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WFRF:(Sorbe Bengt 1947 )
 

Sökning: WFRF:(Sorbe Bengt 1947 ) > Prophylactic pelvic...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00002987naa a2200361 4500
001oai:DiVA.org:oru-6064
003SwePub
008090319s2008 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-60642 URI
024a https://doi.org/10.3892/ijo.32.5.10112 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Sorbe, Bengt,d 1947-u Örebro universitet,Hälsoakademin4 aut0 (Swepub:oru)bse
2451 0a Prophylactic pelvic irradiation as part of primary therapy in uterine sarcomas
264 c 2008-05-01
264 1b Spandidos Publications,c 2008
338 a print2 rdacarrier
520 a In a complete geographic series of 155 cases of primary uterine sarcomas, prophylactic pelvic irradiation was used as standard postoperative therapy in the majority of the cases. Vaginal brachytherapy was also added as a boost. The histology was leiomyosarcoma in 62 cases (40%), carcinosarcoma in 60 (39%), endometrial stromal sarcoma in 25 (16%), and other types in 8 cases (5%). The primary surgery was extended hysterectomy in 11 cases (7%), simple hysterectomy in 110 (71%), and supravaginal hysterectomy in 12 (8%). In 22 cases (14%) no major surgery was possible. In the complete series, 62 recurrences (40%) were recorded. Local (9%), regional (9%), and distant recurrences (28%) were the most frequent. The type of surgery was associated with the risk of tumor recurrence. Extended surgery reduced the risk of local and regional recurrences. The 5-year overall survival rate was 42% and the recurrence-free survival (RFS) was 37%. The number of mitoses was significantly (P=0.007) associated with survival. The locoregional RFS rate was 75% for patients treated with adjuvant irradiation and 83% for patients treated with primary surgery alone. Serious late tissue reactions from the bladder and intestine occurred in 7% of the irradiated cases. The locoregional tumor control rate was high in this series of patients, but no significant difference was found between patients treated with surgery alone and surgery plus postoperative pelvic irradiation. This was true for all histological subtypes of the uterine sarcomas. However, this was not a randomized study and selection bias cannot be ruled out
653 a Prophylactic pelvic irradiation
653 a uterine sarcomas
653 a MEDICINE
653 a MEDICIN
653 a Cancerepidemiologi
653 a Cancer Epidemiology
700a Johansson, Birgit4 aut
710a Örebro universitetb Hälsoakademin4 org
773t International Journal of Oncologyd : Spandidos Publicationsg 32:5, s. 1111-1117q 32:5<1111-1117x 1019-6439x 1791-2423
856u https://www.spandidos-publications.com/ijo/32/5/1011/download
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-6064
8564 8u https://doi.org/10.3892/ijo.32.5.1011

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