SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Harris Robert A)
 

Sökning: WFRF:(Harris Robert A) > (2020-2024) > Altered perivascula...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008248naa a2200817 4500
001oai:DiVA.org:umu-182762
003SwePub
008210511s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:kth-295441
009oai:prod.swepub.kib.ki.se:146460728
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1827622 URI
0247 a https://doi.org/10.1038/s41591-021-01295-92 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2954412 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1464607282 URI
040 a (SwePub)umud (SwePub)kthd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Månberg, Anna,d 1985-u KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik4 aut0 (Swepub:kth)u1g5roxd
2451 0a Altered perivascular fibroblast activity precedes ALS disease onset
264 c 2021-04-15
264 1b Nature Publishing Group,c 2021
338 a print2 rdacarrier
500 a Publisher Correction:Månberg, A., Skene, N., Sanders, F. et al. Publisher Correction: Altered perivascular fibroblast activity precedes ALS disease onset. Nat Med 27, 1308 (2021). DOI: 10.1038/s41591-021-01414-6
500 a QC 20210621
520 a Apart from well-defined factors in neuronal cells1, only a few reports consider that the variability of sporadic amyotrophic lateral sclerosis (ALS) progression can depend on less-defined contributions from glia2,3 and blood vessels4. In this study we use an expression-weighted cell-type enrichment method to infer cell activity in spinal cord samples from patients with sporadic ALS and mouse models of this disease. Here we report that patients with sporadic ALS present cell activity patterns consistent with two mouse models in which enrichments of vascular cell genes preceded microglial response. Notably, during the presymptomatic stage, perivascular fibroblast cells showed the strongest gene enrichments, and their marker proteins SPP1 and COL6A1 accumulated in enlarged perivascular spaces in patients with sporadic ALS. Moreover, in plasma of 574 patients with ALS from four independent cohorts, increased levels of SPP1 at disease diagnosis repeatedly predicted shorter survival with stronger effect than the established risk factors of bulbar onset or neurofilament levels in cerebrospinal fluid. We propose that the activity of the recently discovered perivascular fibroblast can predict survival of patients with ALS and provide a new conceptual framework to re-evaluate definitions of ALS etiology.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
7001 a Skene, Nathanu Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden; Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, United Kingdom; United Kingdom Dementia Research Institute, London, United Kingdom4 aut
7001 a Sanders, Folkertu Department of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden4 aut
7001 a Trusohamn, Martau Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden4 aut
7001 a Remnestål, Juliau KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u13wztpi
7001 a Szczepińska, Annau Karolinska Institutet4 aut
7001 a Aksoylu, Inci Sevvalu Karolinska Institutet4 aut
7001 a Lönnerberg, Peteru Karolinska Institutet4 aut
7001 a Ebarasi, Lwakiu Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden4 aut
7001 a Wouters, Stefanu Department of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden4 aut
7001 a Lehmann, Manuelau Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)4 aut0 (Swepub:umu)male0080
7001 a Olofsson, Jennieu KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik4 aut0 (Swepub:kth)u1q8hz5k
7001 a von Gohren Antequera, Intiu Department of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden4 aut
7001 a Domaniku, Aylinu Department of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden4 aut
7001 a De Schaepdryver, Maximu Laboratory for Neurobiomarker Research, Department of Neurology, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium4 aut
7001 a De Vocht, Jokeu Neurology Department and Center for Brain & Disease Research, KU Leuven, VIB, Leuven, Belgium4 aut
7001 a Poesen, Koenu Laboratory for Neurobiomarker Research, Department of Neurology, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium; Laboratory Medicine, UZ Leuven (University Hospital Leuven), Leuven, Belgium4 aut
7001 a Uhlén, Mathiasu KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.4 aut0 (Swepub:kth)u1dulvmw
7001 a Anink, Jasperu Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands4 aut
7001 a Mijnsbergen, Carolineu Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands4 aut
7001 a Vergunst-Bosch, Hermienekeu UMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, Netherlands4 aut
7001 a Hübers, Annemarieu University of Ulm, Neurology Clinic, Ulm, Germany; Division of Neurology, Geneva University Hospital, Geneva, Switzerland4 aut
7001 a Kläppe, Ulfu Karolinska Institutet4 aut
7001 a Rodriguez-Vieitez, Elenau Karolinska Institutet4 aut
7001 a Gilthorpe, Jonathan D.u Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)4 aut0 (Swepub:umu)jogi0002
7001 a Hedlund, Evau Karolinska Institutet4 aut
7001 a Harris, Robert A.u Karolinska Institutet4 aut
7001 a Aronica, Eleonorau Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands4 aut
7001 a Van Damme, Philipu Neurology Department and Center for Brain & Disease Research, KU Leuven, VIB, Leuven, Belgium4 aut
7001 a Ludolph, Albertu University of Ulm, Neurology Clinic, Ulm, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Ulm, Bonn, Germany4 aut
7001 a Veldink, Janu UMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, Netherlands4 aut
7001 a Ingre, Carolineu Karolinska Institutet4 aut
7001 a Nilsson, Peteru KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik4 aut0 (Swepub:kth)u1ws88sk
7001 a Lewandowski, Sebastianu KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Department of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden4 aut0 (Swepub:kth)u1d4y8tu
7102 a KTHb Science for Life Laboratory, SciLifeLab4 org
7730 t Nature Medicined : Nature Publishing Groupg 27:4, s. 640-646q 27:4<640-646x 1078-8956x 1546-170X
8564 u http://spiral.imperial.ac.uk/bitstream/10044/1/89868/2/output.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-182762
8564 8u https://doi.org/10.1038/s41591-021-01295-9
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-295441
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:146460728

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy