 700 | 1 | a Croteau-Chonka, Damien C.4 aut |
| 700 | 1 | a Lange, Leslie A.4 aut |
| 700 | 1 | a Smith, Joshua D.4 aut |
| 700 | 1 | a Song, Kijoung4 aut |
| 700 | 1 | a Zhao, Jing Hua4 aut |
| 700 | 1 | a Yuan, Xin4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Lamina, Claudia4 aut |
| 700 | 1 | a Ziegler, Andreas4 aut |
| 700 | 1 | a Zhang, Weihua4 aut |
| 700 | 1 | a Zee, Robert Y. L.4 aut |
| 700 | 1 | a Wright, Alan F.4 aut |
| 700 | 1 | a Witteman, Jacqueline C. M.4 aut |
| 700 | 1 | a Wilson, James F.4 aut |
| 700 | 1 | a Willemsen, Gonneke4 aut |
| 700 | 1 | a Wichmann, H. -Erich4 aut |
| 700 | 1 | a Whitfield, John B.4 aut |
| 700 | 1 | a Waterworth, Dawn M.4 aut |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Waeber, Gerard4 aut |
| 700 | 1 | a Vollenweider, Peter4 aut |
| 700 | 1 | a Voight, Benjamin F.4 aut |
| 700 | 1 | a Vitart, Veronique4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a Uda, Manuela4 aut |
| 700 | 1 | a Tuomilehto, Jaakko4 aut |
| 700 | 1 | a Thompson, John R.4 aut |
| 700 | 1 | a Tanaka, Toshiko4 aut |
| 700 | 1 | a Surakka, Ida4 aut |
| 700 | 1 | a Stringham, Heather M.4 aut |
| 700 | 1 | a Spector, Tim D.4 aut |
| 700 | 1 | a Soranzo, Nicole4 aut |
| 700 | 1 | a Smit, Johannes H.4 aut |
| 700 | 1 | a Sinisalo, Juha4 aut |
| 700 | 1 | a Silander, Kaisa4 aut |
| 700 | 1 | a Sijbrands, Eric J. G.4 aut |
| 700 | 1 | a Scuteri, Angelo4 aut |
| 700 | 1 | a Scott, James4 aut |
| 700 | 1 | a Schlessinger, David4 aut |
| 700 | 1 | a Sanna, Serena4 aut |
| 700 | 1 | a Salomaa, Veikko4 aut |
| 700 | 1 | a Saharinen, Juha4 aut |
| 700 | 1 | a Sabatti, Chiara4 aut |
| 700 | 1 | a Ruokonen, Aimo4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Rose, Lynda M.4 aut |
| 700 | 1 | a Roberts, Robert4 aut |
| 700 | 1 | a Rieder, Mark4 aut |
| 700 | 1 | a Psaty, Bruce M.4 aut |
| 700 | 1 | a Pramstaller, Peter P.4 aut |
| 700 | 1 | a Pichler, Irene4 aut |
| 700 | 1 | a Perola, Markus4 aut |
| 700 | 1 | a Penninx, Brenda W. J. H.4 aut |
| 700 | 1 | a Pedersen, Nancy L.u Karolinska Institutet4 aut |
| 700 | 1 | a Pattaro, Cristian4 aut |
| 700 | 1 | a Parker, Alex N.4 aut |
| 700 | 1 | a Pare, Guillaume4 aut |
| 700 | 1 | a Oostra, Ben A.4 aut |
| 700 | 1 | a O'Donnell, Christopher J.4 aut |
| 700 | 1 | a Nieminen, Markku S.4 aut |
| 700 | 1 | a Nickerson, Deborah A.4 aut |
| 700 | 1 | a Montgomery, Grant W.4 aut |
| 700 | 1 | a Meitinger, Thomas4 aut |
| 700 | 1 | a McPherson, Ruth4 aut |
| 700 | 1 | a McCarthy, Mark I.4 aut |
| 700 | 1 | a McArdle, Wendy4 aut |
| 700 | 1 | a Masson, David4 aut |
| 700 | 1 | a Martin, Nicholas G.4 aut |
| 700 | 1 | a Marroni, Fabio4 aut |
| 700 | 1 | a Mangino, Massimo4 aut |
| 700 | 1 | a Magnusson, Patrik K. E.4 aut |
| 700 | 1 | a Lucas, Gavin4 aut |
| 700 | 1 | a Luben, Robert4 aut |
| 700 | 1 | a Loos, Ruth J. F.4 aut |
| 700 | 1 | a Lokki, Marja-Liisa4 aut |
| 700 | 1 | a Lettre, Guillaume4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Launer, Lenore J.4 aut |
| 700 | 1 | a Lakatta, Edward G.4 aut |
| 700 | 1 | a Laaksonen, Reijo4 aut |
| 700 | 1 | a Kyvik, Kirsten O.4 aut |
| 700 | 1 | a Kronenberg, Florian4 aut |
| 700 | 1 | a Koenig, Inke R.4 aut |
| 700 | 1 | a Khaw, Kay-Tee4 aut |
| 700 | 1 | a Kaprio, Jaakko4 aut |
| 700 | 1 | a Kaplan, Lee M.4 aut |
| 700 | 1 | a Johansson, Åsau Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)asjoh108 |
| 700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
| 700 | 1 | a Janssens, A. Cecile J. W.4 aut |
| 700 | 1 | a Ingelsson, Eriku Karolinska Institutet4 aut |
| 700 | 1 | a Igi, Wilmaru Uppsala universitet,Institutionen för genetik och patologi4 aut |
| 700 | 1 | a Hovingh, G. Kees4 aut |
| 700 | 1 | a Hottenga, Jouke-Jan4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Hicks, Andrew A.4 aut |
