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WFRF:(Pauksen Karlis)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003331naa a2200361 4500
001oai:DiVA.org:uu-55259
003SwePub
008081017s1995 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1935031
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-552592 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19350312 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Pauksen, Karlisu Uppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion4 aut
2451 0a Specific T and B cell immunity to measles after allogeneic and autologous bone marrow transplantation
264 1c 1995
338 a print2 rdacarrier
520 a Lymphocyte stimulation with measles virus antigen (MLY) and ELISA for measles IgG antibodies were performed on 60 patients after allogeneic bone marrow transplantation (BMT), and on 59 patients after autologous bone marrow transplantation (ABMT). The T cell response was significantly higher in the 75 measles seropositive patients than in the 29 seronegative patients (P < 0.001), but not significantly different from the MLY in the 15 patients with uncertain serologic reactivity. When the patient group was divided according to type of transplant, the T cell response to measles was also significantly higher in seropositive patients than in seronegative patients after both ABMT (P < 0.001) and after BMT (P < 0.05). Twenty-three seronegative children who were measles vaccinated after BMT had a significantly higher T cell response to measles (7100 c.p.m.) than 17 seronegative non-vaccinated children (100 c.p.m.; P < 0.01). No significant difference was seen in the T cell response in 12 seronegative children vaccinated after ABMT (2500 c.p.m.) compared to seven children not vaccinated (2800 c.p.m.; NS). Seroconversion after vaccination was more frequent in children after BMT (20/23; 87%) compared to ABMT (5/12; 42%; P < 0.05) but no significant difference was found in the T cell response. Therefore, most patients who lost IgG antibodies to measles after bone marrow transplantation also lost their T cell response to measles. A T cell response to measles developed in most patients who seroconverted after vaccination. Failure to develop antibodies to measles in ABMT patients after revaccination may depend on a persisting T cell immunity.
653 a MEDICINE
653 a MEDICIN
7001 a Linde, A.4 aut
7001 a Ljungman, P.u Karolinska Institutet4 aut
7001 a Bolme, P.4 aut
7001 a Lönnerholm, Gudmaru Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Lönnerholm4 aut
7001 a Öberg, G.u Uppsala universitet,Institutionen för kvinnors och barns hälsa4 aut
7001 a Sjölin, Janu Uppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion4 aut
7102 a Uppsala universitetb Institutionen för medicinska vetenskaper4 org
7730 t Bone Marrow Transplantationg 16:6, s. 807-813q 16:6<807-813x 0268-3369x 1476-5365
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-55259
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1935031

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