Sökning: WFRF:(Hampel J) > Prevalence of the a...
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000 | 11053naa a2201453 4500 | |
001 | oai:DiVA.org:liu-150288 | |
003 | SwePub | |
008 | 180817s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1502882 URI |
024 | 7 | a https://doi.org/10.1016/j.jalz.2018.02.0092 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mattsson, Niklasu Lund Univ, Sweden4 aut |
245 | 1 0 | a Prevalence of the apolipoprotein E epsilon 4 allele in amyloid beta positive subjects across the spectrum of Alzheimers disease |
264 | c 2018-03-27 | |
264 | 1 | b ELSEVIER SCIENCE INC,c 2018 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies|AXA Research Fund; Fondation Universite Pierre et Marie Curie; "Fondation pour la Recherche sur Alzheimer", Paris, France; program "Investissements davenir" [ANR-10-IAIHU-06]; National Institutes of Health [P50 AG005133, RF1 AG025516, PO1 AG025204]; Marie Curie FP7 International Outgoing Fellowship [628812]; Instituto de Salud Carlos III (Fondo de InvestigaciOn Sanitario) [PI08/0139, PI12/02288, PI16/01652]; NIH/NIA [RF1 AG057570, AG035137, AG032554, AG022374, AG13616, AG12101, AG08051, NIH-HLB HL111724]; Instituto de Salud Carlos III (CIBERNED program) | |
520 | a Introduction: Apolipoprotein E (APOE) epsilon 4 is the major genetic risk factor for Alzheimers disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid beta(A beta) pathology. Methods: We included 3451 A beta+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE epsilon 4 prevalence in relation to age, sex, education, and geographical location. Results: The APOE epsilon 4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in A beta+ cognitively normal and A beta+ mild cognitive impairment (P amp;lt;.05) but not in A beta+ AD dementia (P =.66). The prevalence was highest in Northern Europe but did not vary by sex or education. Discussion: The APOE E4 prevalence in AD was higher than that in previous studies, which did not require presence of A beta pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location. (C) 2018 the Alzheimers Association. Published by Elsevier Inc. All rights reserved. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng |
653 | a APOE; Prevalence; Amyloid; PET; CSF; Alzheimers disease; Mild cognitive impairment; Subjective cognitive decline; Age; Sex; Education; Geographical location | |
700 | 1 | a Groot, Colinu Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut |
700 | 1 | a Jansen, Willemijn J.u Maastricht Univ, Netherlands4 aut |
700 | 1 | a Landau, Susan M.u Univ Calif Berkeley, CA 94720 USA4 aut |
700 | 1 | a Villemagne, Victor L.u Austin Hlth, Australia; Austin Hlth, Australia4 aut |
700 | 1 | a Engelborghs, Sebastiaanu Univ Antwerp, Belgium4 aut |
700 | 1 | a Mintun, Mark M.u Avid Radiopharmaceut, PA USA4 aut |
700 | 1 | a Lleo, Albertou Hosp Santa Creu and Sant Pau, Spain4 aut |
700 | 1 | a Molinuevo, Jose Luisu Clin Univ Hosp, Spain4 aut |
700 | 1 | a Jagust, William J.u Univ Calif Berkeley, CA 94720 USA4 aut |
700 | 1 | a Frisoni, Giovanni B.u Univ Hosp, Switzerland; Univ Hosp, Switzerland; Univ Geneva, Switzerland; IRCCS, Italy4 aut |
700 | 1 | a Ivanoiu, Adrianu Clin Univ Hosp, Spain; Catholic Univ Louvain, Belgium; Catholic Univ Louvain, Belgium4 aut |
700 | 1 | a Chetelat, Gaelu Univ Caen Normandie, France4 aut |
