WFRF:(MacPherson S.)
Sökning: WFRF:(MacPherson S.) > Steady-state migrat...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03754naa a2200781 4500 | |
| 001 | oai:gup.ub.gu.se/104287 | |
| 003 | SwePub | |
| 008 | 240528s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1042872 URI |
| 024 | 7 | a https://doi.org/10.1038/mi.2008.712 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Milling, S W F4 aut |
| 245 | 1 0 | a Steady-state migrating intestinal dendritic cells induce potent inflammatory responses in naive CD4+ T cells. |
| 264 | 1 | b Elsevier BV,c 2009 |
| 520 | a Steady-state dendritic cells (DCs) migrating in the lymph from the intestine induce tolerance to harmless intestinal antigens, preventing inflammatory responses. To determine if such DCs are inherently tolerogenic we collected intestinal lymph DCs (L-DCs) by cannulation of the thoracic duct of rats after mesenteric lymphadenectomy, and examined their capacity to activate naive CD4+ lymphocytes in an allogeneic mixed leucocyte reaction. L-DCs stimulated strong proliferative responses, induced secretion of inflammatory cytokines including interferon-gamma, and induced FoxP3-positive lymphocytes to divide. To determine if the activated CD4+ T cells had been tolerized, they were rested and restimulated with irradiated splenocytes. The restimulated CD4+ T cells again proliferated and secreted inflammatory cytokines. These data demonstrate that the DCs, which migrate from the intestine in the steady state, are paradoxically able to induce strong inflammatory responses from naive T cells, despite their role in the maintenance of oral tolerance. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 653 | a Animals | |
| 653 | a CD4-Positive T-Lymphocytes | |
| 653 | a immunology | |
| 653 | a Cell Movement | |
| 653 | a physiology | |
| 653 | a Cell Proliferation | |
| 653 | a Cells | |
| 653 | a Cultured | |
| 653 | a Cytokines | |
| 653 | a secretion | |
| 653 | a Dendritic Cells | |
| 653 | a immunology | |
| 653 | a physiology | |
| 653 | a Inflammation | |
| 653 | a immunology | |
| 653 | a Interferon-gamma | |
| 653 | a immunology | |
| 653 | a Lymph | |
| 653 | a immunology | |
| 653 | a Lymph Node Excision | |
| 653 | a methods | |
| 653 | a Lymphocyte Activation | |
| 653 | a immunology | |
| 653 | a Lymphocyte Culture Test | |
| 653 | a Mixed | |
| 653 | a methods | |
| 653 | a Lymphocytes | |
| 653 | a immunology | |
| 653 | a Male | |
| 653 | a Mesentery | |
| 653 | a immunology | |
| 653 | a surgery | |
| 653 | a Rats | |
| 653 | a Th1 Cells | |
| 653 | a immunology | |
| 700 | 1 | a Jenkins, C D4 aut |
| 700 | 1 | a Yrlid, Ulf,d 1971u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xyrlul |
| 700 | 1 | a Cerovic, V4 aut |
| 700 | 1 | a Edmond, H4 aut |
| 700 | 1 | a McDonald, V4 aut |
| 700 | 1 | a Nassar, M4 aut |
| 700 | 1 | a Macpherson, G4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi4 org |
| 773 | 0 | t Mucosal immunologyd : Elsevier BVg 2:2, s. 156-65q 2:2<156-65x 1935-3456x 1933-0219 |
| 856 | 4 | u https://www.nature.com/articles/mi200871.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/104287 |
| 856 | 4 8 | u https://doi.org/10.1038/mi.2008.71 |
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