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Increased Plasma So...
Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms
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- Keindl, Magdalena (författare)
- University of Bergen
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- Fedotkina, Olena (författare)
- University of Bergen
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- du Plessis, Elsa (författare)
- University of Bergen
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- Jain, Ruchi (författare)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
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- Bergum, Brith (författare)
- Karolinska Institutet
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- Mygind Jensen, Troels (författare)
- Steno Diabetes Center Copenhagen,University of Southern Denmark
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- Laustrup Moller, Cathrine (författare)
- Steno Diabetes Center Copenhagen
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- Falhammar, Henrik (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Nyström, Thomas (författare)
- Karolinska Institutet
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- Catrina, Sergiu-Bogdan (författare)
- Karolinska Institute,Karolinska University Hospital
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- Jörneskog, Gun (författare)
- Danderyd Hospital
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM),University of Helsinki
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- Eliasson, Mats (författare)
- Umeå University,Umeå universitet,Avdelningen för medicin
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- Eliasson, Björn, 1959 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Brismar, Kerstin (författare)
- Karolinska Institutet
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- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Berg, Tore Julsrud (författare)
- University of Oslo
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- Appel, Silke (författare)
- University of Bergen
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- Lyssenko, Valeriya (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Bergen
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(creator_code:org_t)
- 2020-10-30
- 2020
- Engelska.
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Ingår i: Frontiers in Endocrinology. - : Frontiers Media S.A.. - 1664-2392. ; 11
- Relaterad länk:
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic beta cells. Further, patients with T1D have 3-4-fold increased risk of developing micro- and macrovascular complications. However, the contribution of immune-related factors contributing to these diabetes complications are poorly understood. Individuals with long-term T1D who do not progress to vascular complications offer a great potential to evaluate end-organ protection. The aim of the present study was to investigate the association of inflammatory protein levels with vascular complications (retinopathy, nephropathy, cardiovascular disease) in individuals with long-term T1D compared to individuals who rapidly progressed to complications. We studied a panel of inflammatory markers in plasma of patients with long-term T1D with (n = 81 and 26) and without (n = 313 and 25) vascular complications from two cross-sectional Scandinavian cohorts (PROLONG and DIALONG) using Luminex technology. A subset of PROLONG individuals (n = 61) was screened for circulating immune cells using multicolor flow cytometry. We found that elevated plasma levels of soluble interleukin-2 receptor alpha (sIL-2R) were positively associated with the complication phenotype. Risk carriers of polymorphisms in the IL2RA and PTPN2 gene region had elevated plasma levels of sIL-2R. In addition, cell surface marker analysis revealed a shift from naive to effector T cells in T1D individuals with vascular complications as compared to those without. In contrast, no difference between the groups was observed either in IL-2R cell surface expression or in regulatory T cell population size. In conclusion, our data indicates that IL2RA and PTPN2 gene variants might increase the risk of developing vascular complications in people with T1D, by affecting sIL-2R plasma levels and potentially lowering T cell responsiveness. Thus, elevated sIL-2R plasma levels may serve as a biomarker in monitoring the risk for developing diabetic complications and thereby improve patient care.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- cardiovascular disease
- Cluster of Differentiation 25 (CD25)
- diabetes complications
- nephropathy
- regulatory T cells
- retinopathy
- sIL-2R
- cardiovascular disease
- Cluster of Differentiation 25 (CD25)
- diabetes complications
- nephropathy
- regulatory T cells
- retinopathy
- sIL-2R
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Keindl, Magdalen ...
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Fedotkina, Olena
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du Plessis, Elsa
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Jain, Ruchi
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Bergum, Brith
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Mygind Jensen, T ...
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visa fler...
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Laustrup Moller, ...
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Falhammar, Henri ...
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Nyström, Thomas
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Catrina, Sergiu- ...
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Jörneskog, Gun
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Groop, Leif
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Eliasson, Mats
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Eliasson, Björn, ...
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Brismar, Kerstin
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Nilsson, Peter M ...
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Berg, Tore Julsr ...
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Appel, Silke
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Lyssenko, Valeri ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Frontiers in End ...
- Av lärosätet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet
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Göteborgs universitet