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Sökning: WFRF:(Campbell Steven) > Differential Neural...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003189naa a2200409 4500
001oai:DiVA.org:uu-157042
003SwePub
008110815s2011 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1570422 URI
024a https://doi.org/10.1371/journal.pone.00222592 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Brooks, Samantha J.u Uppsala universitet,Funktionell farmakologi4 aut0 (Swepub:uu)sambr210
2451 0a Differential Neural Responses to Food Images in Women with Bulimia versus Anorexia Nervosa
264 c 2011-07-20
264 1b Public Library of Science (PLoS),c 2011
338 a print2 rdacarrier
520 a Background: Previous fMRI studies show that women with eating disorders (ED) have differential neural activation to viewing food images. However, despite clinical differences in their responses to food, differential neural activation to thinking about eating food, between women with anorexia nervosa (AN) and bulimia nervosa (BN) is not known. Methods: We compare 50 women (8 with BN, 18 with AN and 24 age-matched healthy controls [HC]) while they view food images during functional Magnetic Resonance Imaging (fMRI). Results: In response to food (vs non-food) images, women with BN showed greater neural activation in the visual cortex, right dorsolateral prefrontal cortex, right insular cortex and precentral gyrus, women with AN showed greater activation in the right dorsolateral prefrontal cortex, cerebellum and right precuneus. HC women activated the cerebellum, right insular cortex, right medial temporal lobe and left caudate. Direct comparisons revealed that compared to HC, the BN group showed relative deactivation in the bilateral superior temporal gyrus/insula, and visual cortex, and compared to AN had relative deactivation in the parietal lobe and dorsal posterior cingulate cortex, but greater activation in the caudate, superior temporal gyrus, right insula and supplementary motor area. Conclusions: Women with AN and BN activate top-down cognitive control in response to food images, yet women with BN have increased activation in reward and somatosensory regions, which might impinge on cognitive control over food consumption and binge eating.
653 a MEDICINE
653 a MEDICIN
700a O'Daly, Owen G.4 aut
700a Uher, Rudolf4 aut
700a Friederich, Hans-Christoph4 aut
700a Giampietro, Vincent4 aut
700a Brammer, Michael4 aut
700a Williams, Steven C. R.4 aut
700a Schiöth, Helgi B.u Uppsala universitet,Funktionell farmakologi4 aut0 (Swepub:uu)helgschi
700a Treasure, Janet4 aut
700a Campbell, Iain C.4 aut
710a Uppsala universitetb Funktionell farmakologi4 org
773t PLOS ONEd : Public Library of Science (PLoS)g 6:7, s. e22259-q 6:7<e22259-x 1932-6203
856u https://doi.org/10.1371/journal.pone.0022259
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-157042
8564 8u https://doi.org/10.1371/journal.pone.0022259

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