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Trisomy 8 in pediat...
Trisomy 8 in pediatric acute myeloid leukemia : A NOPHO-AML study
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- Laursen, Anne Cathrine Lund (författare)
- Aarhus Univ Hosp, Dept Pediat, Aarhus, Denmark.
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- Sandahl, Julie Damgaard (författare)
- Aarhus Univ Hosp, Dept Pediat, Aarhus, Denmark.
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- Kjeldsen, Eigil (författare)
- Aarhus Univ Hosp, Dept Hematol, Canc Cytogenet Lab, Aarhus, Denmark.
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- Abrahamsson, Jonas, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Asdahl, Peter (författare)
- Aarhus Univ Hosp, Dept Pediat, Aarhus, Denmark.
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- Ha, Shau-Yin (författare)
- Queen Mary Hosp, Dept Pediat, Hong Kong, Hong Kong, Peoples R China.;HKPHOSG, Hong Kong, Hong Kong, Peoples R China.
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- Heldrup, Jesper (författare)
- Univ Hosp, Dept Pediat, Lund, Sweden.
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- Jahnukainen, Kirsi (författare)
- Univ Helsinki, Childrens Hosp, Cent Hosp, Helsinki, Finland.
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- Jonsson, Olafur G. (författare)
- Landspitalinn, Dept Pediat, Reykjavik, Iceland.
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- Lausen, Birgitte (författare)
- Univ Copenhagen, Dept Pediat & Adolescent Med, Rigshosp, Copenhagen, Denmark.
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- Palle, Josefine (författare)
- Uppsala universitet,Pediatrik
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- Zeller, Bernward (författare)
- Oslo Univ Hosp, Dept Pediat Med, Oslo, Norway.
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- Forestier, Erik (författare)
- Umea Univ Hosp, Dept Biosci, Clin Genet, Umea, Sweden.,Department of Medical Biosciences, Clinical Genetics, Umeå University Hospital, Umeå, Sweden
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- Hasle, Henrik (författare)
- Aarhus Univ Hosp, Dept Pediat, Aarhus, Denmark.
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Aarhus Univ Hosp, Dept Pediat, Aarhus, Denmark Aarhus Univ Hosp, Dept Hematol, Canc Cytogenet Lab, Aarhus, Denmark. (creator_code:org_t)
- 2016-06-23
- 2016
- Engelska.
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Ingår i: Genes, Chromosomes and Cancer. - : Wiley. - 1045-2257 .- 1098-2264. ; 55:9, s. 719-726
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Trisomy 8 (+8) is a common cytogenetic aberration in acute myeloid leukemia (AML); however, the impact of +8 in pediatric AML is largely unknown. We retrospectively investigated 609 patients from the NOPHO-AML database to determine the clinical and cytogenetic characteristics of +8 in pediatric AML and to investigate its prognostic impact. Complete cytogenetic data were available in 596 patients (98%) aged 0-18 years, diagnosed from 1993 to 2012, and treated according to the NOPHO-AML 1993 and 2004 protocols in the Nordic countries and Hong Kong. We identified 86 patients (14%) with +8. Trisomy 8 was combined with other cytogenetic aberrations in 68 patients (11%) (+8 other) and in 18 patients (3%), it was the sole abnormality (+8 alone). Trisomy 8 was associated with FAB M5 (36%) but otherwise clinically comparable with non-trisomy 8 patients. Trisomy 8 was favorable in patients of young age and with t(9;11). Trisomy 8 alone was associated with older age (median age 10.1 years), FAB M2 (33%), and FLT3-ITD mutations (58%). The 5-year event-free survival for patients with +8 alone was 50% and 5-year overall survival was 75%. In conclusion, +8 is one of the most common cytogenetic aberrations in pediatric AML. Trisomy 8 positive AML is a heterogeneous group and the majority of cases have additional cytogenetic aberrations. Patients with +8 alone differed from patients with +8 other and were associated with older age, FAB M2, and FLT3-ITD aberrations. There were no differences in survival despite the more frequent occurrence of FLT3-ITD in +8 alone.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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Laursen, Anne Ca ...
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Sandahl, Julie D ...
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Kjeldsen, Eigil
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Abrahamsson, Jon ...
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Asdahl, Peter
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Ha, Shau-Yin
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Heldrup, Jesper
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Jahnukainen, Kir ...
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Jonsson, Olafur ...
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Lausen, Birgitte
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Palle, Josefine
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Zeller, Bernward
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Forestier, Erik
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Hasle, Henrik
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