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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007549naa a2200685 4500
001oai:lup.lub.lu.se:2487f2ad-8be0-49c1-b3b2-9f1b72524992
003SwePub
008191010s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/2487f2ad-8be0-49c1-b3b2-9f1b725249922 URI
0247 a https://doi.org/10.1161/CIRCRESAHA.119.3153802 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Georgakis, Marios K.u University Hospital Munich,Ludwig-Maximilian University of Munich4 aut
2451 0a Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke : Meta-Analysis of Population-Based Studies Involving 17 180 Individuals
264 1c 2019
300 a 10 s.
520 a Rationale: Proinflammatory cytokines have been identified as potential targets for lowering vascular risk. Experimental evidence and Mendelian randomization suggest a role of MCP-1 (monocyte chemoattractant protein-1) in atherosclerosis and stroke. However, data from large-scale observational studies are lacking. Objective: To determine whether circulating levels of MCP-1 are associated with risk of incident stroke in the general population. Methods and Results: We used previously unpublished data on 17 180 stroke-free individuals (mean age, 56.7±8.1 years; 48.8% men) from 6 population-based prospective cohort studies and explored associations between baseline circulating MCP-1 levels and risk of any stroke, ischemic stroke, and hemorrhagic stroke during a mean follow-up interval of 16.3 years (280 522 person-years at risk; 1435 incident stroke events). We applied Cox proportional-hazards models and pooled hazard ratios (HRs) using random-effects meta-analyses. After adjustments for age, sex, race, and vascular risk factors, higher MCP-1 levels were associated with increased risk of any stroke (HR per 1-SD increment in ln-transformed MCP-1, 1.07; 95% CI, 1.01-1.14). Focusing on stroke subtypes, we found a significant association between baseline MCP-1 levels and higher risk of ischemic stroke (HR, 1.11 [1.02-1.21]) but not hemorrhagic stroke (HR, 1.02 [0.82-1.29]). The results followed a dose-response pattern with a higher risk of ischemic stroke among individuals in the upper quartiles of MCP-1 levels as compared with the first quartile (HRs, second quartile: 1.19 [1.00-1.42]; third quartile: 1.35 [1.14-1.59]; fourth quartile: 1.38 [1.07-1.77]). There was no indication for heterogeneity across studies, and in a subsample of 4 studies (12 516 individuals), the risk estimates were stable after additional adjustments for circulating levels of IL (interleukin)-6 and high-sensitivity CRP (C-reactive protein). Conclusions: Higher circulating levels of MCP-1 are associated with increased long-term risk of stroke. Our findings along with genetic and experimental evidence suggest that MCP-1 signaling might represent a therapeutic target to lower stroke risk.Visual Overview: An online visual overview is available for this article.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a atherosclerosis
653 a cerebrovascular disorders
653 a chemokine CCL2
653 a inflammation
653 a stroke
7001 a Malik, Raineru University Hospital Munich,Ludwig-Maximilian University of Munich4 aut
7001 a Björkbacka, Harryu Lund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups4 aut0 (Swepub:lu)medf-hbj
7001 a Pana, Tiberiu Alexandruu University of Aberdeen4 aut
7001 a Demissie, Serkalemu Framingham Heart Study,Boston University4 aut
7001 a Ayers, Colbyu University of Texas Southwestern Medical Center4 aut
7001 a Elhadad, Mohamed A.u German Centre for Cardiovascular Research,Helmholtz Zentrum München4 aut
7001 a Fornage, Myriamu University of Texas Health Science Centre4 aut
7001 a Beiser, Alexa S.u Framingham Heart Study,Boston University4 aut
7001 a Benjamin, Emelia J.u Boston University,Framingham Heart Study4 aut
7001 a Boekholdt, Matthijs S.u Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen
7001 a Herder, Christianu Heinrich Heine University Düsseldorf4 aut
7001 a Hoogeveen, Ron C.u Baylor College of Medicine4 aut
7001 a Koenig, Wolfgangu University of Ulm,German Centre for Cardiovascular Research,Technical University of Munich4 aut
7001 a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
7001 a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
7001 a Schiopu, Alexandruu Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-asc
7001 a Söderholm, Martinu Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-ms8
7001 a Wareham, Nicku University of Cambridge4 aut
7001 a Ballantyne, Christie M.u Baylor College of Medicine4 aut
7001 a Peters, Annetteu Helmholtz Zentrum München4 aut
7001 a Seshadri, Sudhau Boston University,University of Texas Health Science Centre,Framingham Heart Study4 aut
7001 a Myint, Phyo K.u University of Aberdeen4 aut
7001 a Nilsson, Janu Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups4 aut0 (Swepub:lu)medf-jni
7001 a de Lemos, James A.u University of Texas Southwestern Medical Center4 aut
7001 a Dichgans, Martinu German Center for Neurodegenerative Diseases (DZNE), Bonn,Munich Cluster for Systems Neurology,University Hospital Munich4 aut
7102 a University Hospital Munichb Ludwig-Maximilian University of Munich4 org
7730 t Circulation Researchg 125:8, s. 773-782q 125:8<773-782x 0009-7330
8564 u http://dx.doi.org/10.1161/CIRCRESAHA.119.315380y FULLTEXT
8564 8u https://lup.lub.lu.se/record/2487f2ad-8be0-49c1-b3b2-9f1b72524992
8564 8u https://doi.org/10.1161/CIRCRESAHA.119.315380

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