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FältnamnIndikatorerMetadata
00024138naa a2201669 4500
001oai:gup.ub.gu.se/316538
003SwePub
008240528s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-203215
009oai:DiVA.org:uu-485933
009oai:prod.swepub.kib.ki.se:149453227
009oai:DiVA.org:liu-185024
009oai:lup.lub.lu.se:08dd719c-f01e-4a83-8e6a-ec521f7afdcf
0247 a https://gup.ub.gu.se/publication/3165382 URI
0247 a https://doi.org/10.1136/annrheumdis-2021-2217542 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2032152 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4859332 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1494532272 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1850242 URI
0247 a https://lup.lub.lu.se/record/08dd719c-f01e-4a83-8e6a-ec521f7afdcf2 URI
040 a (SwePub)gud (SwePub)umud (SwePub)uud (SwePub)kid (SwePub)liud (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Saevarsdottir, S.u Karolinska Institutet,deCODE Genet Amgen, Iceland; Karolinska Inst, Sweden; Univ Iceland, Iceland; Natl Univ Hosp Iceland, Iceland,University of Iceland4 aut
2451 0a Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
264 c 2022-04-25
264 1b BMJ,c 2022
500 a Funding Agencies|NORDFORSK [90825]; Swedish Research Council [2018-02803]; Swedish innovation Agency (Vinnova); Innovationsfonden; The Research Council of Norway; Region Stockholm-Karolinska Institutet; Region Vasterbotten (ALF); Danish Rheumatism Association [R194-A6956, A1923, A3037, A3570]; Swedish Brain Foundation; Nils and Bibbi Jensens Foundation; Knut and Alice Wallenberg Foundation; Margaretha af Ugglas Foundation; South-Eastern Heath Region of Norway; Health Research Fund of Central Denmark Region; Region of Southern Denmark; A.P. Moller Foundation for the Advancement of Medical Science; Colitis-Crohn Foreningen; Novo Nordisk Foundation [NNF15OC0016932]; Aase og Ejnar Danielsens Fond; Beckett-Fonden; Augustinus Fonden; Knud and Edith Eriksens Mindefond; Laege Sofus Carl Emil Friis and Hustru Olga Doris Friis Legat; Psoriasis Forskningsfonden; University of Aarhus; Region of Southern Denmarks PhD Fund [12/7725]; Department of Rheumatology, Frederiksberg Hospital; Research Council of Norway [229624, 223273]; South East and Western Norway Health Authorities; ERC AdG project SELECTionPREDISPOSED; Stiftelsen Kristian Gerhard Jebsen; Trond Mohn Foundation; Novo Nordisk Foundation; University of Bergen
520 a Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and similar to 1 million controls from Northwestern Europe. We searched for causal genes outside the HLA-locus through effect on coding, mRNA expression in several tissues and/or levels of plasma proteins (SomaScan) and did network analysis (Qiagen). Results We found 25 sequence variants for RA overall, 33 for seropositive and 2 for seronegative RA, altogether 37 sequence variants at 34 non-HLA loci, of which 15 are novel. Genomic, transcriptomic and proteomic analysis of these yielded 25 causal genes in seropositive RA and additional two overall. Most encode proteins in the network of interferon-alpha/beta and IL-12/23 that signal through the JAK/STAT-pathway. Highlighting those with largest effect on seropositive RA, a rare missense variant in STAT4 (rs140675301-A) that is independent of reported non-coding STAT4-variants, increases the risk of seropositive RA 2.27-fold (p=2.1x10(-9)), more than the rs2476601-A missense variant in PTPN22 (OR=1.59, p=1.3x10(-160)). STAT4 rs140675301-A replaces hydrophilic glutamic acid with hydrophobic valine (Glu128Val) in a conserved, surface-exposed loop. A stop-mutation (rs76428106-C) in FLT3 increases seropositive RA risk (OR=1.35, p=6.6x10(-11)). Independent missense variants in TYK2 (rs34536443-C, rs12720356-C, rs35018800-A, latter two novel) associate with decreased risk of seropositive RA (ORs=0.63-0.87, p=10(-9)-10(-27)) and decreased plasma levels of interferon-alpha/beta receptor 1 that signals through TYK2/JAK1/STAT4. Conclusion Sequence variants pointing to causal genes in the JAK/STAT pathway have largest effect on seropositive RA, while associations with seronegative RA remain scarce.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653 a rheumatoid arthritis
653 a autoantibodies
653 a polymorphism
653 a genetic
