Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric Disorders.

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Fältnamn	Indikatorer	Metadata
000		04524naa a2200841 4500
001		oai:gup.ub.gu.se/332977
003		SwePub
008		240910s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:237034613
024	7	a https://gup.ub.gu.se/publication/3329772 URI
024	7	a https://doi.org/10.21203/rs.3.rs-2720355/v12 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:2370346132 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Repetto, Linda4 aut
245	1 0	a Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric Disorders.
264	1	b Research Square Platform LLC,c 2023
520		a Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioral traits and the disease etiology of neuropsychiatric disorders. Here, the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,500 individuals for 184 neuro-related proteins in human plasma. The analysis identified 117 cis-regulatory protein quantitative trait loci (cis-pQTL) and 166 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. Mendelian randomization analyses revealed multiple proteins showing potential causal effects on neuro-related traits such as sleeping, smoking, feelings, alcohol intake, mental health, and psychiatric disorders. Integrating with established drug information, we validated 13 out of 13 matched combinations of protein targets and diseases or side effects with available drugs, while suggesting hundreds of re-purposing and new therapeutic targets. This consortium effort provides a large-scale proteogenomic resource for biomedical research on human behaviors and other neuro-related phenotypes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
700	1	a Chen, Jiantao4 aut
700	1	a Yang, Zhijian4 aut
700	1	a Zhai, Ranran4 aut
700	1	a Timmers, Paul R H J4 aut
700	1	a Li, Ting4 aut
700	1	a Twait, Emma L4 aut
700	1	a May-Wilson, Sebastian4 aut
700	1	a Muckian, Marisa D4 aut
700	1	a Prins, Bram P4 aut
700	1	a Png, Grace4 aut
700	1	a Kooperberg, Charles4 aut
700	1	a Johansson, Åsa4 aut
700	1	a Hillary, Robert F4 aut
700	1	a Wheeler, Eleanor4 aut
700	1	a Pan, Luu Karolinska Institutet4 aut
700	1	a He, Yazhou4 aut
700	1	a Klasson, Sofia4 aut
700	1	a Ahmad, Shahzad4 aut
700	1	a Peters, James E4 aut
700	1	a Gilly, Arthur4 aut
700	1	a Karaleftheri, Maria4 aut
700	1	a Tsafantakis, Emmanouil4 aut
700	1	a Haessler, Jeffrey4 aut
700	1	a Gyllensten, Ulf4 aut
700	1	a Harris, Sarah E4 aut
700	1	a Wareham, Nicholas J4 aut
700	1	a Göteson, Andreas4 aut
700	1	a Lagging, Cecilia4 aut
700	1	a Ikram, Mohammad Arfan4 aut
700	1	a van Duijn, Cornelia M4 aut
700	1	a Jern, Christina4 aut
700	1	a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
700	1	a Langenberg, Claudia4 aut
700	1	a Deary, Ian J4 aut
700	1	a Marioni, Riccardo E4 aut
700	1	a Enroth, Stefan4 aut
700	1	a Reiner, Alexander P4 aut
700	1	a Dedoussis, George4 aut
700	1	a Zeggini, Eleftheria4 aut
700	1	a Butterworth, Adam S4 aut
700	1	a Mälarstig, Anders4 aut
700	1	a Wilson, James F4 aut
700	1	a Navarro, Pau4 aut
700	1	a Shen, Xia4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Nature Portfoliod : Research Square Platform LLC
773	0	t Research squared : Research Square Platform LLCx 2693-5015
856	4 8	u https://gup.ub.gu.se/publication/332977
856	4 8	u https://doi.org/10.21203/rs.3.rs-2720355/v1
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:237034613

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Av författaren/redakt...: Repetto, Linda; Chen, Jiantao; Yang, Zhijian; Zhai, Ranran; Timmers, Paul R ...; Li, Ting; visa fler...; Twait, Emma L; May-Wilson, Seba ...; Muckian, Marisa ...; Prins, Bram P; Png, Grace; Kooperberg, Char ...; Johansson, Åsa; Hillary, Robert ...; Wheeler, Eleanor; Pan, Lu; He, Yazhou; Klasson, Sofia; Ahmad, Shahzad; Peters, James E; Gilly, Arthur; Karaleftheri, Ma ...; Tsafantakis, Emm ...; Haessler, Jeffre ...; Gyllensten, Ulf; Harris, Sarah E; Wareham, Nichola ...; Göteson, Andreas; Lagging, Cecilia; Ikram, Mohammad ...; van Duijn, Corne ...; Jern, Christina; Landén, Mikael, ...; Langenberg, Clau ...; Deary, Ian J; Marioni, Riccard ...; Enroth, Stefan; Reiner, Alexande ...; Dedoussis, Georg ...; Zeggini, Elefthe ...; Butterworth, Ada ...; Mälarstig, Ander ...; Wilson, James F; Navarro, Pau; Shen, Xia; visa färre...

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