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Polymorphous adenoc...
Polymorphous adenocarcinoma of the salivary glands: reappraisal and update
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Vander Poorten, V. (author)
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Triantafyllou, A. (author)
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Skalova, A. (author)
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- Stenman, Göran, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Sahlgrenska Cancer Center,Institute of Biomedicine, Department of Pathology
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Bishop, J. A. (author)
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Hauben, E. (author)
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Hunt, J. L. (author)
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Hellquist, H. (author)
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Feys, S. (author)
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De Bree, R. (author)
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- Makitie, A. (author)
- Karolinska Institutet
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Quer, M. (author)
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Strojan, P. (author)
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Guntinas-Lichius, O. (author)
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Rinaldo, A. (author)
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Ferlito, A. (author)
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(creator_code:org_t)
- 2018-05-14
- 2018
- English.
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In: European Archives of Oto-Rhino-Laryngology. - : Springer Science and Business Media LLC. - 0937-4477 .- 1434-4726. ; 275:7, s. 1681-1695
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Abstract
Subject headings
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- Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Keyword
- Polymorphous adenocarcinoma
- Pathology
- Salivary glands
- Therapy
- Prognosis
- Polymorphous low-
- low-grade adenocarcinoma
- adenoid cystic carcinoma
- needle-aspiration-cytology
- lymph-node metastasis
- term-follow-up
- cribriform adenocarcinoma
- neck-cancer
- malignant-tumors
- oral-cavity
- case series
- Otorhinolaryngology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Vander Poorten, ...
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Triantafyllou, A ...
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Skalova, A.
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Stenman, Göran, ...
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Bishop, J. A.
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Hauben, E.
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show more...
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Hunt, J. L.
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Hellquist, H.
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Feys, S.
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De Bree, R.
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Makitie, A.
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Quer, M.
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Strojan, P.
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Guntinas-Lichius ...
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Rinaldo, A.
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Ferlito, A.
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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MEDICAL AND HEAL ...
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and Otorhinolaryngol ...
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University of Gothenburg
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Karolinska Institutet