653 a DNA-binding
653 a stat4
653 a classification
653 a association
653 a inhibitor
653 a criteria
653 a cells
653 a fms
653 a Rheumatology
653 a autoantibodies
7001 a Stefansdottir, L.4 aut
7001 a Sulem, P.u DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.4 aut
7001 a Thorleifsson, G.u DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.4 aut
7001 a Ferkingstad, E.u DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.4 aut
7001 a Rutsdottir, G.u DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.4 aut
7001 a Glintborg, B.u Danish Rheumatologic Biobank and Copenhagen Center for Arthritis Research (COPECARE), Centre for Rheumatology and Spine Diseases, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Copenhagen Univ Hosp, Rigshosp, Copenhagen Ctr Arthrit Res COPECARE, Ctr Rheumatol & Spine Dis,Ctr Head & Orthopaed, Glostrup, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.4 aut
7001 a Westerlind, H.u Karolinska Institutet,Karolinska Inst, Sweden4 aut
7001 a Grondal, G.u Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Medicine, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland; Center for Rheumatology Research, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark,Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Dept Med, Landspitali, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Ctr Rheumatol Res, Landspitali, Reykjavik, Iceland.,Aarhus Univ Hosp, Dept Rheumatol, Aarhus, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.4 aut
7001 a Loft, I. C.u Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark,Zealand Univ Hosp, Dept Clin Immunol, Koge, Denmark.4 aut
7001 a Sorensen, S. B.u Molecular Diagnostics and Clinical Research Unit, IRS-Center Sonderjylland, University Hospital of Southern Denmark, Aabenraa, Denmark,Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Oslo, Dept Med Genet, Oslo, Norway.,Univ Hosp Southern Denmark, IRS Ctr Sonderjylland, Mol Diagnost & Clin Res Unit, Aabenraa, Denmark.,Univ Copenhagen, Novo Nordisk Fdn Ctr Prot Res, Fac Hlth & Med Sci, Copenhagen, Denmark.4 aut
7001 a Lie, B. A.u Karolinska Institutet,Univ Oslo, Norway; Oslo Univ Hosp, Norway4 aut
7001 a Brink, Mikaelu Umeå universitet,Reumatologi,Umeå Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umeå, Sweden.4 aut0 (Swepub:umu)mibr0003
7001 a Ärlestig, Lisbeth,d 1954-u Umeå universitet,Reumatologi,Umeå Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umeå, Sweden.4 aut0 (Swepub:umu)litarg99
7001 a Arnthorsson, A. O.u DeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland,NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.,Univ Oslo, NORMENT Ctr, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.4 aut
7001 a Baecklund, Eva,d 1956-u Uppsala universitet,Reumatologi,Uppsala Univ, Sweden4 aut0 (Swepub:uu)evaba786
7001 a Banasik, K.u Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Novo Nordisk Fdn Ctr Prot Res, Fac Hlth & Med Sci, Copenhagen, Denmark.4 aut
7001 a Bank, S.4 aut
7001 a Björkman, Lena,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.4 aut0 (Swepub:gu)xblenv
7001 a Ellingsen, T.u OPEN Explorative Network, University of Southern Denmark, Odense, Denmark; Rheumatology Research Unit, Odense University Hospital and University of Southern Denmark, Odense, Denmark,Univ Southern Denmark, Open Explorat Network, Odense, Denmark.;Odense Univ Hosp, Rheumatol Res Unit, Odense, Denmark.;Univ Southern Denmark, Odense, Denmark.4 aut
7001 a Erikstrup, C.u Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Clin Immunol, Aarhus, Denmark.4 aut
7001 a Frei, O.u NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway,Univ Oslo, NORMENT Ctr, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.;Univ Oslo, Ctr Bioinformat, Dept Informat, Oslo, Norway.4 aut
7001 a Gjertsson, Inger,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Department of Rheumatology and Inflammation Research, Gothenburg University, Gothenburg, Sweden,Gothenburg Univ, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.4 aut0 (Swepub:gu)xgjein
7001 a Gudbjartsson, D. F.u DeCODE Genetics/Amgen, Reykjavik, Iceland; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Sch Engn & Nat Sci, Reykjavik, Iceland.4 aut
7001 a Gudjonsson, S. A.u DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.4 aut