| 700 | 1 | a Hengstenberg, Christian4 aut |
| 700 | 1 | a Heid, Iris M.4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Havulinna, Aki S.4 aut |
| 700 | 1 | a Hastie, Nicholas D.4 aut |
| 700 | 1 | a Harris, Tamara B.4 aut |
| 700 | 1 | a Haritunians, Talin4 aut |
| 700 | 1 | a Hall, Alistair S.4 aut |
| 700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)ulfgyll |
| 700 | 1 | a Guiducci, Candace4 aut |
| 700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
| 700 | 1 | a Gonzalez, Elena4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Freimer, Nelson B.4 aut |
| 700 | 1 | a Ferrucci, Luigi4 aut |
| 700 | 1 | a Erdmann, Jeanette4 aut |
| 700 | 1 | a Elliott, Paul4 aut |
| 700 | 1 | a Ejebe, Kenechi G.4 aut |
| 700 | 1 | a Doering, Angela4 aut |
| 700 | 1 | a Dominiczak, Anna F.4 aut |
| 700 | 1 | a Demissie, Serkalem4 aut |
| 700 | 1 | a Deloukas, Panagiotis4 aut |
| 700 | 1 | a de Geus, Eco J. C.4 aut |
| 700 | 1 | a de Faire, Ulfu Karolinska Institutet4 aut |
| 700 | 1 | a Crawford, Gabriel4 aut |
| 700 | 1 | a Collins, Francis S.4 aut |
| 700 | 1 | a Chen, Yii-der I.4 aut |
| 700 | 1 | a Caulfield, Mark J.4 aut |
| 700 | 1 | a Campbell, Harry4 aut |
| 700 | 1 | a Burtt, Noel P.4 aut |
| 700 | 1 | a Bonnycastle, Lori L.4 aut |
| 700 | 1 | a Boomsma, Dorret I.4 aut |
| 700 | 1 | a Boekholdt, S. Matthijs4 aut |
| 700 | 1 | a Bergman, Richard N.4 aut |
| 700 | 1 | a Barroso, Ines4 aut |
| 700 | 1 | a Bandinelli, Stefania4 aut |
| 700 | 1 | a Ballantyne, Christie M.4 aut |
| 700 | 1 | a Assimes, Themistocles L.4 aut |
| 700 | 1 | a Quertermous, Thomas4 aut |
| 700 | 1 | a Altshuler, David4 aut |
| 700 | 1 | a Seielstad, Mark4 aut |
| 700 | 1 | a Wong, Tien Y.4 aut |
| 700 | 1 | a Tai, E-Shyong4 aut |
| 700 | 1 | a Feranil, Alan B.4 aut |
| 700 | 1 | a Kuzawa, Christopher W.4 aut |
| 700 | 1 | a Adair, Linda S.4 aut |
| 700 | 1 | a Taylor, Herman A., Jr.4 aut |
| 700 | 1 | a Borecki, Ingrid B.4 aut |
| 700 | 1 | a Gabriel, Stacey B.4 aut |
| 700 | 1 | a Wilson, James G.4 aut |
| 700 | 1 | a Holm, Hilma4 aut |
| 700 | 1 | a Thorsteinsdottir, Unnur4 aut |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Krauss, Ronald M.4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a Ordovas, Jose M.4 aut |
| 700 | 1 | a Munroe, Patricia B.4 aut |
| 700 | 1 | a Kooner, Jaspal S.4 aut |
| 700 | 1 | a Tall, Alan R.4 aut |
| 700 | 1 | a Hegele, Robert A.4 aut |
| 700 | 1 | a Kastelein, John J. P.4 aut |
| 700 | 1 | a Schadt, Eric E.4 aut |
| 700 | 1 | a Rotter, Jerome I.4 aut |
| 700 | 1 | a Boerwinkle, Eric4 aut |
| 700 | 1 | a Strachan, David P.4 aut |
| 700 | 1 | a Mooser, Vincent4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a Reilly, Muredach P.4 aut |
| 700 | 1 | a Samani, Nilesh J.4 aut |
| 700 | 1 | a Schunkert, Heribert4 aut |
| 700 | 1 | a Cupples, L. Adrienne4 aut |
| 700 | 1 | a Sandhu, Manjinder S.4 aut |
| 700 | 1 | a Ridker, Paul M.4 aut |
| 700 | 1 | a Rader, Daniel J.4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Peltonen, Leena4 aut |
| 700 | 1 | a Abecasis, Goncalo R.4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Kathiresan, Sekar4 aut |
| 710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Natured : Springer Science and Business Media LLCg 466:7307, s. 707-713q 466:7307<707-713x 0028-0836x 1476-4687 |
| 856 | 4 | u https://europepmc.org/articles/pmc3039276?pdf=render |
| 856 | 4 | u http://dx.doi.org/10.1038/nature09270y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-147275 |
| 856 | 4 8 | u https://doi.org/10.1038/nature09270 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1677988 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:121097165 |
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