Sökning: WFRF:(Thurston T.) > Astrocyte reactivit...
Fältnamn | Indikatorer | Metadata |
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000 | 04870naa a2200649 4500 | |
001 | oai:gup.ub.gu.se/329944 | |
003 | SwePub | |
008 | 240910s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3299442 URI |
024 | 7 | a https://doi.org/10.1038/s41591-023-02380-x2 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bellaver, B.4 aut |
245 | 1 0 | a Astrocyte reactivity influences amyloid-beta effects on tau pathology in preclinical Alzheimer's disease |
264 | 1 | c 2023 |
520 | a Cross-sectional and longitudinal analyses of tau pathology in preclinical Alzheimer's disease reveal that tau tangles accumulate as a function of amyloid-beta burden only in individuals positive for an astrocyte reactivity biomarker. An unresolved question for the understanding of Alzheimer's disease (AD) pathophysiology is why a significant percentage of amyloid-beta (A beta)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream tau pathology and, consequently, clinical deterioration. In vitro evidence suggests that reactive astrocytes unleash A beta effects in pathological tau phosphorylation. Here, in a biomarker study across three cohorts (n = 1,016), we tested whether astrocyte reactivity modulates the association of A beta with tau phosphorylation in CU individuals. We found that A beta was associated with increased plasma phosphorylated tau only in individuals positive for astrocyte reactivity (Ast(+)). Cross-sectional and longitudinal tau-positron emission tomography analyses revealed an AD-like pattern of tau tangle accumulation as a function of A beta only in CU Ast(+) individuals. Our findings suggest astrocyte reactivity as an important upstream event linking A beta with initial tau pathology, which may have implications for the biological definition of preclinical AD and for selecting CU individuals for clinical trials. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
700 | 1 | a Povala, G.4 aut |
700 | 1 | a Ferreira, P. C. L.4 aut |
700 | 1 | a Ferrari-Souza, J. P.4 aut |
700 | 1 | a Leffa, D. T.4 aut |
700 | 1 | a Lussier, F. Z.4 aut |
700 | 1 | a Lessa Benedet, Andréau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlesan |
700 | 1 | a Ashton, Nicholas J.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xashtn |
700 | 1 | a Triana-Baltzer, G.4 aut |
700 | 1 | a Kolb, H. C.4 aut |
700 | 1 | a Tissot, C.4 aut |
700 | 1 | a Therriault, J.4 aut |
700 | 1 | a Servaes, S.4 aut |
700 | 1 | a Stevenson, J.4 aut |
700 | 1 | a Rahmouni, N.4 aut |
700 | 1 | a Lopez, O. L.4 aut |
700 | 1 | a Tudorascu, D. L.4 aut |
700 | 1 | a Villemagne, V. L.4 aut |
700 | 1 | a Ikonomovic, M. D.4 aut |
700 | 1 | a Gauthier, S.4 aut |
700 | 1 | a Zimmer, E. R.4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Aizenstein, H. J.4 aut |
700 | 1 | a Klunk, W. E.4 aut |
700 | 1 | a Snitz, B. E.4 aut |
700 | 1 | a Maki, P.4 aut |
700 | 1 | a Thurston, R. C.4 aut |
700 | 1 | a Cohen, A. D.4 aut |
700 | 1 | a Ganguli, M.4 aut |
700 | 1 | a Karikari, Thomasu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xkarit |
700 | 1 | a Rosa-Neto, P.4 aut |
700 | 1 | a Pascoal, T. A.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Nature Medicineg 29:7q 29:7x 1078-8956 |
856 | 4 8 | u https://gup.ub.gu.se/publication/329944 |
856 | 4 8 | u https://doi.org/10.1038/s41591-023-02380-x |
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