7001 a Halldorsson, G. H.u DeCODE Genetics/Amgen, Reykjavik, Iceland; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Sch Engn & Nat Sci, Reykjavik, Iceland.4 aut
7001 a Hendricks, O.u Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sønderborg, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark,Univ Hosp Southern Denmark, Danish Hosp Rheumat Dis, Sonderborg, Denmark.;Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark.4 aut
7001 a Hillert, J.u Karolinska Institutet,Karolinska Inst, Sweden4 aut
7001 a Hogdall, E.u Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Herlev Hosp, Dept Pathol, Copenhagen, Denmark.4 aut
7001 a Jacobsen, S.u Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.;Rigshosp, Ctr Rheumatol & Spine Dis, Copenhagen Lupus & Vasculitis Clin, Copenhagen, Denmark.4 aut
7001 a Jensen, D. V.u Department of Rheumatology, Center for Rheumatology and Spine Diseases, Gentofte and Herlev Hospital, Rønne, Denmark,Gentofte & Herlev Hosp, Ctr Rheumatol & Spine Dis, Dept Rheumatol, Ronne, Denmark.4 aut
7001 a Jonsson, H.u Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Medicine, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Dept Med, Landspitali, Reykjavik, Iceland.4 aut
7001 a Kastbom, Alfu Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland4 aut0 (Swepub:liu)alfka05
7001 a Kockum, I.u Karolinska Institutet,Karolinska Inst, Sweden4 aut
7001 a Kristensen, S.u Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark,Aalborg Univ Hosp, Dept Rheumatol, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.,University of Iceland4 aut
7001 a Kristjansdottir, H.u Center for Rheumatology Research, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,Natl Univ Hosp Iceland, Ctr Rheumatol Res, Landspitali, Reykjavik, Iceland.4 aut
7001 a Larsen, M. H.u Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark,OPEN Explorative Network, University of Southern Denmark, Odense, Denmark; Rheumatology Research Unit, Odense University Hospital and University of Southern Denmark, Odense, Denmark,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,Univ Southern Denmark, Open Explorat Network, Odense, Denmark.;Odense Univ Hosp, Rheumatol Res Unit, Odense, Denmark.;Univ Southern Denmark, Odense, Denmark.4 aut
7001 a Linauskas, A.u Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Department of Rheumatology, North Denmark Regional Hospital, Hjørring, Denmark,Aalborg Univ, Dept Clin Med, Aalborg, Denmark.;North Denmark Reg Hosp, Dept Rheumatol, Hjorring, Denmark.4 aut
7001 a Hauge, E. M.u Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark,Aarhus Univ Hosp, Dept Rheumatol, Aarhus, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.4 aut
7001 a Loft, A. G.4 aut
7001 a Ludviksson, B. R.u Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Immunology, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Dept Immunol, Landspitali, Reykjavik, Iceland.4 aut
7001 a Lund, S. H.u DeCODE Genetics/Amgen, Reykjavik, Iceland,Section of Rheumatology, Oslo University Hospital, Oslo, Norway; Oslo New University College, Oslo, Norway,deCODE Genet Amgen, Reykjavik, Iceland.,Oslo Univ Hosp, Sect Rheumatol, Oslo, Norway.;Oslo New Univ Coll, Oslo, Norway.4 aut
7001 a Markusson, T.u DeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.4 aut
7001 a Masson, G.u DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.4 aut
7001 a Melsted, P.u DeCODE Genetics/Amgen, Reykjavik, Iceland; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Sch Engn & Nat Sci, Reykjavik, Iceland.4 aut
7001 a Moore, K. H. S.u Center for Rheumatology Research, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,DeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland,Natl Univ Hosp Iceland, Ctr Rheumatol Res, Landspitali, Reykjavik, Iceland.,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.4 aut
7001 a Munk, H.4 aut
7001 a Nielsen, K. R.u Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark,Aalborg Univ Hosp, Dept Clin Immunol, Aalborg, Denmark.4 aut
7001 a Norddahl, G. L.u DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.4 aut
7001 a Oddsson, A.4 aut
7001 a Olafsdottir, T. A.4 aut
7001 a Olason, P. I.u DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.4 aut
7001 a Olsson, T.u Karolinska Institutet,Karolinska Inst, Sweden4 aut
