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Three polymethoxyfl...
Three polymethoxyflavones from the peel of Citrus reticulata "Chachi" inhibits oxidized low-density lipoprotein-induced macrophage-derived foam cell formation
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- Liang, Pu-Lin (författare)
- Second Clin Coll Guangzhou Univ Chinese Med, Key Lab Qual Evaluat Chinese Med Guangdong Prov Me, Guangzhou, Peoples R China.
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- Liang, Qian-Wen (författare)
- Second Clin Coll Guangzhou Univ Chinese Med, Key Lab Qual Evaluat Chinese Med Guangdong Prov Me, Guangzhou, Peoples R China.
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- He, Pei-Wen (författare)
- Second Clin Coll Guangzhou Univ Chinese Med, Key Lab Qual Evaluat Chinese Med Guangdong Prov Me, Guangzhou, Peoples R China.
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- Chen, Xue-Lian (författare)
- Second Clin Coll Guangzhou Univ Chinese Med, Key Lab Qual Evaluat Chinese Med Guangdong Prov Me, Guangzhou, Peoples R China.
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- Xu, Ya (författare)
- Second Clin Coll Guangzhou Univ Chinese Med, Key Lab Qual Evaluat Chinese Med Guangdong Prov Me, Guangzhou, Peoples R China.
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- Tu, Hai-Sheng (författare)
- Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou, Peoples R China.
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- Zhang, Liang (författare)
- Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, Hefei, Peoples R China.
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- Qiu, Xiao-Hui (författare)
- Second Clin Coll Guangzhou Univ Chinese Med, Key Lab Qual Evaluat Chinese Med Guangdong Prov Me, Guangzhou, Peoples R China.;Guangdong Prov Hosp Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Med, Guangzhou, Peoples R China.
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- Zhang, Jing (författare)
- Second Clin Coll Guangzhou Univ Chinese Med, Key Lab Qual Evaluat Chinese Med Guangdong Prov Me, Guangzhou, Peoples R China.
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- Huang, Zhi-Hai (författare)
- Second Clin Coll Guangzhou Univ Chinese Med, Key Lab Qual Evaluat Chinese Med Guangdong Prov Me, Guangzhou, Peoples R China.
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- Xu, Wen (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Second Clin Coll Guangzhou Univ Chinese Med, Key Lab Qual Evaluat Chinese Med Guangdong Prov Me, Guangzhou, Peoples R China.
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Second Clin Coll Guangzhou Univ Chinese Med, Key Lab Qual Evaluat Chinese Med Guangdong Prov Me, Guangzhou, Peoples R China Guangdong Pharmaceut Univ, Sch Tradit Chinese Med, Guangzhou, Peoples R China. (creator_code:org_t)
- 2022-07-28
- 2022
- Engelska.
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Ingår i: Frontiers in Cardiovascular Medicine. - : Frontiers Media S.A.. - 2297-055X. ; 9
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Foam cell formation is the hallmark of the development and progression of atherosclerosis. The aim of this study was to investigate the regulatory effects of three polymethoxyflavones (PMFs), namely, tangeretin (TAN), 5,6,7,3 ',4 ',5 '-hexamethoxyflavone (HxMF), and 3,5,6,7,8,3 ',4 '-heptamethoxyflavone (HpMF) on macrophage-derived foam cell formation and to further explore the molecular mechanisms. The RAW264.7 macrophage-derived foam cell model was successfully induced by oxidized low-density lipoprotein (ox-LDL) (80 mu g/ml). It showed that TAN, HxMF, and HpMF alleviated ox-LDL-induced NO release while also inhibiting the expression of IL-1 beta, IL-6, and TNF-alpha in RAW264.7 cells. Uptake of excess ox-LDL was inhibited by TAN, HxMF, and HpMF, resulting in the reduction of its foam cell formation. Moreover, TAN, HxMF, and HpMF promoted HDL-mediated cholesterol efflux. Western blot experiment showed that TAN, HxMF, and HpMF inhibited the expression of scavenger receptor class A type I (SRA1) and cluster of differentiation 36 (CD36), while upregulating peroxisome proliferator-activated receptor gamma (PPAR gamma), liver X receptor alpha (LXR alpha), phospholipid ATP-binding cassette transporter G1 (ABCG1), and scavenger receptor class B type I (SRB1) expression. Together, our findings suggested that PMFs inhibited foam cell formation might inhibit lipid uptake via downregulating SRA1/CD36 expression and promote cholesterol efflux from foam cells via upregulating PPAR gamma/LXR alpha/ABCG1/SRB1 expression. This antiatherosclerotic activity is expected to provide new insights into the development of healthcare uses for PMFs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- atherosclerosis
- polymethoxyflavones
- foam cells
- inflammation
- lipid metabolism
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Liang, Pu-Lin
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Liang, Qian-Wen
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He, Pei-Wen
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Chen, Xue-Lian
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Xu, Ya
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Tu, Hai-Sheng
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visa fler...
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Zhang, Liang
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Qiu, Xiao-Hui
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Zhang, Jing
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Huang, Zhi-Hai
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Xu, Wen
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