700 | 1 | a de Oliveira, Catarina Resendeu CHU Coimbra, Portugal4 aut |
700 | 1 | a Rodrigue, Karen M.u Univ Texas Dallas, TX USA4 aut |
700 | 1 | a Kornhuber, Johannesu Friedrich Alexander Univ Erlangen Nuremberg, Germany4 aut |
700 | 1 | a Wallin, Andersu Univ Gothenburg, Sweden4 aut |
700 | 1 | a Klimkowicz-Mrowiec, Aleksandrau Jagiellonian Univ, Poland4 aut |
700 | 1 | a Kandimalla, Rameshu Postgrad Inst Med Educ and Res PGIMER, India4 aut |
700 | 1 | a Popp, Juliusu Univ Hosp Lausanne, Switzerland4 aut |
700 | 1 | a Aalten, Pauline P.u Maastricht Univ, Netherlands4 aut |
700 | 1 | a Aarsland, Dagu Stavanger Univ Hosp, Norway4 aut |
700 | 1 | a Alcolea, Danielu Hosp Santa Creu and Sant Pau, Spain4 aut |
700 | 1 | a Almdahl, Ina S.u Akershus Univ Hosp, Norway4 aut |
700 | 1 | a Baldeiras, Inesu CHU Coimbra, Portugal4 aut |
700 | 1 | a van Buchem, Mark A.u Leiden Univ, Netherlands4 aut |
700 | 1 | a Cavedo, Enricau IRCCS, Italy; Univ Pierre and Marie Curie UPMC Paris 06, France4 aut |
700 | 1 | a Chen, Keweiu Banner Alzheimers Inst, AZ USA4 aut |
700 | 1 | a Cohen, Ann D.u Univ Pittsburgh, PA USA4 aut |
700 | 1 | a Foerster, Stefanu Tech Univ Munich, Germany4 aut |
700 | 1 | a Fortea, Juanu Hosp Santa Creu and Sant Pau, Spain4 aut |
700 | 1 | a Frederiksen, Kristian S.u Univ Copenhagen, Denmark4 aut |
700 | 1 | a Freund-Levi, Yvonneu Karolinska Univ, Sweden4 aut |
700 | 1 | a Gill, Kiran Dipu Postgrad Inst Med Educ and Res PGIMER, India4 aut |
700 | 1 | a Gkatzima, Olymbiau Aristotle Univ Thessaloniki, Greece4 aut |
700 | 1 | a Grimmer, Timou Techn Univ Munchen, Germany4 aut |
700 | 1 | a Hampel, Haraldu Univ Pierre and Marie Curie UPMC Paris 06, France; Ludwig Maximilians Univ Munchen, Germany; Ludwig Maximilians Univ Munchen, Germany4 aut |
700 | 1 | a Herukka, Sanna-Kaisau Univ Eastern Finland, Finland; Kuopio Univ Hosp, Finland4 aut |
700 | 1 | a Johannsen, Peteru Rigshosp, Denmark4 aut |
700 | 1 | a van Laere, Koenu Katholieke Univ Leuven, Belgium4 aut |
700 | 1 | a de Leon, Mony J.u NYU, NY USA4 aut |
700 | 1 | a Maier, Wolfgangu Univ Bonn, Germany4 aut |
700 | 1 | a Marcusson, Janu Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Medicinska och geriatriska akutkliniken4 aut0 (Swepub:liu)janma25 |
700 | 1 | a Meulenbroek, Olgau Radboud Univ Nijmegen, Netherlands4 aut |
700 | 1 | a Mollergard, Hanne M.u Akershus Univ Hosp, Norway4 aut |
700 | 1 | a Morris, John C.u Washington Univ, MO 63110 USA4 aut |
700 | 1 | a Mroczko, Barbarau Med Univ Bialystok, Poland4 aut |
700 | 1 | a Nordlund, Artou Univ Gothenburg, Sweden4 aut |
700 | 1 | a Prabhakar, Sudeshu Postgrad Inst Med Educ and Res PGIMER, India4 aut |
700 | 1 | a Peters, Oliveru German Ctr Neurodegenerat Dis DZNE, Germany4 aut |
700 | 1 | a Rami, Lorenau Clin Univ Hosp, Spain4 aut |
700 | 1 | a Rodriguez-Rodriguez, Eloyu Univ Hosp Marques Valdecilla, Spain4 aut |
700 | 1 | a Roe, Catherine M.u Washington Univ, MO 63110 USA4 aut |
700 | 1 | a Ruther, Eckartu Georg August Univ, Germany4 aut |
700 | 1 | a Santana, Isabelu CHU Coimbra, Portugal4 aut |
700 | 1 | a Schroder, Johannesu Heidelberg Univ, Germany4 aut |
700 | 1 | a Seo, Sang W.u Sungkyunkwan Univ, South Korea4 aut |
700 | 1 | a Soininen, Hilkkau Univ Eastern Finland, Finland; Kuopio Univ Hosp, Finland4 aut |
700 | 1 | a Spiru, Luizau Carol Davila Univ Med and Pharm, Romania4 aut |
700 | 1 | a Stomrud, Eriku Lund Univ, Sweden4 aut |