7001 a Ostrowski, S. R.u Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark,DeCODE Genetics/Amgen, Reykjavik, Iceland,Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.;Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,deCODE Genet Amgen, Reykjavik, Iceland.4 aut
7001 a Horslev-Petersen, K.u Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sønderborg, Denmark,Univ Hosp Southern Denmark, Danish Hosp Rheumat Dis, Sonderborg, Denmark.4 aut
7001 a Rognvaldsson, S.4 aut
7001 a Sanner, H.4 aut
7001 a Silberberg, G. N.u Division of Rheumatology, Department of Medicine, Solna Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Med, Div Rheumatol, Stockholm, Sweden.4 aut
7001 a Stefansson, H.4 aut
7001 a Sorensen, E.u Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.4 aut
7001 a Sorensen, I. J.u DeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Immunology, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Dept Immunol, Landspitali, Reykjavik, Iceland.4 aut
7001 a Turesson, C.u Lund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups4 aut0 (Swepub:lu)med-ctn
7001 a Bergman, T.u Division of Clinical Epidemiology, Department of Medicine, Solna Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Med, Div Clin Epidemiol, Stockholm, Sweden.4 aut
7001 a Alfredsson, L.u Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden.4 aut
7001 a Kvien, T. K.u University of Oslo, Oslo, Norway; Diakonhjemmet Hospital, Oslo, Norway,Univ Oslo, Oslo, Norway.;Diakonhjemmet Hosp, Oslo, Norway.4 aut
7001 a Brunak, S.4 aut
7001 a Steinsson, K.4 aut
7001 a Andersen, V.u Molecular Diagnostics and Clinical Research Unit, IRS-Center Sonderjylland, University Hospital of Southern Denmark, Aabenraa, Denmark; OPEN Explorative Network, University of Southern Denmark, Odense, Denmark; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark,Univ Hosp Southern Denmark, IRS Ctr Sonderjylland, Mol Diagnost & Clin Res Unit, Aabenraa, Denmark.;Univ Southern Denmark, Open Explorat Network, Odense, Denmark.;Univ Southern Denmark, Inst Mol Med, Odense, Denmark.4 aut
7001 a Andreassen, O. A.4 aut
7001 a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi,Umeå Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umeå, Sweden.4 aut0 (Swepub:umu)sora0001
7001 a Hetland, M. L.u Danish Rheumatologic Biobank and Copenhagen Center for Arthritis Research (COPECARE), Centre for Rheumatology and Spine Diseases, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Copenhagen Univ Hosp, Rigshosp, Copenhagen Ctr Arthrit Res COPECARE, Ctr Rheumatol & Spine Dis,Ctr Head & Orthopaed, Glostrup, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.4 aut
7001 a Klareskog, L.u Karolinska Institutet,Karolinska Inst, Sweden4 aut
7001 a Askling, J.u Karolinska Institutet,Karolinska Inst, Sweden4 aut
7001 a Padyukov, L.u Karolinska Institutet,Karolinska Inst, Sweden4 aut
7001 a Pedersen, O. B.u Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark,Zealand Univ Hosp, Dept Clin Immunol, Koge, Denmark.4 aut
7001 a Thorsteinsdottir, U.u DeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.4 aut
7001 a Jonsdottir, I.4 aut
7001 a Stefansson, K.4 aut
7102 a Karolinska Institutetb deCODE Genet Amgen, Iceland; Karolinska Inst, Sweden; Univ Iceland, Iceland; Natl Univ Hosp Iceland, Iceland4 org
7730 t Annals of the Rheumatic Diseasesd : BMJg 81:8q 81:8x 0003-4967x 1468-2060
8564 u https://doi.org/10.1136/annrheumdis-2021-221754y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1728514/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://uu.diva-portal.org/smash/get/diva2:1700614/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://liu.diva-portal.org/smash/get/diva2:1661009/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1136/annrheumdis-2021-221754x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/316538
8564 8u https://doi.org/10.1136/annrheumdis-2021-221754
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203215
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485933
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:149453227
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185024
8564 8u https://lup.lub.lu.se/record/08dd719c-f01e-4a83-8e6a-ec521f7afdcf

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