Extractable organofluorine analysis: A way to screen for elevated per- and polyfluoroalkyl substance contamination in humans?

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Kärrman Anna) > Extractable organof...

Extractable organofluorine analysis: A way to screen for elevated per- and polyfluoroalkyl substance contamination in humans?

Aro, Rudolf, 1992- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment (MTM) Research Centre

Eriksson, Ulrika, 1972- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment (MTM) Research Centre

Kärrman, Anna, 1975- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment (MTM) Research Centre

visa fler...

Jakobsson, Kristina (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden

Yeung, Leo W. Y., 1981- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment (MTM) Research Centre

visa färre...

(creator_code:org_t)

Elsevier BV, 2022
2022
Engelska.
Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 159

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://doi.org/10.1...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

The ubiquitous occurrence of a few per- and polyfluoroalkyl substances (PFAS) in humans and the environment has been previously reported. However, the number of PFAS humans and the environment are potentially exposed to is much higher, making it difficult to investigate every sample in detail. More importantly, recent studies have shown an increasing fraction of potentially unknown PFAS in human samples. A screening tool for identifying samples of concern that may contain high PFAS levels, to be studied more thoroughly, is needed. This study presents a simplified workflow to detect elevated PFAS levels using extractable organofluorine (EOF) analysis. A fluorine mass balance analysis on samples with high EOF, targeting 63 PFAS, can then confirm the PFAS contamination. Whole blood samples from a cohort of individuals with historical drinking water contamination from firefighting foams (n = 20) in Ronneby (Sweden) and a control group (n = 9) with background exposure were used as a case study. The average EOF concentration in the Ronneby group was 234 ng/ mL F (<107-592 ng/mL F) vs 24.8 ng/mL F (17.6-37.8 ng/mL F) in the control group. The large difference (statistically significant, p < 0.05) in the EOF levels between the exposed and control groups would have made it possible to identify samples with high PFAS exposure only using EOF data. This was confirmed by target analysis, which found an average n-ary sumation PFAS concentration of 346 ng/mL in the exposed group and 7.9 ng/mL in the control group. The limit of quantification for EOF analysis (up to 107 ng/mL F using 0.5 mL whole blood) did not allow for the detection of PFAS levels in low or sub parts per billion (ng/mL) concentrations, but the results indicate that EOF analysis is a suitable screening method sensitive enough to detect elevated/significant/exposure above background levels by known or unknown PFAS.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)

Nyckelord

Per-and polyfluoroalkyl substances (PFAS)
Organofluorine mass balance
analysis
Extractable organofluorine (EOF)
Whole blood
Combustion ion
chromatography (CIC)
perfluorooctane sulfonate pfos
tandem mass-spectrometry
perfluoroalkyl
substances
perfluorinated acids
human serum
chromatography
fluorine
surfactants
persistence
precursors
Environmental Sciences & Ecology
Combustion ion chromatography (CIC)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Environment International (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Aro, Rudolf, 199 ...; Eriksson, Ulrika ...; Kärrman, Anna, 1 ...; Jakobsson, Krist ...; Yeung, Leo W. Y. ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Annan klinisk me ...

NATURVETENSKAP: NATURVETENSKAP; och Geovetenskap och ...; och Miljövetenskap

Artiklar i publikationen: Environment Inte ...

Av lärosätet: Göteborgs universitet; Örebro universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se