Rise and fall of NT-proBNP in aortic valve intervention.

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Fältnamn	Indikatorer	Metadata
000		03889naa a2200373 4500
001		oai:DiVA.org:liu-149013
003		SwePub
008		180625s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1490132 URI
024	7	a https://doi.org/10.1136/openhrt-2017-0007392 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hultkvist, Henrik,d 1968-u Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland4 aut0 (Swepub:liu)henhu71
245	1 0	a Rise and fall of NT-proBNP in aortic valve intervention.
264		c 2018-04-01
264	1	b BMJ,c 2018
338		a print2 rdacarrier
520		a Objectives: To describe the dynamics of N-terminal pro-B-type natriuretic peptide (NT-proBNP) from preoperative evaluation to 6-month follow-up in patients undergoing aortic valve intervention, and to evaluate NT-proBNP with regard to 1-year mortality.Methods: At preoperative evaluation, we prospectively included 462 patients accepted for aortic valve intervention. The median time to surgical aortic valve replacement (SAVR; n=336) or transcatheter aortic valve implantation (TAVI; n=126) was 4 months. NT-proBNP was measured at enrolment for preoperative evaluation, on the day of surgery, postoperatively on day 1, day 3 and at the 6-month follow-up. Subgroups of patients undergoing SAVR with aortic regurgitation and aortic stenosis with and without coronary artery bypass were also analysed.Results: NT-proBNP remained stable in all subgroups during the preoperative waiting period, but displayed a substantial transient early postoperative increase with a peak on day 3 except in the TAVI group, which peaked on day 1. At the 6-month follow-up, NT-proBNP had decreased to or below the preoperative level in all groups. In the SAVR group, NT-proBNP preoperatively and on postoperative days 1 and 3 revealed significant discriminatory power with regard to 1-year mortality (area under the curve (AUC)=0.79, P=0.0001; AUC=0.71, P=0.03; and AUC=0.79, P=0.002, respectively). This was not found in the TAVI group, which had higher levels of NT-proBNP both preoperatively and at the 6-month follow-up compared with the SAVR group.Conclusions: The dynamic profile of NT-proBNP differed between patients undergoing TAVI and SAVR. NT-proBNP in the perioperative course was associated with increased risk of 1-year mortality in SAVR but not in TAVI.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653		a aortic valve disease
653		a heart failure
653		a surgery-valve
700	1	a Holm, Jonas,d 1971-u Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland4 aut0 (Swepub:liu)jonho41
700	1	a Svedjeholm, Rolf,d 1952-u Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland4 aut0 (Swepub:liu)rolsv84
700	1	a Vánky, Farkasu Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland4 aut0 (Swepub:liu)farva32
710	2	a Linköpings universitetb Avdelningen för kardiovaskulär medicin4 org
773	0	t Open heartd : BMJg 5:1q 5:1x 2053-3624
856	4	u https://openheart.bmj.com/content/openhrt/5/1/e000739.full.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-149013
856	4 8	u https://doi.org/10.1136/openhrt-2017-000739

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Av författaren/redakt...: Hultkvist, Henri ...; Holm, Jonas, 197 ...; Svedjeholm, Rolf ...; Vánky, Farkas

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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Av lärosätet: Linköpings universitet

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