700 | 1 | a Struyfs, Hanneu Univ Antwerp, Belgium4 aut |
700 | 1 | a Teunissen, Charlotte E.u Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut |
700 | 1 | a Verhey, Frans R. J.u Maastricht Univ, Netherlands4 aut |
700 | 1 | a Vos, Stephanie J. B.u Maastricht Univ, Netherlands4 aut |
700 | 1 | a van Doorn, Linda J. C. van Waalwijku Radboud Univ Nijmegen, Netherlands; Radboud Univ Nijmegen, Netherlands4 aut |
700 | 1 | a Waldemar, Gunhildu Univ Copenhagen, Denmark4 aut |
700 | 1 | a Wallin, Asa K.u Lund Univ, Sweden4 aut |
700 | 1 | a Wiltfang, Jensu Georg August Univ, Germany; Georg August Univ, Germany4 aut |
700 | 1 | a Vandenberghe, Riku Katholieke Univ Leuven, Belgium; Katholieke Univ Leuven, Belgium4 aut |
700 | 1 | a Brooks, David J.u Imperial Coll London, England4 aut |
700 | 1 | a Fladby, Tormodu Akershus Univ Hosp, Norway4 aut |
700 | 1 | a Rowe, Christopher C.u Austin Hlth, Australia; Austin Hlth, Australia4 aut |
700 | 1 | a Drzezga, Alexanderu Univ Cologne, Germany4 aut |
700 | 1 | a Verbeek, Marcel M.u Radboud Univ Nijmegen, Netherlands; Radboud Univ Nijmegen, Netherlands4 aut |
700 | 1 | a Sarazin, Marieu Sorbonne Paris Cite, France4 aut |
700 | 1 | a Wolk, David A.u Univ Penn, PA 19104 USA4 aut |
700 | 1 | a Fleisher, Adam S.u Banner Alzheimers Inst, AZ USA; Eli Lilly, IN USA; Univ Calif San Diego, CA 92103 USA4 aut |
700 | 1 | a Klunk, William E.u Univ Pittsburgh, PA USA4 aut |
700 | 1 | a Na, Duk L.u Sungkyunkwan Univ, South Korea4 aut |
700 | 1 | a Sanchez-Juan, Pascualu Univ Hosp Marques Valdecilla, Spain4 aut |
700 | 1 | a Lee, Dong Youngu Seoul Natl Univ, South Korea4 aut |
700 | 1 | a Nordberg, Agnetau Karolinska Univ Hosp, Sweden4 aut |
700 | 1 | a Tsolaki, Magdau Aristotle Univ Thessaloniki, Greece4 aut |
700 | 1 | a Camus, Vincentu Univ Francois Rabelais Tours, France4 aut |
700 | 1 | a Rinne, Juha O.u Univ Turku, Finland; Univ Turku, Finland; Turku Univ Hosp, Finland4 aut |
700 | 1 | a Fagan, Anne M.u Washington Univ, MO 63110 USA4 aut |
700 | 1 | a Zetterberg, Henriku UCL, England; UK Dementia Res Inst, England; Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden4 aut |
700 | 1 | a Blennow, Kaju Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden4 aut |
700 | 1 | a Rabinovici, Gil D.u Univ Calif San Francisco, CA 94143 USA4 aut |
700 | 1 | a Hansson, Oskaru Lund Univ, Sweden4 aut |
700 | 1 | a van Berckel, Bart N. M.u Vrije Univ Amsterdam, Netherlands4 aut |
700 | 1 | a van der Flier, Wiesje M.u Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut |
700 | 1 | a Scheltens, Philipu Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut |
700 | 1 | a Visser, Pieter Jelleu Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands; Maastricht Univ, Netherlands4 aut |
700 | 1 | a Ossenkoppele, Riku Lund Univ, Sweden; Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 aut |
710 | 2 | a Lund Univ, Swedenb Vrije Univ Amsterdam, Netherlands; Vrije Univ Amsterdam, Netherlands4 org |
773 | 0 | t Alzheimer's & Dementiad : ELSEVIER SCIENCE INCg 14:7, s. 913-924q 14:7<913-924x 1552-5260x 1552-5279 |
856 | 4 | u https://lirias.kuleuven.be/bitstream/123456789/621579/1/1-s2.0-S1552526018300633-main.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150288 |
856 | 4 8 | u https://doi.org/10.1016/j.jalz.2018.02.009 |
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